發(fā)布時間：2018-01-02 10:19

  本文關(guān)鍵詞：完全腔鏡下與開放性甲狀腺癌根治術(shù)對機體應(yīng)激反應(yīng)的影響　出處：《新疆醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 腔鏡 甲狀腺癌根治術(shù) 應(yīng)激反應(yīng)

【摘要】：目的:比較完全腔鏡下甲狀腺癌根治術(shù)與開放性甲狀腺癌根治術(shù)對機體產(chǎn)生的應(yīng)激反應(yīng)的強度,間接反映兩種手術(shù)方式對機體創(chuàng)傷大小。方法:選擇新疆醫(yī)科大學(xué)附屬中醫(yī)醫(yī)院2015年6月至2016年9月間的甲狀腺癌患者94例,分為2組。腔鏡組48例行完全腔鏡下胸、乳路徑甲狀腺癌根治術(shù);另外46例患者行傳統(tǒng)開放性甲狀腺癌根治術(shù),為對照組。檢測指標(biāo)為血清白細胞介素-6和C反應(yīng)蛋白,抽血時點為術(shù)前一天、術(shù)后2小時、術(shù)后24小時、術(shù)后72小時。結(jié)果:1.術(shù)前血清IL-6、CRP水平腔鏡組和開放組相比較差異無統(tǒng)計學(xué)意義(P0.05);2.2組患者術(shù)后2小時IL-6水平升至峰值,術(shù)后24h、72hIL-6水平與術(shù)后2小時值相比,呈下降趨勢,逐漸回落,兩組間比較差異無統(tǒng)計學(xué)意義(P0.05)。3.術(shù)后各時段兩組間血清CRP水平逐漸升高,呈上升趨勢,在術(shù)后72h時達到高值,術(shù)后2小時CRP值相比較差異無統(tǒng)計學(xué)意義(P0.05);兩組術(shù)后24小時、72小時血清CRP值相比較差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論:完全腔鏡下甲狀腺癌根治術(shù)對血清應(yīng)激細胞因子影響更小,且手術(shù)切口更加隱蔽及美觀,給患者帶來的機體及心理上的創(chuàng)傷更小。
[Abstract]:Objective: to compare the intensity of stress response between radical thyroidectomy and open radical thyroidectomy. Methods: 94 patients with thyroid cancer were selected from June 2015 to September 2016 in TCM Hospital affiliated to Xinjiang Medical University. The patients in the endoscopic group were divided into 2 groups. 48 patients in the endoscopic group underwent radical resection of thyroid carcinoma with complete endoscopic approach. The other 46 patients were treated with traditional open thyroid cancer radical operation as control group. The serum levels of interleukin-6 and C-reactive protein were measured. The blood sampling time was one day before operation, 2 hours after operation and 24 hours after operation. Results at 72 hours postoperatively, there was no significant difference in serum levels of IL-6 and CRP between the endoscopic group and the open group (P 0.05). The level of IL-6 rose to the peak at 2 hours after operation, and the level of IL-6 at 24 hours and 72 hours after operation showed a downward trend and gradually decreased compared with the value of 2 hours after operation. There was no significant difference between the two groups (P0.05. 3). The serum CRP level of the two groups increased gradually and showed an upward trend at 72 hours after operation, and reached a high value at 72 hours after operation. There was no significant difference in CRP between two hours after operation (P 0.05). There was significant difference in serum CRP between the two groups at 24 hours and 72 hours postoperatively (P 0.05). Conclusion: the effect of radical resection of thyroid carcinoma under complete endoscopy on serum stress cytokines is less. The surgical incision is more subtle and beautiful, and brings less trauma to the patients.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R736.1

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