發(fā)布時(shí)間：2018-03-17 11:04

  本文選題：性激素結(jié)合球蛋白　切入點(diǎn)：睪酮　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討新疆維吾爾族中老年男性性激素結(jié)合球蛋白(SHBG)水平變化及與其影響因素的相關(guān)性。為臨床運(yùn)用中監(jiān)測血清SHBG提供更多的指導(dǎo)意義。方法:采用整群隨機(jī)抽樣的方法,選擇新疆維吾爾自治區(qū)烏魯木齊市天山區(qū)二道橋片區(qū)及新疆托克遜縣3鎮(zhèn)4鄉(xiāng)居民進(jìn)行橫斷面調(diào)查,收錄了2015年9月-12月共620例45歲以上維吾爾族男性的基本資料包括:身高、體重、腰圍、血壓,實(shí)驗(yàn)室檢查結(jié)果包括:性激素結(jié)合球蛋白(SHBG)、睪酮(TT)、空腹血糖(FBG)、OGTT2h血糖(PBG)、糖化血紅蛋白(HbAlC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、甘油三酯(TG)、膽固醇(TC)、血尿酸(UA)、空腹胰島素(Ins)、維生素D(VitD)、骨鈣素(OST)。并通過公式計(jì)算體重指數(shù)(BMI)、胰島素抵抗指數(shù)(HOMA-IR)。按照血清SHBG水平分為低水平及正常水平分兩組,比較兩組之間上述指標(biāo)水平,并探討SHBG與上述指標(biāo)之間的關(guān)系。結(jié)果:維吾爾族中老年男性低水平性激素結(jié)合球蛋白組的TT、Ins、HOMA-IR、LDL-C水平均高于性激素結(jié)合球蛋白正常組,而年齡、收縮壓、VitD水平則低于SHBG正常組,P均小于0.05。應(yīng)用Spearman秩相關(guān)作相關(guān)分析,維吾爾族中老年男性年齡、收縮壓、舒張壓、BMI、HDL-C、VitD、OST均與SHBG呈正相關(guān)(r=0.347,r=0.158,r=0.125,r=0.097,r=0.102,r=0.439,r=0.116);FBG、TG、LDL-C、TT、Ins、HOMA-IR均與SHBG呈負(fù)相關(guān)(r=0.167,r=0.088,r=-0.424,r=-0.168,r=-0.725,r=-0.718),P均小于0.05。回歸分析提示低SHBG水平保護(hù)因素為年齡、HDL-C、VitD,而FBG、LDL-C、HOMA-IR、Ins、TT則為其危險(xiǎn)因素。結(jié)論:對(duì)于維吾爾族中老年男性來說,年齡、HDL-C、VitD可能為低水平SHBG的獨(dú)立保護(hù)因素。
[Abstract]:Objective: To investigate the Xinjiang Uygur elderly male sex hormone binding globulin (SHBG) levels and its influence factor relevance. In order to provide more guidance for monitoring serum SHBG clinical application. Methods: using cluster random sampling method, a cross-sectional survey was conducted 4 rural residents choose the Xinjiang Uygur Autonomous Region Erdaoqiao Urumqi Tianshan District area and Xinjiang Toksun County town 3, included the basic data of -12 months of September 2015 a total of 620 patients over the age of 45 Uighur men include: height, weight, waist circumference, blood pressure, laboratory examination results including: sex hormone binding globulin (SHBG), testosterone (TT), fasting blood glucose (FBG), OGTT2h blood glucose, glycosylated hemoglobin (PBG) (HbAlC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG), cholesterol (TC), blood uric acid (UA), fasting insulin (Ins), vitamin D (VitD) Osteocalcin (OST), and body mass index calculated by the formula (BMI), insulin resistance index (HOMA-IR). According to the serum SHBG levels were divided into low level and normal level is divided into two groups, the comparison between the two groups of the above indexes, and to explore the relationship between SHBG and the above indexes. Results: the globulin group TT. The low level of elderly male sex hormone binding in Uygur Ins, HOMA-IR, LDL-C were higher than the level of sex hormone binding globulin in normal group, while age, systolic blood pressure, the level of VitD was lower than SHBG normal group, P were less than 0.05. using Spearman rank correlation correlation analysis in Uygur elderly male age, systolic blood pressure, diastolic blood pressure. BMI, HDL-C, VitD, OST were positively correlated with SHBG (r=0.347, r=0.158, r=0.125, r=0.097, r=0.102, r=0.439, r=0.116); FBG, TG, LDL-C, TT, Ins, HOMA-IR were negatively correlated with SHBG (r= 0.167, r=0.088, r=-0.424, r=-0.168, r=-0.725, r=-0.718, P) were less than 0.05. Regression analysis showed that low level of SHBG protection factors were age, HDL-C, VitD, FBG, LDL-C, HOMA-IR, Ins, TT were risk factors. Conclusion: the Uygur elderly men, age, HDL-C, VitD may be the independent protective factors for the low level of SHBG.

【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R446.1

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