本文關(guān)鍵詞：滋陰補(bǔ)陽方治療腎虛型RIF的臨床研究　出處：《南京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 滋陰補(bǔ)陽方 反復(fù)種植失敗 凍胚移植 臨床研究

【摘要】：目的:觀察滋陰補(bǔ)陽方治療腎虛型反復(fù)種植失敗的臨床療效,探討滋陰補(bǔ)陽中藥是否改善腎虛型RIF患者的臨床結(jié)局及其可能的作用機(jī)理,為中西醫(yī)結(jié)合治療該病提供新的思路和方法。方法:將54例研究對(duì)象隨機(jī)分為治療組和對(duì)照組,對(duì)照組服用多維元素片每日1片,連用3個(gè)月經(jīng)周期后進(jìn)入移植周期,移植周期不停藥。治療組在對(duì)照組的基礎(chǔ)上,加用滋陰補(bǔ)陽方序貫調(diào)治3個(gè)周期,移植周期亦不停藥。比較兩組中醫(yī)證候、內(nèi)分泌激素、子宮內(nèi)膜容受性、胚胎著床率和臨床妊娠率等,評(píng)估滋陰補(bǔ)陽方治療腎虛型RIF的總體療效。結(jié)果:①治療組治療后腎虛、月經(jīng)癥狀積分均比治療前低,有顯著差異(P0.01);組間對(duì)比,治療組治療后總積分顯著低于對(duì)照組(P0.01)。②治療組患者治療后FSH較治療前降低,差異有統(tǒng)計(jì)學(xué)意義(P0.01),治療前后E2、LH、AMH無明顯差異(P0.05);組間比較,兩組患者治療后只有FSH比較有顯著差別(P0.01)。③治療組患者子宮內(nèi)膜厚度、體積、A型子宮內(nèi)膜數(shù)、PI、RI、VI治療后均較治療前改善,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。組間比較:治療組患者治療后內(nèi)膜的厚度、體積、A型子宮內(nèi)膜比例、VI均高于對(duì)照組,PI低于對(duì)照組,有明顯差異(P0.05);治療組RI治療后有下降趨勢(shì),但與對(duì)照組相比,無明顯差別(P0.05)。④治療組治療后9例妊娠,2例生化妊娠,臨床妊娠率36%,胚胎著床率26%,總有效率92%;對(duì)照組4例妊娠,3例生化妊娠,臨床妊娠率15.38%,胚胎著床率9.62%,總有效率為38.46%。結(jié)論:滋陰補(bǔ)陽方能改善腎虛型RIF患者的腎虛證候、月經(jīng)癥狀、子宮內(nèi)膜容受性,降低FSH水平,提高胚胎著床率,并有望進(jìn)一步提高臨床妊娠率。
[Abstract]:Objective: to observe the clinical effect of nourishing yin and tonifying yang prescription in the treatment of repeated implantation failure of kidney deficiency type, and to explore whether the traditional Chinese medicine for nourishing yin and reinforcing yang can improve the clinical outcome and possible action mechanism of RIF patients with kidney deficiency type. Methods: 54 patients were randomly divided into treatment group and control group. Treatment group on the basis of the control group, the treatment group with yin tonifying Yang prescription sequential treatment of 3 cycles, the transplantation cycle is also non-stop drugs. Compare the two groups of TCM syndrome. Endocrine hormone, endometrial receptivity, embryo implantation rate and clinical pregnancy rate were evaluated to evaluate the overall efficacy of Ziyin Buyang recipe in the treatment of kidney deficiency type RIF. The scores of menstrual symptoms were significantly lower than those before treatment (P 0.01). The total score of the treatment group was significantly lower than that of the control group after treatment, the FSH of the treatment group was significantly lower than that of the pre-treatment group, the difference was statistically significant (P 0.01). There was no significant difference in AMH between before and after treatment (P 0.05). There was significant difference in endometrial thickness and volume of type A endometrium between the two groups after treatment with FSH. VI was improved after treatment, the difference was statistically significant (P 0.05). Comparison between groups: the thickness of endometrium and volume of type A endometrium in the treatment group were higher than those in the control group. Pi was lower than that of control group (P 0.05). The RI of the treatment group decreased after treatment, but there was no significant difference between the treatment group and the control group (P 0.054.The clinical pregnancy rate was 36%). The embryo implantation rate was 26% and the total effective rate was 92%. The clinical pregnancy rate was 15.38 and the embryo implantation rate was 9.62%. The total effective rate was 38.46.Conclusion: the prescription of nourishing yin and tonifying yang can improve the syndrome of kidney deficiency, menstrual symptoms, endometrial receptivity, decrease the level of FSH and increase the rate of embryo implantation in RIF patients with kidney deficiency. It is expected to further improve the clinical pregnancy rate.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R271.9

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