【摘要】：成年海馬神經(jīng)元再生是指齒狀回顆粒下區(qū)的神經(jīng)干細(xì)胞發(fā)育為功能性神經(jīng)元的過(guò)程。在生命的早期經(jīng)歷應(yīng)激事件可損害成年期海馬神經(jīng)元再生,并引起學(xué)習(xí)記憶障礙。然而,目前關(guān)于早年應(yīng)激影響成年海馬神經(jīng)元再生的機(jī)制研究主要集中在糖皮質(zhì)激素及受體系統(tǒng),其相關(guān)調(diào)節(jié)分子與機(jī)制有待深入研究。本文闡述了主要的應(yīng)激因子(包括促腎上腺皮質(zhì)激素釋放激素及其受體等系統(tǒng))在早年應(yīng)激介導(dǎo)的成年海馬神經(jīng)元再生異常和海馬重塑中的潛在作用。
[Abstract]:The regeneration of adult hippocampal neurons refers to the development of neural stem cells from the subgranular area of dentate gyrus into functional neurons. Experiencing stress events at the early stage of life can damage the regeneration of hippocampal neurons in adulthood and lead to learning and memory impairment. However, the mechanism of early stress affecting the regeneration of adult hippocampal neurons is mainly focused on glucocorticoid and receptor system, and the related regulatory molecules and mechanisms need to be further studied. This paper describes the potential role of major stress factors (including corticotropin-releasing hormone and its receptor systems) in the early stress-mediated abnormal regeneration of adult hippocampal neurons and hippocampal remodeling.
【作者單位】： 浙江大學(xué)醫(yī)學(xué)院神經(jīng)生物學(xué)系衛(wèi)生部醫(yī)學(xué)神經(jīng)生物學(xué)重點(diǎn)實(shí)驗(yàn)室;
【基金】：中國(guó)自然科學(xué)基金面上項(xiàng)目(81471369)支持
【分類號(hào)】：B845.1
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本文編號(hào)：2157502