本文關(guān)鍵詞：黑豆洗方外用治療手部濕疹的臨床療效觀察及作用機(jī)理探討，由筆耕文化傳播整理發(fā)布。

黑豆洗方外用治療手部濕疹的臨床療效觀察及作用機(jī)理探討

黑豆洗方外用治療手部濕疹的臨床療效觀察及作用機(jī)理探討

手部濕疹是皮膚科臨床的常見病、多發(fā)病，中藥治療該病療效顯著。本課題應(yīng)用中醫(yī)理論及現(xiàn)代技術(shù)從臨床和實驗兩方面觀察了導(dǎo)師用于臨床多年的經(jīng)驗方——黑豆洗方外用治療手部濕疹的臨床療效并對其作用機(jī)理進(jìn)行了初步探討。臨床觀察中，黑豆洗方外用治療手部濕疹59例，，治愈率32.2％、總有效率67.8％，與去炎松尿素軟膏組療效相當(dāng)，且在對各種臨床癥狀及自覺癥狀的改善方面及遠(yuǎn)期療效明顯優(yōu)于后者。實驗部分通過抗炎實驗、抗過敏性接觸性皮炎實驗、止癢實驗和對兔皮膚刺激實驗說明該藥外用具有抗Ⅳ型變態(tài)反應(yīng)、止癢的作用，且對皮膚無刺激性。本研究認(rèn)為黑豆洗方外用治療手部濕疹療效肯定，復(fù)發(fā)率低，其良好的潤膚、止癢、抗Ⅳ型變態(tài)反應(yīng)作用為本病的治療提供了部分臨床及理論依據(jù)。

【Abstract】 Hand eczema(HE) is a common dermatologic disease.Traditional Chinese Medicine (TCM) has broad prospects in treating it.Based on my tutor ,professor Du Xixian’s abundant clinical experiences and the reference of ancient and modern bibliography,the dissertation is aimed to select an effective external lotion -Heidou lotion in treating hand eczema and to study the treating mechanism of it.The project is made up of two parts:the clinical study and the experimental study. In clinical study, 93 patients of HE were divided into two groups at random: 59 cases were treated with Heidou totion while the other 34 cases were treated with Triamcinolone Acetonide Acetate Urea Cream.Result: the HD lotion group’s clinical cure rate is 32.2% and the total effective rate is 67.8%,while the control group’s clinical cure rate is 20.59% and the total effective rate is 52.94%.These two have no notable difference through statistical analysis. And the curative effect of the HD lotion group after 3 months is better than that of the control group.In experimental study ,through experiments on animal models results show that Heidou lotion has little anti-acurate inflammation effect and notable anti-IV hypersensitivity effect with little irritation to the skin.Through all these studies we can see that with good clinical effect and definite anti-IV hypersensitivity effect,HD lotion is a economical external TCM compound in treating HE.But we still have much work to do .For example, we must further the experimental studies in order to know the exact treating mechnism of HD lotion.

【關(guān)鍵詞】 手部濕疹； 中醫(yī)藥療法； 臨床研究； 實驗研究；
【Key words】 hand eczema； external therapy of TCM； clinical observation； experimental study；

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  本文關(guān)鍵詞：黑豆洗方外用治療手部濕疹的臨床療效觀察及作用機(jī)理探討，由筆耕文化傳播整理發(fā)布。

本文編號：99503