發(fā)布時(shí)間：2018-06-19 11:08

  本文選題：生物信息處理 + 抑郁癥��； 參考：《蘭州大學(xué)》2017年碩士論文

【摘要】：抑郁癥是目前危害人類健康最嚴(yán)重的心理疾病。它的主要癥狀為心情低落、喪失興趣和動(dòng)機(jī)減退。世界心理健康調(diào)查發(fā)現(xiàn)抑郁癥患者的人數(shù)逐年升高。預(yù)計(jì)到2020年將成為患病人數(shù)第二多的疾病,并且發(fā)病年齡越來越早。目前,對抑郁癥的發(fā)病原因仍不確定,對抑郁癥患者的診斷仍依靠醫(yī)生的主觀臨床判斷,誤診率高,且不容易在早期發(fā)現(xiàn)。因此迫切需要找到發(fā)病的原因及能準(zhǔn)確診斷的方法。事件相關(guān)電位(Event-related Potential,ERP)是由具有特殊意義的刺激誘發(fā)的腦電位,它是了解心理活動(dòng)的“窗口”。它是安全,便捷的檢測方法,具有時(shí)間分辨率高,簡單性,便攜性的特點(diǎn)。本文采用了情緒Stroop范式來誘發(fā)事件相關(guān)電位。并選取出抑郁癥患者與正常人各20人的69導(dǎo)腦電信號,采用疊加、平均的方法得到誘發(fā)電位,分析N1、P200成分所表示的認(rèn)知功能及抑郁癥可能存在的抑郁障礙。利用腦電源定位技術(shù)對抑郁患者的誘發(fā)成分進(jìn)行定位,進(jìn)而分析腦內(nèi)異常區(qū)域,為研究人員分析抑郁癥的發(fā)病原因,為醫(yī)生提供診斷及治療抑郁癥的理論支持。本文的主要工作為:(1)統(tǒng)計(jì)分析抑郁癥患者的行為數(shù)據(jù);(2)分析與選擇性注意相關(guān)的P200成分,發(fā)現(xiàn)抑郁癥患者存在負(fù)向情緒偏向;(3)利用標(biāo)準(zhǔn)低分辨率層析成像(sLORETA)腦電源定位算法定位精度高、可行度高的特點(diǎn),分析抑郁癥患者P200成分所表明的認(rèn)知障礙的異常腦區(qū),發(fā)現(xiàn)抑郁癥患者的認(rèn)知障礙主要存在于左側(cè)額葉及右側(cè)顳區(qū)。通過統(tǒng)計(jì)分析行為數(shù)據(jù)和ERP成分,發(fā)現(xiàn)抑郁癥患者的反應(yīng)時(shí)顯著增長,并且P200成分的波幅比正常人高,而ERP成分的潛伏期沒有顯著差異。sLORETA結(jié)果表明抑郁癥患者的左側(cè)額葉活動(dòng)性下降,右側(cè)額葉及顳葉的活動(dòng)性上升。以上結(jié)果表明抑郁癥患者對正性情緒注意不足,對負(fù)向情緒存在注意偏向,且顳葉受損致使抑郁癥患者難以調(diào)控自己的情緒。以上結(jié)論可以有效的幫助醫(yī)生進(jìn)行針對治療。
[Abstract]:Depression is the most serious psychological disease that endangers human health at present. Its main symptoms are depression, loss of interest and motivation. The World Mental Health Survey found that the number of depression patients increased year by year. The disease is expected to be the second most common disease by 2020, and the onset age is getting earlier. At present, the cause of depression is still uncertain, the diagnosis of depression still depends on the subjective clinical judgment of doctors, the misdiagnosis rate is high, and it is not easy to find in the early stage. Therefore, there is an urgent need to find the cause of the disease and to accurately diagnose the method. Event-related potentials (Event-related potentials) are brain potentials evoked by stimuli of special significance, which are "windows" for understanding psychological activities. It is a safe and convenient detection method with high time resolution, simplicity and portability. The emotional Stroop paradigm was used to induce event-related potentials. The 69 lead EEG signals of 20 patients with depression and 20 normal subjects were selected and the evoked potentials were obtained by superposition and average method. The cognitive function expressed by the component of N1P 200 and the possible depression disorder in depression were analyzed. The brain power source localization technique was used to locate the evoked components of depressive patients, and then to analyze the abnormal regions of the brain, to provide theoretical support for the diagnosis and treatment of depression for the researchers to analyze the causes of depression. The main work of this paper is to analyze the P200 components associated with selective attention. It was found that there was a negative emotional bias in patients with depression. (3) using standard low resolution tomography (Lorreta) algorithm to locate the brain power source with high accuracy and high feasibility, the abnormal brain regions of cognitive disorders indicated by P200 components in depression patients were analyzed. It was found that cognitive impairment in patients with depression mainly occurred in left frontal lobe and right temporal area. Through statistical analysis of behavioral data and ERP components, it was found that the response time of depression patients increased significantly, and the amplitude of P200 component was higher than that of normal people. However, there was no significant difference in latency of ERP components. SLORETA results showed that the activity of left frontal lobe decreased, while that of right frontal lobe and temporal lobe increased in patients with depression. These results indicate that the depression patients pay less attention to the positive emotion and have the attention bias to the negative emotion, and the temporal lobe damage makes it difficult for the depression patients to regulate their own emotion. The above conclusion can effectively help doctors to carry out targeted treatment.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：B845

【參考文獻(xiàn)】

相關(guān)期刊論文 前9條

1 梁靜;曾波濤;孟祥軍;;首發(fā)抑郁癥患者認(rèn)知功能與事件相關(guān)電位P300研究[J];中國健康心理學(xué)雜志;2015年02期

2 鐘智勇;陳霞;呂佑輝;廖曉玲;王\，

本文編號：2039688