本文關(guān)鍵詞：基于關(guān)聯(lián)規(guī)則的焦慮抑郁共病中醫(yī)證候規(guī)律研究　出處：《北京中醫(yī)藥大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 關(guān)聯(lián)規(guī)則 焦慮抑郁共病 聚類分析 中醫(yī)證候

【摘要】：研究目的:采用數(shù)據(jù)挖掘技術(shù)中的關(guān)聯(lián)規(guī)則方法對(duì)焦慮抑郁共病的中醫(yī)證候進(jìn)行主要分析并應(yīng)用聚類分析作為輔助對(duì)結(jié)果進(jìn)行系統(tǒng)驗(yàn)證。通過探索焦慮抑郁共病中醫(yī)癥狀間的相互聯(lián)系,并分析相關(guān)主要證候要素,深入總結(jié)證候要素間的關(guān)聯(lián)關(guān)系,最終歸納焦慮抑郁共病的中醫(yī)核心病機(jī)和證候分布規(guī)律。研究方法:本課題采用橫斷面研究,在2014年10月至2016年10月期間在北京安定醫(yī)院、北京回龍觀醫(yī)院、北京中醫(yī)藥大學(xué)第三附屬醫(yī)院、連云港市中醫(yī)院等4家醫(yī)院收集焦慮抑郁共病患者。通過焦慮自評(píng)量表和抑郁自評(píng)量表對(duì)可疑患者進(jìn)行篩選,對(duì)符合焦慮抑郁共病納入條件的患者,完成中醫(yī)證候觀察表,并通過漢密爾頓焦慮量表和抑郁量表記錄患者的嚴(yán)重程度。將課題觀察表的相關(guān)資料通過Microsoft Excel 2010建立數(shù)據(jù)庫(kù),通過SPSS 21.0和數(shù)據(jù)挖掘軟件SPSS Modeler14.1對(duì)數(shù)據(jù)進(jìn)行關(guān)聯(lián)規(guī)則分析和系統(tǒng)聚類分析,在中醫(yī)理論的指導(dǎo)下,對(duì)焦慮抑郁共病的證候規(guī)律進(jìn)行研究。研究結(jié)果:(1)523例符合納入標(biāo)準(zhǔn)的焦慮抑郁共病患者中,年齡最低21歲,最高65歲,男女比例為1:1.58。其中40-60歲是本病的高發(fā)病年齡階段,約占56%。在41-50歲之間男女比例為1:1.02,說明在本年齡階段男性的患病比例明顯提高。(2)通過漢密爾頓焦慮量表和抑郁量表對(duì)疾病的嚴(yán)重程度研究,結(jié)果表明研究人群以輕度焦慮和抑郁為主,所占比例在70%-80%之間。中度焦慮抑郁和重度焦慮抑郁的比例均在10%左右;30-40歲之間,中度和重度焦慮所占比例較高,達(dá)到25%和16.7%,重度抑郁所占比例為22.6%,同樣高于平均值。提示30-40歲之間的共病患者的焦慮和抑郁程度普遍較重;不同性別患者中,焦慮和抑郁程度都以輕度為主,所占比例在80%左右,但中度和重度焦慮抑郁以男性所占比例較高。提示男性共病患者焦慮和抑郁程度更重。(3)關(guān)聯(lián)規(guī)則研究發(fā)現(xiàn)焦慮抑郁共病的常見中醫(yī)癥狀為擔(dān)憂、心煩易怒、緊張、神疲乏力、善食易饑、入睡困難、多夢(mèng)、興趣索然等。根據(jù)關(guān)聯(lián)規(guī)則和中醫(yī)理論提取出14項(xiàng)證候要素,即肝氣郁,肝火旺,心氣虛,心血虛,心陰虛,心陽(yáng)虛,心火亢盛,脾氣虛,脾陽(yáng)虛,腎陰虛,腎陽(yáng)虛,膽氣虛,痰濕和血瘀。采用關(guān)聯(lián)規(guī)則對(duì)14項(xiàng)證候要素的關(guān)系進(jìn)行分析,并用聚類分析輔助驗(yàn)證,在中醫(yī)理論的指導(dǎo)下,歸納出焦慮抑郁共病5個(gè)中醫(yī)證型,分別為:肝郁化火證、腎虛肝郁證、肝郁脾虛證、心膽氣虛證、脾腎陽(yáng)虛證。(4)對(duì)焦慮抑郁共病的5項(xiàng)證型的主癥、次癥歸納結(jié)果為:①肝郁化火證,主癥:口干口苦,脅肋脹痛,入睡困難,多夢(mèng),頭暈。次癥:面部烘熱,多疑,頭痛,耳鳴,早醒,便秘。②腎虛肝郁證,主癥:精神萎靡,脅肋脹痛,善太息,頭暈,恐懼,腰酸背痛。次癥:足膝酸軟,腹脹,胸悶氣短,畏寒肢冷。③肝郁脾虛證,主癥:神思不聚,脅肋脹痛,善嘆息,暖氣,腹瀉。次癥:畏寒肢冷,胸悶氣短,梅核氣,納差,腹脹,腹痛。④心膽氣虛證,主癥:精神萎靡,膽怯易驚,心悸,恐懼,多疑,入睡困難,悲傷欲哭。次癥:口干口苦,早醒,胸悶氣短,胸痛,自汗,畏寒肢冷。⑤脾腎陽(yáng)虛證,主癥:精神萎靡,神思不聚,恐懼,頭暈,腹瀉,腰酸背痛,足膝酸軟。次癥:納差,暖氣,腹脹,畏寒肢冷,性欲低下。研究結(jié)論:(1)本研究采用關(guān)聯(lián)規(guī)則和聚類分析等數(shù)據(jù)挖掘方法對(duì)焦慮抑郁共病的中醫(yī)證候分布規(guī)律進(jìn)行探索。歸納出5個(gè)焦慮抑郁共病的中醫(yī)證候:肝郁化火證、腎虛肝郁證、肝郁脾虛證、心膽氣虛證、脾腎陽(yáng)虛證。通過證候因子的評(píng)分,發(fā)現(xiàn)本病的病位要素與心、肝、膽關(guān)系密切,病性要素與火熱、氣虛、氣郁等關(guān)系密切。(2)本研究證實(shí)關(guān)聯(lián)規(guī)則在證候降維、降階和升階方面均具有良好的作用,能夠較準(zhǔn)確的反映疾病的證候規(guī)律特征,可以用于中醫(yī)證候研究。
[Abstract]:Objective: To study TCM syndrome using association rule mining method of comorbid anxiety and depression are mainly analyzed and application of clustering analysis as the auxiliary system to verify the results. Through the exploration of comorbid anxiety and depression related symptoms among, and the analysis of the relevant main elements of syndrome, syndrome relationship in-depth summary elements of the core, the TCM pathogenesis and syndrome distribution induced comorbid anxiety and depression. Methods: a cross-sectional study of this topic, in the period from October 2014 to October 2016 in Beijing Anding Hospital, Beijing Hui Long Guan Hospital, Third Affiliated Hospital of Beijing University of Chinese Medicine, Lianyungang Hospital of Traditional Chinese Medicine and 4 hospitals were collected. Patients with comorbid anxiety and depression by self rating Anxiety Scale and self rating Depression Scale for suspected patients were screened for with comorbid anxiety and depression conditions included patients completed Medicine syndrome observation table, and the Hamilton anxiety scale and depression scale, the severity of the patients records. The relevant information subject observation table by Microsoft Excel 2010 database, SPSS Modeler14.1 software to analyze the data association rules analysis and system clustering and data mining by SPSS 21, under the guidance of Chinese medicine theory, for study on the regularity of TCM syndrome of comorbid anxiety and depression. The results of the study: (1) 523 patients met the inclusion criteria of comorbid anxiety and depression in patients with a minimum age of 21 years old, 65 years old, male to female ratio of 1:1.58. which is a high incidence of 40-60 years old age stage of the disease, accounting for about 56%. in the proportion of men and women between the ages of 41-50 for 1:1.02, that increase in the proportion of patients in this age of men. (2) research on disease severity by Hamilton anxiety scale and depression scale, the research results show that people with mild coke Worry and depression, the proportion between 70%-80%. Moderate anxiety depression and severe anxiety and depression proportion were about 10%; age between 30-40, moderate and severe anxiety accounted for a higher proportion, reached 25% and 16.7%, severe depression accounted for 22.6%, higher than the same average. In between the ages of 30-40 co patients with anxiety and depression generally heavier; patients with different gender, anxiety and depression are mainly mild, the proportion is about 80%, but the moderate and severe anxiety and depression in men accounted for a higher proportion of male patients. It is suggested that anxiety and depression more serious. (3) the research of association rules discovery the common symptoms of comorbid anxiety and depression anxiety, irritability, tension, lassitude, bulimia, sleep difficulties, dreaminess, interest and so on. According to the association rules and the theory of traditional Chinese medicine extract 14 syndrome factors, namely liver qi depression, anger ,蹇?jī)姘旇櫍?

本文編號(hào)：1357363