本文選題：胃癌 + CT　； 參考：《廣西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:通過CT測(cè)量的腹部脂肪指標(biāo),以及BMI,以及年齡、性別、腫瘤直徑、分期、分級(jí)等指標(biāo)對(duì)胃癌根治術(shù)后總生存時(shí)間的影響,以探討各種因素在胃癌術(shù)后生存率的主要影響作用。材料和方法:搜集2011年9月至2015年12月在廣西醫(yī)科大學(xué)第一附屬醫(yī)院因胃癌住院患者,并經(jīng)胃大部切除術(shù)手術(shù)治療病理證實(shí)為胃癌患者62例。術(shù)前資料采集包括患者的性別、年齡、BMI、腫瘤直徑、腫瘤分期及分級(jí),以及術(shù)前術(shù)后6個(gè)月CT腹部脂肪測(cè)量參數(shù),包括TAT(腹部總體脂肪)、VAT(腹部?jī)?nèi)臟脂肪)、SAT(腹部皮下脂肪)。采用生存分析統(tǒng)計(jì)方法評(píng)價(jià)CT體脂參數(shù)與其他因素對(duì)胃癌手術(shù)患者預(yù)后和生存率的影響。結(jié)果:術(shù)后隨訪,TAT、VAT和SAT值均較術(shù)前顯著下降(P0.001)。所有患者的中位生存期為337天(249-425天)。在單因素分析中,腫瘤分期、術(shù)前TAT和術(shù)前SAT與生存時(shí)間有關(guān)(P0.05),即腫瘤分期較低、術(shù)前TAT較高、術(shù)前SAT較高者,生存時(shí)間較長(zhǎng)。生存時(shí)間與其他特征如年齡、性別、腫瘤大小、腫瘤分級(jí)、BMI和VAT無(wú)顯著相關(guān)。進(jìn)一步多因素分析(Cox回歸分析)結(jié)果顯示術(shù)前SAT為影響胃癌預(yù)后的相關(guān)因素(P0.05),即獨(dú)立影響因素。結(jié)論:術(shù)前SAT可能是預(yù)測(cè)胃癌患者術(shù)后生存期的生物學(xué)指標(biāo)。術(shù)前SAT較高者,生存時(shí)間較長(zhǎng)。
[Abstract]:Objective: to evaluate the effect of abdominal fat index, BMI, age, sex, tumor diameter, stage, grade and so on on the total survival time after radical gastrectomy.To explore the main effect of various factors on survival rate after operation of gastric cancer.Materials and methods: from September 2011 to December 2015, 62 patients with gastric cancer were treated by subtotal gastrectomy in the first affiliated Hospital of Guangxi Medical University.The data collected before operation included sex, age, tumor diameter, tumor stage and grade, and abdominal fat measurement parameters of CT 6 months after operation, including TAT (abdominal visceral fat) (abdominal visceral fat) and SAT (abdominal subcutaneous fat).Survival analysis was used to evaluate the effects of CT body fat parameters and other factors on the prognosis and survival rate of patients with gastric cancer.Results: the values of VAT and SAT were significantly lower than those before operation (P 0.001).The median survival time for all patients was 337 days, 249 to 425 days.In univariate analysis, tumor staging, preoperative TAT and preoperative SAT were related to survival time (P 0.05), that is, tumor stage was lower, preoperative TAT was higher, preoperative SAT was higher, survival time was longer.There was no significant correlation between survival time and other characteristics such as age, sex, tumor size, tumor grade and VAT.The results of multivariate analysis and Cox regression analysis showed that preoperative SAT was an independent factor for the prognosis of gastric cancer.Conclusion: preoperative SAT may be a biological marker for predicting postoperative survival of patients with gastric cancer.The survival time of the patients with high preoperative SAT was longer.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R735.2

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相關(guān)期刊論文 前2條

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2 Junko Ueda;Shogo Kikuchi;Yukari Totsuka;Manami Inoue;;Comparative epidemiology of gastric cancer between Japan and China[J];World Journal of Gastroenterology;2011年39期

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本文編號(hào)：1734126