本文選題：乳腺癌　切入點(diǎn)：化療　出處：《廣州中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過(guò)調(diào)查經(jīng)廣東省中醫(yī)院病理診斷為乳腺癌并接受第1周期EC、TEC、FEC及TC化療方案后出現(xiàn)消化道反應(yīng)的患者的一般情況,觀察其消化道反應(yīng)的相關(guān)癥狀及舌脈象,進(jìn)行六經(jīng)辨證,探討乳腺癌化療所致消化道反應(yīng)的一般年齡分布情況及六經(jīng)辨證分型規(guī)律,為進(jìn)一步通過(guò)中醫(yī)藥來(lái)改善圍化療期患者的消化道反應(yīng),及化療后消化道反應(yīng)的治療思路提供一定的臨床依據(jù)。方法:本研究選擇廣東省中醫(yī)院乳腺科2016年9月至2017年1月的接受初次化療后出現(xiàn)消化道反應(yīng)的121例乳腺癌患者進(jìn)行研究,全部為女性,按照嚴(yán)格的納排標(biāo)準(zhǔn)挑選其中符合消化道反應(yīng)診斷標(biāo)準(zhǔn)并可獲取完整相關(guān)信息的100例患者,使用一般資料收集表和癥狀觀察收集表進(jìn)行相關(guān)資料收集,包括通過(guò)調(diào)查收集患者的一般情況及四診收集消化道反應(yīng)的相關(guān)癥狀和舌象脈象等,統(tǒng)一由專家根據(jù)六經(jīng)辨證進(jìn)行辨證分型,將數(shù)據(jù)匯總,用Excle錄入,用頻數(shù)分析法和計(jì)數(shù)資料卡方檢驗(yàn)進(jìn)一步分析和對(duì)比。結(jié)果:1.乳腺癌患者出現(xiàn)消化道反應(yīng)的年齡多處于40-60歲之間。2.乳腺癌消化道反應(yīng)的六經(jīng)辯證具有特定的規(guī)律。在3種不同類型的消化道反應(yīng)中,六經(jīng)辨證分型規(guī)律大體基本一致。太陰病為主要證型,依次為少陰病、厥陰病、少陽(yáng)病、陽(yáng)明病、其他病。3.在化療方案與消化道反應(yīng)關(guān)系方面,惡心嘔吐與EC方案關(guān)系最為密切,其次是FEC、TC、TEC方案;腹瀉患者中則FEC方案患者則占大多數(shù),其余由多到少依次為TC,TEC,EC;便秘則與TEC方案關(guān)聯(lián)緊密,剩余則依次為TC,EC,FEC。結(jié)論:1.本研究中,乳腺癌患者消化道反應(yīng)的發(fā)病年齡與中國(guó)乳腺癌患病年齡分布特點(diǎn)一致,并與主要證型太陰病無(wú)明顯的相關(guān)性。2.六經(jīng)辨證分型多以陰證為主,其中以太陰病和少陰病占大多數(shù),其中太陰病為主要證型。3.在乳腺癌化療方案中,EC、FEC、TEC三種方案分別與消化道反應(yīng)中的惡心嘔吐、腹瀉和便秘關(guān)系緊密。
[Abstract]:Objective: to investigate the general situation of patients with digestive tract reaction after the first cycle chemotherapy regimen ECTECTECFEC and TC, and to observe the symptoms and tongue pulse of digestive tract reaction in Guangdong Provincial Hospital of traditional Chinese Medicine (TCM). To discuss the general age distribution of digestive tract reaction induced by chemotherapy of breast cancer and the pattern of syndrome differentiation of six meridians, in order to further improve the digestive tract reaction of patients with perichemotherapy by Chinese medicine. Methods: 121 cases of digestive tract reaction after first chemotherapy from September 2016 to January 2017 were selected from mammary gland department of Guangdong traditional Chinese medicine hospital. Cancer patients were studied, 100 patients who met the diagnostic criteria of digestive tract reaction and were able to obtain complete relevant information were selected according to strict nano row criteria. The data were collected using general data collection table and symptom observation collection table. Including collecting the general situation of the patients through investigation and collecting the symptoms and tongue signs and pulses of the digestive tract reaction at the fourth diagnosis, and unifying the experts according to the syndrome differentiation of the six meridians to classify the symptoms and signs, collect the data and input them with Excle. The frequency analysis and counting data chi-square test were used to further analyze and compare. Results: 1. The age of digestive tract reaction in breast cancer patients was between 40 and 60 years old. 2. The six meridians dialectical of digestive tract reaction of breast cancer has a special law. In three different types of digestive tract reactions, The main syndromes were Taiyin disease, followed by Shaoyin disease, Jueyin disease, Shaoyang disease, Yangming disease, and other diseases. 3. In terms of the relationship between chemotherapy regimen and digestive tract reaction, Nausea and vomiting were the most closely related to the EC regimen, followed by the FEC regimen, the majority of the patients with diarrhea, and the rest from more to less. Constipation was closely associated with the TEC regimen, and the rest was TCEC-TEC-FEC.Conclusion in this study, The age of onset of digestive tract reaction in breast cancer patients was consistent with the age distribution of breast cancer in China, and there was no obvious correlation with the main syndromes of Taiyin disease. Among them, Taiyin disease is the main syndrome type. In the chemotherapy regimen of breast cancer, the three regimens of EC-FEC-TEC are closely related to nausea and vomiting, diarrhea and constipation in digestive tract reaction, respectively.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R737.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 管確;;改變飲食結(jié)構(gòu)與口服力洛治療慢性便秘68例觀察[J];基層醫(yī)學(xué)論壇;2016年S1期

2 王院春;王希勝;李仁廷;惠建榮;;經(jīng)方辨治腫瘤相關(guān)性便秘的臨床觀察[J];黑龍江中醫(yī)藥;2016年01期

3 ;我國(guó)乳腺癌發(fā)病年齡前移[J];中國(guó)腫瘤臨床與康復(fù);2015年10期

4 劉慧龍;;阿片類藥物相關(guān)不良反應(yīng)便秘的治療進(jìn)展[J];中國(guó)新藥雜志;2015年18期

5 令狐銳霞;司文;李瑩;楊俊蘭;;3846例乳腺癌流行病學(xué)及臨床病理學(xué)分析[J];解放軍醫(yī)學(xué)院學(xué)報(bào);2015年10期

6 羅群英;甘煒堅(jiān);杜斌盛;余靖華;劉泳珊;;3種化療方案治療乳腺癌的藥物經(jīng)濟(jì)學(xué)分析[J];中國(guó)執(zhí)業(yè)藥師;2015年04期

7 李凱平;;論《傷寒雜病論》的六經(jīng)辨證與臟腑辨證(上)[J];光明中醫(yī);2014年12期

8 盛樹海;鄭進(jìn);劉廣寅;李宗濤;潘薈丞;佟易凡;王欣婷;趙魁;;多西紫杉醇和表阿霉素及環(huán)磷酰胺聯(lián)合化療與序貫化療近期不良反應(yīng)的比較[J];廣東醫(yī)學(xué);2013年11期

9 陳美云;許尤琪;;溫中健脾湯治療化療相關(guān)性腹瀉40例[J];江蘇中醫(yī)藥;2013年01期

10 王樹華;;開塞露聯(lián)合濃氯化鈉灌腸在腫瘤便秘患者中的應(yīng)用[J];中國(guó)臨床研究;2012年10期

相關(guān)會(huì)議論文 前1條

1 徐飚;;林毅教授治療乳癌化療后嘔吐經(jīng)驗(yàn)介紹[A];第十一屆全國(guó)中醫(yī)及中西醫(yī)結(jié)合乳腺病學(xué)術(shù)會(huì)議論文集[C];2009年

，

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