本文選題：聚氨酯靜電紡絲膜 + 多壁碳納米管�。� 參考：《聊城大學(xué)》2017年碩士論文

【摘要】：敷料是用來(lái)覆蓋傷口的材料,目的是提供有利的環(huán)境使傷口愈合。眾所周知,傷口容易被各種細(xì)菌感染,從而導(dǎo)致傷口惡化、化膿等,因此,用來(lái)覆蓋傷口的敷料應(yīng)具有比較好的抗菌性,從而能夠用來(lái)防止傷口感染,但是目前所使用的大部分敷料不能滿足抗菌的要求。本論文以聚氨酯(TPU)靜電紡絲膜為基材,在TPU靜電紡絲膜上構(gòu)建了三類抗菌表面,并且研究了改性前后表面的結(jié)構(gòu)、組成以及抗菌性能。具體研究?jī)?nèi)容如下:第一:在TPU靜電紡絲膜上構(gòu)建單層殺菌表面。利用超聲分散法將多壁碳納米管(MWCNT)固定到TPU靜電紡絲膜上,制成了TPU/MWCNT靜電紡絲膜。得到的主要結(jié)論如下:(1)射線光電子能譜(XPS)、掃描電子顯微鏡(SEM)和液滴形貌分析儀(DSA)表征了TPU靜電紡絲膜改性前后的組成、形貌以及潤(rùn)濕性的變化,證明MWCNT成功的固定到TPU靜電紡絲膜上(2)SEM以及涂布平板法證明了TPU/MWCNT靜電紡絲膜具有較好單層殺菌性能。第二:在TPU靜電紡絲膜上構(gòu)建雙層殺菌表面。先將多壁碳納米管的羧基活化,再與鹽酸萬(wàn)古霉素(Van)的氨基反應(yīng),制成了Van-MWCNT粉末。然后將MWCNT、Van-MWCNT分別超聲到TPU靜電紡絲膜上,制備了TPU/MWCNT、TPU/Van-MWCNT靜電紡絲膜。得到的主要結(jié)論如下:(1)表面全反射傅里葉紅外光譜(ATR-FTIR)、XPS表征了TPU靜電紡絲膜改性前后的表面化學(xué)性質(zhì),證明Van成功接枝到MWCNT。(2)ATR-FTIR、顏色變化、SEM和DSA表征了TPU靜電紡絲膜改性前后的表面化學(xué)性質(zhì)、顏色、形貌以及潤(rùn)濕性的變化,證明Van-MWCNT成功的固定到TPU靜電紡絲膜上。(3)對(duì)金黃色葡萄球菌進(jìn)行最低抑菌濃度測(cè)試,發(fā)現(xiàn)Van-MWCNT比MWCNT的最低抑菌濃度小,證明Van-MWCNT具有較好的殺菌性能。(4)SEM以及涂布平板法證明了TPU/Van-MWCNT靜電紡絲膜具有較好的雙層殺菌性能。第三:在TPU靜電紡絲膜上構(gòu)建抗殺結(jié)合的表面。通過(guò)紫外接枝的方法使具有抗污功能的聚乙二醇(PEG)接枝到TPU靜電紡絲膜上,再利用超聲波細(xì)胞粉碎機(jī)將MWCNT超聲到TPU-g-PEG靜電紡絲膜上,得到TPU-g-PEG/MWCNT靜電紡絲膜。得到的主要結(jié)論如下:(1)X-射線光電子能譜儀(XRD)、DSA以及SEM表征了TPU靜電紡絲膜改性前后的表面化學(xué)性質(zhì)、潤(rùn)濕性和形貌的變化,證明了PEG成功的接枝到TPU靜電紡絲膜上。(2)XRD、DSA、顏色變化以及SEM表征了TPU靜電紡絲膜改性前后的表面化學(xué)性質(zhì)、潤(rùn)濕性、顏色和形貌的變化,證明了MWCNT成功的固定到TPU-g-PEG靜電紡絲膜上。(3)紅細(xì)胞粘附和溶血測(cè)試,證明了PEG具有很好的抗粘附的功能并且減少了MWCNT對(duì)紅細(xì)胞的毒性。(4)SEM以及涂布平板法證明了TPU-g-PEG/CNT靜電紡絲膜不僅具有較好的抗污性能,還具有較好的殺菌性能。
[Abstract]:Dressings are materials used to cover wounds to provide an enabling environment for wound healing. As we all know, the wound is susceptible to various bacterial infections, leading to wound deterioration, pus, etc. Therefore, the dressing used to cover the wound should have a relatively good antibacterial properties, thus can be used to prevent wound infection, However, most of the dressings currently used do not meet the antibacterial requirements. In this paper, three kinds of antimicrobial surfaces were constructed on the TPU electrospun film based on the electrospun polyurethane film, and the structure, composition and antibacterial properties of the surface before and after modification were studied. The main contents are as follows: firstly, monolayer bactericidal surface was constructed on TPU electrostatic spinning film. The multiwalled carbon nanotubes (MWCNT) were immobilized on the TPU electrospinning film by ultrasonic dispersion method to prepare the TPU/MWCNT electrostatic spinning film. The main conclusions obtained are as follows: X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and droplet morphology analyzer (DSA) to characterize the composition, morphology and wettability of TPU films before and after modification. It was proved that MWCNT was successfully immobilized on TPU electrostatic spinning film and that TPU/MWCNT electrospun film had good monolayer bactericidal property. Second, double-layer sterilization surface was constructed on TPU electrostatic spinning film. Van-MWCNT powder was prepared by activating carboxyl group of multiwalled carbon nanotubes and reacting with vancomycin hydrochloride (Vann) amino group. Then the TPA / MWCNT / Van-MWCNT electrospun films were prepared by ultrasound on the TPU electrospun films. The main conclusions obtained are as follows: (1) the surface chemical properties of TPU electrospun films before and after modification were characterized by ATR-FTIR spectra. It was proved that Van was grafted to MWCNT.2AATR-FTIR.The changes of color were characterized by SEM and DSA. The changes of surface chemical properties, color, morphology and wettability of TPU films before and after modification were characterized. It was proved that Van-MWCNT was successfully immobilized on the electrostatic spinning membrane of TPU) to test the minimum inhibitory concentration of Staphylococcus aureus. It was found that the minimum inhibitory concentration of Van-MWCNT was lower than that of MWCNT. The results showed that Van-MWCNT had better bactericidal properties. The TPU/Van-MWCNT electrospun film had better double-layer bactericidal properties. Third, the surface of TPU electrostatic spinning film was constructed. Polyethylene glycol (PEG) with anti-fouling function was grafted onto TPU electrostatic spinning film by ultraviolet grafting method, and then MWCNT was ultrasonic onto TPU-g-PEG electrostatic spinning film by ultrasonic cell pulverizer, and TPU-g-PEG/MWCNT electrostatic spinning film was obtained. The main conclusions obtained are as follows: (1) SEM and SEM have characterized the changes of surface chemical properties, wettability and morphology of TPU electrospun films before and after modification. It was proved that PEG was successfully grafted onto the TPU electrospun film. The color change and the SEM characterization of the surface chemical properties, wettability, color and morphology of the TPU electrospun film before and after modification were demonstrated. It was proved that MWCNT was successfully immobilized on the electrostatic spinning membrane of TPU-g-PEG. It is proved that PEG has good anti-adhesion function and reduces the toxicity of MWCNT to erythrocyte. The coating plate method proves that TPU-g-PEG/CNT electrospinning film not only has good antifouling property, but also has better bactericidal property.
【學(xué)位授予單位】：聊城大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：TQ340.64

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