【摘要】：銅離子廣泛存在于環(huán)境和食品中,機(jī)體中游離銅離子含量增加可導(dǎo)致神經(jīng)系統(tǒng)功能紊亂和肝、腎損害等。目前銅離子的檢測(cè)方法主要有:原子吸收光譜法(AAS)、電感耦合等離子體原子發(fā)射光譜法(ICP-AES)和電感耦合等離子體質(zhì)譜法(ICPMS),這些方法雖然檢測(cè)結(jié)果準(zhǔn)確、靈敏度高,但儀器昂貴、樣品處理復(fù)雜且不能區(qū)分銅離子的存在形態(tài)。因此,探索基于銅離子特異性識(shí)別元件構(gòu)建的熒光或電化學(xué)檢測(cè)方法在游離銅快速特異性響應(yīng)中的應(yīng)用受到了廣泛青睞,其對(duì)應(yīng)的銅離子特異性識(shí)別元件如有機(jī)小分子、納米材料、生物分子等亦得到了不斷地豐富和發(fā)展。有機(jī)小分子設(shè)計(jì)靈活,納米材料響應(yīng)靈敏,生物分子特異性強(qiáng)、生物相容性好,此三者作為特異性識(shí)別元件在血清游離銅的檢測(cè)中具有廣闊的應(yīng)用前景。
[Abstract]:Copper ions widely exist in the environment and food. The increase of free copper ions in the body can lead to nervous system dysfunction and liver and kidney damage. At present, the main methods for the determination of copper ions are: (AAS), inductively coupled plasma atomic emission spectrometry (ICP-AES) and inductively coupled plasma-mass spectrometry (ICPMS),). These methods are accurate and sensitive, but the instruments are expensive. The sample treatment is complex and can not distinguish the existing forms of copper ions. Therefore, the application of fluorescent or electrochemical detection methods based on copper ion specific recognition elements to the rapid specific response of free copper has been widely used, and the corresponding copper ion specific recognition elements such as organic small molecules have been widely used. Nanomaterials and biomolecules have also been enriched and developed. The design of organic small molecules is flexible, the nanomaterials are sensitive, the biomolecules are specific, and the biocompatibility is good. As special recognition elements, these three elements have a broad application prospect in the detection of serum free copper.
【作者單位】： 首都醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;
【基金】：北京市教育委員會(huì)科技發(fā)展計(jì)劃重點(diǎn)項(xiàng)目(KZ201510025027) 首都醫(yī)科大學(xué)優(yōu)秀學(xué)術(shù)帶頭人及團(tuán)隊(duì)交流培養(yǎng)項(xiàng)目
【分類號(hào)】：X830
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本文編號(hào)：2213120