【摘要】：磺胺類抗生素是人工合成的高效廣譜抗菌藥,廣泛用于畜牧養(yǎng)殖、水產(chǎn)養(yǎng)殖和人類疾病治療中。但其長期排放和累積殘留會誘導(dǎo)產(chǎn)生抗生素抗性基因(ARGs)。ARGs作為一種新型的環(huán)境污染物,在環(huán)境中的持久性殘留、復(fù)制、傳播和擴(kuò)散比抗生素本身的危害更大。通過對磺胺類ARGs及耐藥微生物產(chǎn)生和傳播進(jìn)行綜述,提出"漸變→累積→突變"的ARGs演變模型。最后針對中國提出磺胺類ARGs未來的研究重點(diǎn)。
[Abstract]:Sulfonamides are synthetic and high-efficiency broad-spectrum antibiotics, which are widely used in animal husbandry, aquaculture and the treatment of human diseases. However, its long-term emission and cumulative residue will induce the production of antibiotic resistance gene (ARGs). As a new type of environmental pollutant, the persistent residue, replication, transmission and diffusion in the environment are more harmful than the antibiotic itself. Based on the review of the production and transmission of sulfonamides ARGs and drug-resistant microorganisms, a ARGs evolution model of "gradual cumulative mutation" was proposed. Finally, the future research focus of sulfonamides ARGs is put forward in China.
【作者單位】： 東華大學(xué)環(huán)境科學(xué)與工程學(xué)院;
【基金】：上海市科技攻關(guān)項(xiàng)目(No.033919457)
【分類號】：X592
，

本文編號：2519670