本文選題：早孕期　切入點(diǎn)：超聲　出處：《吉林大學(xué)》2017年碩士論文

【摘要】：第一部分早孕期超聲檢查胎兒神經(jīng)系統(tǒng)重要參數(shù)研究目的:制定早孕期各孕齡(天)對應(yīng)顱內(nèi)透明層厚度(intracranial translucency,IT)的正常值范圍,研究IT值與孕齡(天)、頭臀徑(Crown-Rump Length,CRL)、孕婦年齡及頸項(xiàng)透明層厚度(nuchal translucency,NT)的相關(guān)性及IT值用于篩查神經(jīng)系統(tǒng)畸形的臨床意義。資料與方法:選取2013年10月至2014年12月到吉林大學(xué)第二醫(yī)院門診產(chǎn)前診斷中心就診的385例孕婦,孕婦年齡22~42歲,平均年齡(30.76±3.89)歲,胎兒孕齡11~14孕周。排除孕期檢查發(fā)現(xiàn)或可疑的解剖學(xué)異常,遺傳學(xué)異常,NT增厚,出生后隨訪出現(xiàn)異常的胎兒后,共入選355例孕婦,搜集整理所有入選病例報告單并記錄IT值,采用回顧性分析法,應(yīng)用SPSS20.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:1、制定12~(+1)~14孕周各孕齡(天)對應(yīng)IT值的正常值范圍。2、IT值與孕齡(天)呈正相關(guān)(p-value0.01),隨其增加呈線性增加。3、IT值與CRL呈正相關(guān)(p-value0.01),隨其增加呈線性增加。4、IT值與孕婦年齡無相關(guān)性(p-value0.01)。5、IT值與NT值呈正相關(guān)(p-value0.01)。結(jié)論:本研究制定了早孕期各孕齡(天)對應(yīng)IT值的正常值范圍,發(fā)現(xiàn)IT值隨孕齡(天)、CRL、NT值的增加而增加,并探討IT值用于篩查神經(jīng)系統(tǒng)異常的臨床意義。第二部分早孕期超聲檢查胎兒心血管系統(tǒng)重要參數(shù)研究目的:制定早孕期各孕齡(天)對應(yīng)頸項(xiàng)透明層厚度、心軸、心率的正常值范圍,分別研究NT值、心軸、心率與孕齡(天)、CRL、孕婦年齡的相關(guān)性,并研究NT值、心軸、心率、心內(nèi)強(qiáng)回聲、靜脈導(dǎo)管血流頻譜、三尖瓣血流用于篩查心血管系統(tǒng)異常的臨床意義。資料與方法:選取2013年10月至2014年12月到吉林大學(xué)第二醫(yī)院門診產(chǎn)前診斷中心就診的385例孕婦,孕婦年齡22~42歲,平均年齡(30.76±3.89)歲,胎兒孕齡11~14孕周。按排除標(biāo)準(zhǔn)排除后,共入選355例孕婦,搜集整理所有入選病例報告單并記錄相關(guān)數(shù)據(jù),采用回顧性分析法,應(yīng)用SPSS20.0統(tǒng)計(jì)軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果:1、制定12~(+1)~14孕周各孕齡(天)對應(yīng)NT值、心軸、心率的正常值范圍。2、NT值與孕齡(天)呈正相關(guān)(p-value0.01),隨其增加呈線性增加;與CRL呈正相關(guān),隨其增加呈線性增加(p-value0.01);與孕婦年齡無相關(guān)性(p-value0.01)。3、心軸與孕齡(天)無相關(guān)性(p-value0.01);與CRL無相關(guān)性(p-value0.01);與孕婦年齡無相關(guān)性(p-value0.01)。4、心率與孕齡(天)呈負(fù)相關(guān)(p-value0.01),隨其增加逐漸減小;與CRL呈負(fù)相關(guān),隨其增加逐漸減小(p-value0.01);與孕婦年齡無相關(guān)性(p-value0.01)。結(jié)論:本研究制定了早孕期各孕齡(天)對應(yīng)NT值、心軸、心率的正常值范圍,發(fā)現(xiàn)三者與孕齡(天)、CRL、孕婦年齡的相關(guān)性,并闡述了NT值、心軸、心率、心內(nèi)強(qiáng)回聲、靜脈導(dǎo)管血流頻譜、三尖瓣血流篩查心血管系統(tǒng)異常的臨床意義,有助于先天性心臟病早期發(fā)現(xiàn),規(guī)范監(jiān)護(hù),盡早處理,以減少缺陷兒出生提高人口素質(zhì)。
[Abstract]:Part I study on the important parameters of fetal nervous system in early pregnancy objective: to determine the normal range of the thickness of the transparent layer of the brain corresponding to the thickness of the translucent layer of the brain in each gestational age (day) during the early pregnancy. To study the correlation between IT value and gestational age (Crown-Rump Lengthia, age of pregnant women and thickness of transparent layer of neck) and the clinical significance of IT value in screening nervous system malformations. Data and methods: from October 2013 to December 2014, the clinical significance of IT value in screening nervous system malformations was studied. 385 pregnant women in the outpatient antenatal diagnosis center of the second Hospital of Jilin University, The pregnant women were 22 ~ 42 years old with an average age of 30.76 鹵3.89 years, and the gestational age of the fetus was 11 ~ 14 weeks. All the selected report forms were collected and the IT values were recorded. SPSS20.0 statistical software was used to carry out statistical analysis. Results: 1: 1, the normal range of IT value corresponding to each gestational age (day) of 14 weeks of gestation was determined. 2IT value was positively correlated with gestational age (day). With the increase of IT value, there was a positive correlation between IT value and CRL. There was no correlation between the value of IT and the age of pregnant women. There was a positive correlation between the value of IT and the value of NT. Conclusion: this study established the normal range of IT values for each gestational age (day) in early pregnancy. It was found that the IT value increased with the increase of gestational age (CRLN NT value). To explore the clinical significance of IT value in screening nervous system abnormalities. Part two important parameters of fetal cardiovascular system in early pregnancy objective: to determine the thickness of cervical clear layer and cardiac axis in different gestational ages during early pregnancy. The normal range of heart rate, NT value, cardiac axis, heart rate and gestational age (CRL) were studied, and NT value, cardiac axis, heart rate, intracardiac strong echo, venous blood flow spectrum were studied. Clinical significance of tricuspid blood flow in screening cardiovascular abnormalities data and methods: 385 pregnant women, aged 2242 years, were selected from October 2013 to December 2014 in the outpatient prenatal diagnosis center of the second Hospital of Jilin University. The average age was 30.76 鹵3.89 years, and the gestational age of the fetus was 1114 weeks. According to the exclusion criteria, 355 pregnant women were selected to collect all the selected case reports and record the relevant data. SPSS20.0 statistical software was used to carry out statistical analysis. Results at 1: 1, the corresponding NT values for each gestational age (day) of 14 weeks of gestation were determined. The normal value range of heart axis and heart rate was positively correlated with gestational age (day), and the value of value increased linearly with the increase of gestational age (day), and positively correlated with CRL. There was no correlation between p-value0.01n and gestational age (day), and there was no correlation between cardiac axis and gestational age (day). There was no correlation between p-value0.01g and CRL, and there was no correlation between p-value0.01n and gestational age (day). The heart rate was negatively correlated with gestational age (day), and decreased gradually with the increase of gestational age (day). There was a negative correlation with CRL, which decreased gradually with the increase of CRL, and had no correlation with the age of pregnant women. Conclusion: the normal range of NT value, cardiac axis and heart rate for each gestational age (day) in early pregnancy period was established in this study. The clinical significance of NT value, cardiac axis, heart rate, intracardiac strong echo, venous catheter blood flow spectrum and tricuspid blood flow screening for abnormal cardiovascular system were discussed. It is helpful for early detection of congenital heart disease, standardized monitoring, early treatment, in order to reduce birth defects and improve the quality of the population.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R714.5;R445.1

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