嗎啡對不同距離條件下大鼠信號追蹤和目標(biāo)追蹤的影響
[Abstract]:After the conditioned stimulus is briefly presented and disappeared, the reward is presented immediately. After multiple matches, the animal approaches to the conditioned stimulus (signal tracking) or the reward presentation device such as the food box (target tracking). The distance between conditioned stimulus and food box is an important variable that affects signal / target tracking response and impaired association learning. Addictive drugs can increase the incentive motivation of reward and then increase individual reward seeking behavior. Whether distance can attenuate the motivational amplification of addictive drugs through impaired association learning has not been reported. Autoshaping model was used to investigate the effects of morphine treatment on signal tracking and target tracking in rats at 830 and 60 cm distances. The results showed that: (1) signal tracking decreased with the increase of range, and target tracking was insensitive to range. (2) when acute morphine treatment was reduced by 8 ~ 30 and 60 cm, signal tracking was increased by 8 and 60 cm. Chronic morphine treatment reduced signal tracking and increased target tracking at 8 and 30 cm. In the regression test, the signal tracing was decreased by 8 and 60 cm before morphine exposure, but the target tracking was increased at 60 cm. (3) in discriminant reverse learning, the rats exposed to morphine at 30 and 60 cm preexposure preferred the old signals and the discriminant ability was impaired. Reduction of exposure to new signals in rats at 830 and 60 cm. These results suggest that less distance affects the signal tracking inhibition and target tracking enhancement of morphine, while the preexposure to morphine facilitates the damage to reverse learning. Distance is an important factor that facilitates addictive drugs to influence association learning rather than reverse their motivational amplification.
【作者單位】: 首都師范大學(xué)心理學(xué)系;淮陰師范學(xué)院教科院;
【基金】:國家自然科學(xué)基金(31470989) 江蘇省自然科學(xué)基金(BK20130415)資助
【分類號】:B845.4
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