本文關(guān)鍵詞：殼寡糖及其金屬離子配合物的合成研究　出處：《天津工業(yè)大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 殼寡糖 殼寡糖金屬配合物 工藝 配位比

【摘要】：殼寡糖(Chitooligosaccharides,簡稱COS)是從蝦蟹類生物外殼的甲殼素中提取,由2-10個(gè)氨基葡萄糖通過β-1,4糖苷鍵連接而成的低分子量殼聚糖。作為自然界中唯一帶正電荷、呈堿性、水溶性的多糖,殼寡糖不僅具有相對分子量小和可溶性高等優(yōu)點(diǎn),而且還擁有許多獨(dú)特的生理活性和功能性質(zhì)。殼寡糖分子中含有大量的羥基和氨基,它可以依靠氫鍵或鹽鍵形成具有類似網(wǎng)狀結(jié)構(gòu)的籠形分子,極易和金屬離子發(fā)生配位反應(yīng)生成殼寡糖金屬配合物,而這類配合物不僅具有殼寡糖的優(yōu)良性能,而且擁有金屬離子的相關(guān)特性,被廣泛應(yīng)用于保健食品生產(chǎn)與開發(fā),金屬分離及含量檢測、生物醫(yī)藥等領(lǐng)域。因此,殼寡糖金屬配合物具有重要的研究意義和實(shí)際應(yīng)用價(jià)值。本文研究了過氧化氫氧化制備殼寡糖的方法,考察了反應(yīng)溫度、時(shí)間以及過氧化氫濃度對降解效果的影響,并對所得產(chǎn)物進(jìn)行了粘均分子量測定,從而得到最佳的制備工藝條件為反應(yīng)溫度60℃,反應(yīng)時(shí)間6小時(shí),過氧化氫質(zhì)量分?jǐn)?shù)3%,在此條件下制得殼寡糖的粘均分子量為2.11×103左右;除此之外,本文合成了三種殼寡糖金屬配合物,分別是殼寡糖鐵配物(COS-Fe)、殼寡糖銅配物(COS-Cu)和殼寡糖鎳配物(COS-Ni)。利用紫外光譜和紅外光譜對產(chǎn)物進(jìn)行了表征分析,從而證實(shí)了所得產(chǎn)品即為殼寡糖金屬元素的配位產(chǎn)物,確定了和金屬離子Fe3+、Cu2+、Ni2+配位的優(yōu)化條件為配位溶液的pH值應(yīng)控制在4-5左右,綜合慮到實(shí)際工業(yè)生產(chǎn)中的生產(chǎn)周期和能量損耗等條件,反應(yīng)時(shí)間應(yīng)該控制在60min左右,反應(yīng)溫度控制在40-50℃;通過對殼寡糖金屬配位產(chǎn)物的熱重分析和元素分析,不僅證實(shí)了配位產(chǎn)物的存在,而且確定了殼寡糖和金屬離子進(jìn)行配位時(shí)的摩爾比值,通過測試數(shù)據(jù)的計(jì)算可以推斷出殼寡糖和鐵(Ⅲ)元素配位比值為3:1,殼寡糖和銅(Ⅱ)元素配位比值為2:1,殼寡糖和鎳(Ⅱ)元素配位比值為3:1。
[Abstract]:Chitosan oligosaccharide (Chitooligosaccharides, referred to as COS) is extracted from crab shell chitin biological, low molecular weight chitosan which are connected by 2-10 through -1,4 glucosamine beta glycosidic bond. As the only natural polysaccharide with positive charge, alkaline and water-soluble, chitosan oligosaccharide has not only the advantages of relatively small molecular weight and high solubility, but also has many unique physiological and functional properties. The chitosan oligosaccharide molecule contains a large number of hydroxyl groups and amino groups, it can rely on hydrogen bonds or salt bond formation with similar mesh structure of Cryptophane easily, and metal ion coordination reaction of chitosan metal complexes, such complexes not only has excellent performance of chitosan, and has characteristics of metal ions which is widely used in health food production and development, metal separation and content detection, biomedicine and other fields. Therefore, the metal complexes of chitosan oligosaccharides have important research significance and practical application value. This paper studies the method for the oxidation of hydrogen peroxide preparation of chitooligosaccharides. The effects of reaction temperature, time and concentration of hydrogen peroxide on the degradation effect, and the products were analyzed by viscosity average molecular weight determination, in order to get the optimal preparation conditions for the reaction temperature is 60 DEG C, the reaction time of 6 hours, 3% mass fraction of hydrogen peroxide, this prepared under the condition of chitosan oligosaccharide viscosity average molecular weight is about 2.11 * 103; in addition, three kinds of chitosan metal complexes were synthesized in this paper, chitosan iron complexes (COS-Fe), chitosan copper complexes (COS-Cu) and chitosan (COS-Ni) nickel complexes. The products were characterized by ultraviolet spectroscopy and infrared spectroscopy, which confirmed that the product is chitosan metal elements coordination product was determined and the metal ions of Fe3+, Cu2+, Ni2+ with the optimized conditions for the coordination of the pH value of the solution should be controlled at around 4-5, according to the actual comprehensive industrial production in the production cycle and energy loss and other conditions, the reaction time should be controlled at around 60min, the reaction temperature is controlled at 40-50 DEG C; the chitosan metal coordination product of thermogravimetric analysis and elemental analysis, not only confirmed the existence of product coordination, and to determine the chitosan and metal ions with a molar ratio when, through the calculation of test data can be inferred that oligochitosan and iron (III) element coordination ratio is 3:1, chitosan and copper (II) element coordination ratio is 2:1, chitosan and nickel (II) element coordination ratio is 3:1.
【學(xué)位授予單位】：天津工業(yè)大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：O641.4

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 田光磊;劉其海;胡文斌;賈振宇;林粵順;尹國強(qiáng);;水溶性殼聚糖制備方法的研究進(jìn)展[J];廣州化工;2015年20期

2 李小芳;馮小強(qiáng);孫長金;楊聲;;丁二�；瘹す烟窍⊥僚浜衔锏目寡趸钚詼y定[J];海洋科學(xué);2015年08期

3 梁慧培;覃小麗;鐘金鋒;;殼寡糖制備和生理活性的研究進(jìn)展[J];食品工業(yè)科技;2016年03期

4 戴文燦;周發(fā)庭;;電鍍含鎳廢水治理技術(shù)研究現(xiàn)狀及展望[J];工業(yè)水處理;2015年07期

5 陳構(gòu);王磊;林羽;;3種市售殼聚糖創(chuàng)傷修復(fù)類產(chǎn)品的粘均分子量測定[J];海峽藥學(xué);2015年01期

6 楊汝婷;郭志成;李紅霞;;殼聚糖對含鎳廢水的吸附研究[J];山東化工;2014年12期

7 王魯霞;吳延立;馬文平;;殼寡糖的制備方法及其在食品中的應(yīng)用現(xiàn)狀[J];安徽農(nóng)業(yè)科學(xué);2014年32期

8 楊俊玲;趙福龍;夏軍;張曉波;王璇;;優(yōu)質(zhì)殼聚糖/殼寡糖的制備工藝及水溶性殼寡糖Fe(Ⅲ)配合物的合成[J];天津工業(yè)大學(xué)學(xué)報(bào);2014年05期

9 王魯霞;馬文平;朱輝;范美霞;;殼寡糖的性能及其在化妝品中的應(yīng)用[J];科技創(chuàng)新與應(yīng)用;2014年27期

10 王曉暉;白海泉;烏蘭格日樂;;多糖金屬配合物的研究進(jìn)展[J];內(nèi)蒙古民族大學(xué)學(xué)報(bào)(自然科學(xué)版);2014年05期

，

本文編號(hào)：1342893