本文關(guān)鍵詞：胃黏膜不同萎縮范圍的血清學(xué)分析　出處：《廣西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 慢性萎縮性胃炎 胃蛋白酶原 胃泌素-17 木村-竹本

【摘要】：目的:慢性萎縮性胃炎是胃癌的主要癌前疾病,血清胃蛋白酶原(PG)和胃泌素-17(G-17)是胃體和胃竇黏膜萎縮的血清學(xué)標(biāo)志物。本研究旨在分析廣西地區(qū)慢性萎縮性胃炎中不同萎縮范圍的血清PG和G-17水平的變化,探討血清學(xué)檢測(cè)對(duì)篩查慢性萎縮性胃炎的臨床意義。方法:收集2015年12月至2016年8月在廣西壯族自治區(qū)人民醫(yī)院行上消化道內(nèi)鏡檢查符合入組標(biāo)準(zhǔn)者共125例,根據(jù)病理結(jié)果分為對(duì)照組(包括正常和非萎縮性胃炎)和萎縮性胃炎組。根據(jù)木村-竹本提出的慢性萎縮性胃炎的萎縮分型系統(tǒng),將萎縮性胃炎組細(xì)分為A組(C1)、B組(C2+C3)、C組(O1+O2+O3)和D組(O4)四個(gè)不同萎縮范圍的亞組。同時(shí)檢測(cè)血清PGI、PGII、PGI/PGII(PGR)、G-17水平,分析比較各組血清學(xué)指標(biāo)的水平變化。結(jié)果:1.對(duì)照組共56例,萎縮性胃炎組共69例(其中A組21例,B組31例,C組12例,D組5例)。2.血清PG水平:萎縮性胃炎組的PGI和PGR水平低于對(duì)照組(P0.05),且胃竇伴胃體萎縮(B+C+D組)的PGI和PGR水平明顯低于單純胃竇萎縮(A組)和對(duì)照組(P0.05)。萎縮性胃炎組中,由A到D組,PGI和PGR水平呈逐漸下降趨勢(shì),其中PGR的下降趨勢(shì)具有顯著性(P0.05)。PGII水平在萎縮性胃炎組顯著高于對(duì)照組(P0.05),在萎縮性胃炎組各亞組間無(wú)顯著差異(P0.05)。3.血清G-17水平:萎縮性胃炎組的G-17水平明顯低于對(duì)照組(P0.05)。萎縮性胃炎組中,G-17水平在各組間無(wú)顯著差異(P0.05)。結(jié)論:1.血清PGI和PGR水平(尤其是PGR)隨著胃黏膜萎縮范圍的變廣,呈一定的下降趨勢(shì)。2.聯(lián)合檢測(cè)血清PG和G-17對(duì)預(yù)測(cè)胃黏膜萎縮部位及范圍具有一定參考價(jià)值。3.動(dòng)態(tài)檢測(cè)血清PGI和PGR水平對(duì)監(jiān)測(cè)胃黏膜萎縮病變的發(fā)展可能具有一定的臨床價(jià)值。
[Abstract]:Objective: chronic atrophic gastritis is the main precancerous disease of gastric cancer. Serum pepsinogen) and gastrin-17 G-17). This study was designed to analyze the changes of serum PG and G-17 levels in different atrophy areas of chronic atrophic gastritis in Guangxi. To explore the clinical significance of serological examination in screening chronic atrophic gastritis. From December 2015 to August 2016, a total of 125 cases of upper gastrointestinal endoscopy were collected from Guangxi Zhuang Autonomous region people's Hospital. According to the pathological results were divided into control group (including normal and non-atrophic gastritis) and atrophic gastritis group. The patients with atrophic gastritis were subdivided into four subgroups with different atrophic ranges: group A, C, C, C, C, C, C, C, C, C, C, O 2, O 2, O 3, and D, and the serum PGI levels were detected at the same time. The serum levels of PGI / PGI / PGI / PGRN G-17 were analyzed and compared in each group. Results: 1.The control group consisted of 56 cases. There were 69 cases of atrophic gastritis (including 21 cases in group A, 31 cases in group B and 12 cases in group C). Serum PG level: the levels of PGI and PGR in the atrophic gastritis group were lower than those in the control group (P 0.05). The levels of PGI and PGR in the antrum with atrophy of gastric body (B C D group) were significantly lower than those in the simple antrum atrophy group (A group) and the control group (P 0.05). In the atrophic gastritis group, the levels of PGI and PGR were significantly lower than those in the group A to D. The levels of PGI and PGR decreased gradually, and the level of PGR in the atrophic gastritis group was significantly higher than that in the control group (P 0.05). There was no significant difference among the subgroups in atrophic gastritis group (P 0.05). 3. Serum G-17 level: the G-17 level in atrophic gastritis group was significantly lower than that in control group (P0.05). In atrophic gastritis. There was no significant difference in G-17 levels among the groups (P 0.05). Conclusion: 1. Serum PGI and PGR levels (especially PGRs) increased with gastric mucosal atrophy. The combined detection of serum PG and G-17 has certain reference value in predicting the location and range of gastric mucosal atrophy. 3. Dynamic detection of serum levels of PGI and PGR is useful for monitoring gastric mucosal wilting. The development of contractive lesions may have some clinical value.
【學(xué)位授予單位】：廣西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R573.32

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