本文關(guān)鍵詞：新診斷2型糖尿病患者不同HbA1c水平胰島α及β細(xì)胞功能評(píng)價(jià)　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

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【摘要】：目的:了解新診斷2型糖尿病(T2DM)患者不同糖化血紅蛋白(Hb A1c)水平胰島α、β細(xì)胞功能狀況。方法:采用臨床回顧性分析的方法,選取新診斷T2DM患者269例,根據(jù)HbA1c水平將新診斷T2DM患者分為A、B、C、D組,進(jìn)行口服葡萄糖耐量試驗(yàn)(OGTT)、胰島素釋放、胰高血糖素釋放試驗(yàn),比較各組穩(wěn)態(tài)模型評(píng)估的胰島素抵抗指數(shù)(HOMA-IR)、胰島β細(xì)胞功能指數(shù)(HOMA-β)、早時(shí)相胰島素分泌指數(shù)(△I30/△G30)、第二時(shí)相胰島素分泌指數(shù)[胰島素曲線下面積(AUC_(Ins))]、胰高血糖素、胰高血糖素/胰島素、胰高血糖素曲線下面積(AUCglu)等指標(biāo),分析Hb A1c與胰島α及β細(xì)胞功能的關(guān)系,評(píng)估各組胰島α及β細(xì)胞功能。結(jié)果:(1)HbA1c與胰島β細(xì)胞的分泌及抵抗有良好的相關(guān)性(均p0.05),和胰島α細(xì)胞無(wú)明顯相關(guān)性(p0.05)。(2)隨著HbA1c水平的升高,HOMA-β、△I30/△G30、AUC_(Ins)均明顯降低(均p0.05),HOMA-IR有明顯差異(p0.05),但未見明顯趨勢(shì)。隨著HbA1c水平的升高,胰島α細(xì)胞分泌的胰升糖素絕對(duì)值無(wú)明顯差異(p0.05),但胰升糖素/胰島素比值明顯增高,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。結(jié)論:新診斷2型糖尿病患者HbA1c與胰島β細(xì)胞的分泌及抵抗有良好的相關(guān)性,和胰島α細(xì)胞無(wú)明顯相關(guān)性。隨著Hb A1c水平的升高,新診斷2型糖尿病患者胰島β細(xì)胞分泌功能逐漸減弱,胰島素各時(shí)相分泌減少,胰升糖素絕對(duì)值雖無(wú)明顯變化,但胰升糖素/胰島素比值逐漸增大,兩者比例失調(diào)加劇了2型糖尿病患者血糖的升高。
[Abstract]:Objective: to investigate the function of islet 偽 and 尾 cells in patients with newly diagnosed type 2 diabetes mellitus (T2DM) at different levels of HbA1c. methods: clinical analysis was performed retrospectively. Two hundred and sixty-nine newly diagnosed T2DM patients were divided into two groups according to HbA1c level. Oral glucose tolerance test (OGTT) and insulin release were performed. Glucagon release test was performed to compare the insulin resistance index (HOMA-IRI) and islet 尾 cell function index (HOMA- 尾). Early phase insulin secretion index (I 30 / G 30), second phase insulin secretion index (I 30 / G 30). [Area under insulin curve (AUC), glucagon, glucagon / insulin, and area under glucagon curve were measured. The relationship between HbA1c and islet 偽 and 尾 cell function was analyzed. Results there was a good correlation between HbA1c and the secretion and resistance of islet 尾 cells (all p0.05). There was no significant correlation between Homa 尾, I 30 / G30 with the increase of HbA1c level. There was a significant difference in HOMA-IR between the two groups, but there was no obvious trend. With the increase of HbA1c level, there was no obvious trend. There was no significant difference in the absolute value of glucagon secreted by islet 偽 cells, but the ratio of glucagon to insulin was significantly increased. Conclusion: there is a good correlation between HbA1c and the secretion and resistance of islet 尾 cells in newly diagnosed type 2 diabetic patients. With the increase of HbA1c level, the 尾 -cell secretory function of the newly diagnosed type 2 diabetes mellitus gradually decreased, and the secretion of insulin decreased at different time stages. Although the absolute value of glucagon did not change obviously, the ratio of glucagon to insulin gradually increased. The imbalance of the ratio of glucagon and insulin aggravated the increase of blood glucose in patients with type 2 diabetes mellitus.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R587.1

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