發(fā)布時(shí)間：2018-01-08 04:17

  本文關(guān)鍵詞：加味二妙顆粒聯(lián)合尤靖安治療HR-HPV持續(xù)感染伴CINI臨床觀察　出處：《南京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 人乳頭瘤病毒 低級(jí)別宮頸上皮內(nèi)瘤變 中西醫(yī)結(jié)合療法 加味二妙顆粒

【摘要】：目的:觀察加味二妙顆粒聯(lián)合尤靖安治療HR-HPV持續(xù)感染伴CINI臨床療效,尋求一種可以有效預(yù)防宮頸癌的中藥組方。方法:選取2014年10月至2016年03月期間,就診于江蘇省中醫(yī)院婦科門診的60例患者,根據(jù)納入標(biāo)準(zhǔn),將60例HR-HPV持續(xù)感染伴CINI的患者隨機(jī)分為中藥聯(lián)合干擾素治療組、干擾素對(duì)照組,每組30例。治療組采用加味二妙顆粒聯(lián)合尤靖安治療,對(duì)照組僅予尤靖安。以3個(gè)月為一個(gè)療程,兩組均治療2個(gè)療程,觀察HPV轉(zhuǎn)陰率、CINI逆轉(zhuǎn)率、中醫(yī)證候積分變化及臨床療效情況。結(jié)果:①中藥聯(lián)合干擾素治療組患者HPV轉(zhuǎn)陰26例,干擾素組患者HPV轉(zhuǎn)陰19例,兩組HPV轉(zhuǎn)陰率比較有顯著的統(tǒng)計(jì)學(xué)差異,聯(lián)合治療組的HPV轉(zhuǎn)陰率明顯高于對(duì)照組。②中藥聯(lián)合干擾素治療組CINI逆轉(zhuǎn)27例,干擾素對(duì)照組CINI逆轉(zhuǎn)20例,中藥聯(lián)合干擾素治療組CINI的逆轉(zhuǎn)率明顯高于干擾素對(duì)照組。③按中醫(yī)證候積分比較:兩組治療前后積分均明顯減少,治療后組間比較,中藥聯(lián)合干擾素治療組明顯優(yōu)于干擾素對(duì)照組。④中藥聯(lián)合干擾素治療組、干擾素對(duì)照組總有效率為93.33%、73.33%,中藥聯(lián)合干擾素治療組在臨床療效方面明顯優(yōu)于干擾素對(duì)照組。結(jié)論:加味二妙顆粒聯(lián)合尤靖安對(duì)于治療濕熱下注型HR-HPV持續(xù)感染伴CINI的患者有較好臨床療效,在提高HPV轉(zhuǎn)陰率、逆轉(zhuǎn)宮頸病理改變及改善患者的中醫(yī)證候方面較單用西藥作用更為明顯,且用藥安全、可靠,無(wú)毒副作用,值得臨床進(jìn)一步推廣。
[Abstract]:Objective: to observe the clinical effect of Jiawei Ermiao granule combined with Youjing'an in the treatment of HR-HPV persistent infection with CINI. Methods: from October 2014 to March 2016, 60 patients were selected from gynecological outpatient department of Jiangsu Provincial traditional Chinese Medicine Hospital. According to the inclusion criteria, 60 patients with HR-HPV persistent infection with CINI were randomly divided into two groups: Chinese medicine combined with interferon group and interferon control group. There were 30 cases in each group. The treatment group was treated with Jiawei Ermiao granule combined with you Jingan, while the control group was treated with you Jingan only. Results 26 cases of HPV and 19 cases of HPV of interferon group were treated with Chinese herbal medicine combined with interferon in the treatment group. Results: the reverse rate of CINI, the integral change of TCM syndromes and the clinical curative effect were 26 cases in the treatment group and 19 cases in the interferon group. The negative rate of HPV in the combined treatment group was significantly higher than that in the control group. 2. 27 cases of CINI were reversed in combination with interferon group. The reverse rate of CINI in the interferon control group was significantly higher than that in the interferon control group according to TCM syndrome score: the scores of both groups were significantly decreased before and after treatment. After treatment, the Chinese medicine combined with interferon treatment group was significantly better than the interferon control group. 4. The total effective rate of interferon control group was 93.33 ~ 73.33%. The therapeutic effect of Chinese herbal medicine combined with interferon group is obviously better than that of interferon control group. Conclusion:. Jiawei Ermiao granule combined with Youjing'an has a good clinical effect on the patients with HR-HPV persistent infection associated with CINI. In improving HPV negative rate, reversing cervical pathological changes and improving the TCM syndrome of patients with more obvious effect than the use of western medicine alone, and the use of safe, reliable, no toxic side effects, worthy of further clinical promotion.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R737.33

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