本文關(guān)鍵詞：新型可降解生物醫(yī)用Zn-Sn及Zn-Zr合金的組織及性能研究　出處：《太原理工大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 生物醫(yī)用可降解金屬材料 Zn-Sn合金 Zn-Zr合金 生物相容性

【摘要】：基于良好生物相容性和力學(xué)性能,近二十年來可降解生物醫(yī)用金屬材料成為植入材料領(lǐng)域研究的熱點。以鎂及鎂合金和鐵及鐵合金為代表進行了大量研究,但因前者降解速率過快、而后者降解速率過慢的問題制約其在臨床上的應(yīng)用。鋅及其合金是近幾年來被發(fā)現(xiàn)的一種新型生物可降解金屬材料,且比鎂耐腐蝕,比鐵易腐蝕,可避免降解過快或者過慢引發(fā)的問題。但是,純鋅力學(xué)性能較差,無法滿足植入體內(nèi)材料所要求的力學(xué)性能,這是制約其發(fā)展的重要因素。為了改善純鋅的力學(xué)性能,本課題設(shè)計并采用熱擠壓成型工藝制備了Zn-Sn和Zn-Zr兩種體系六種成分的新型生物鋅合金。表征和分析了不同Sn、Zr含量對鋅合金微觀組織結(jié)構(gòu)、物相成分、顯微硬度、拉伸性能等的影響規(guī)律;對比了兩種體系合金的降解過程和腐蝕機理,并對其生物相容性進行了評價。研究結(jié)果如下:擠壓態(tài)Zn-Sn合金的成分分別為Zn-0.9Sn、Zn-1.4Sn和Zn-1.9Sn。ZnSn合金中的Zn和Sn并沒有形成固溶體或者中間相,富錫相均勻分布于其基體中。Zn-Sn合金的拉伸強度、屈服強度和延伸率與純鋅相比均有了一定程度的改善,最大增幅分別達到21.3%、29.9%和68.6%。Zn-Sn合金的耐腐蝕性隨著Sn含量的增加而提高,Zn-1.9Sn的耐蝕性最優(yōu),降解速率僅為0.08 mm/y。Zn-Sn合金的生物相容性評價表明其雖有良好的血液相容性,但細(xì)胞相容性并不理想,會產(chǎn)生細(xì)胞毒性。擠壓態(tài)Zn-Zr合金的成分分別為Zn-0.5Zr、Zn-0.8Zr和Zn-1.1Zr。ZnZr合金中的Zn和Zr會形成中間相Zn2Zr,其主要存在于富鋯相中。Zn-Zr合金的拉伸強度、屈服強度和延伸率比純鋅分別提高了69.9%、54.6%和19.6%。Zn-Zr合金的耐蝕性會隨著Zr含量的增加而增強,Zn-1.1Zr和Zn-0.8Zr的耐蝕性相對較好。與Zn-Sn合金對比,Zn-Zr合金具有更加優(yōu)良的血液相容性和細(xì)胞相容性,細(xì)胞毒性實驗結(jié)果也表明其對細(xì)胞無毒性,甚至?xí)龠M細(xì)胞的生長增殖。綜合對比各項性能,Zn-Zr合金的性能明顯優(yōu)于Zn-Sn合金。Zn-Zr合金的力學(xué)性能、降解速率和生物相容性均符合可降解生物醫(yī)用金屬材料的要求,其中Zn-0.8Zr各項指標(biāo)優(yōu)異,是最佳的可降解生物鋅合金材料。
[Abstract]:Based on good biocompatibility and mechanical properties, biodegradable biomedical metal materials have become a hot spot in the field of implant materials in the past two decades. A large number of researches have been carried out on magnesium and magnesium alloys and iron and ferroalloys. However, the former degradation rate is too fast, while the latter degradation rate is too slow to restrict its clinical application. Zinc and its alloys are a new biodegradable metal material found in recent years, and are more resistant to corrosion than magnesium. Iron is more susceptible to corrosion and can avoid the problems caused by too fast or too slow degradation. However, the mechanical properties of pure zinc are poor and can not meet the mechanical properties required by implanted materials. In order to improve the mechanical properties of pure zinc, this is an important factor restricting its development. In this paper, a new type of zinc alloy with six components in Zn-Sn and Zn-Zr systems was designed and prepared by hot extrusion process. Different Sn was characterized and analyzed. The effect of Zr content on microstructure, phase composition, microhardness and tensile properties of zinc alloy; The degradation process and corrosion mechanism of the two alloys were compared and their biocompatibility was evaluated. The results are as follows: the composition of extruded Zn-Sn alloy is Zn-0.9Sn respectively. Zn and Sn in Zn-1.4Sn and Zn-1.9Sn.ZnSn alloys do not form solid solution or mesophase. Compared with pure zinc, the tensile strength, yield strength and elongation of the rich tin phase distributed uniformly in the matrix of. Zn-Sn alloy were improved to a certain extent, with the maximum increase of 21.3%, respectively. The corrosion resistance of 29.9% and 68.6% Zn-Sn alloy increases with the increase of Sn content, and the corrosion resistance of Zn-1.9 Sn alloy is optimized. Biocompatibility evaluation of 0.08 mm/y.Zn-Sn alloy showed that it had good blood compatibility, but its cytocompatibility was not ideal. The components of the extruded Zn-Zr alloy are Zn-0.5Zr respectively. Zn and Zr in Zn-0.8Zr and Zn-1.1Zr.ZnZr alloys form mesophase Zn2Zr.The tensile strength of Zn-Zr alloy mainly exists in Zirconium rich phase. Compared with pure zinc, the yield strength and elongation increased by 69.9% and 19.6%, respectively. The corrosion resistance of Zn-Zr alloy increased with the increase of Zr content. The corrosion resistance of Zn-1.1Zr and Zn-0.8Zr is relatively good. Compared with Zn-Sn alloy, Zn-Zr alloy has better blood compatibility and cell compatibility. Cytotoxicity test results also show that it is not toxic to cells, and even promote the growth and proliferation of cells. The mechanical properties of Zn-Zr alloy are obviously better than those of Zn-Sn alloy. Zn-Zr alloy. The degradation rate and biocompatibility of Zn-Zr alloy meet the requirements of biodegradable biomedical metal materials. Zn-0.8Zr is the best biodegradable biodegradable zinc alloy because of its excellent properties.
【學(xué)位授予單位】：太原理工大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TG146.13;R318.08

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