【摘要】：目的:探討冠心病患者頸動(dòng)脈粥樣硬化的超聲特征及其與病情嚴(yán)重程度的相關(guān)性。方法:收集在本院接受治療的冠心病患者180例作為觀察組,根據(jù)冠狀動(dòng)脈狹窄程度分為單支病變組50例、雙支病變組72例、三支病變組58例;另取同期在本院進(jìn)行體檢的健康人50例作為對(duì)照組。采用頸動(dòng)脈超聲檢測(cè)頸動(dòng)脈粥樣硬化參數(shù),采用心臟彩色多普勒超聲檢測(cè)心功能參數(shù),采用酶聯(lián)免疫吸附法(ELISA)檢測(cè)血清內(nèi)皮功能指標(biāo),采用Pearson檢驗(yàn)分析頸動(dòng)脈超聲參數(shù)與心功能、內(nèi)皮功能的相關(guān)關(guān)系。結(jié)果:觀察組頸動(dòng)脈超聲參數(shù)β、Ep、AC、PWVβ值高于對(duì)照組,隨著冠脈病變程度增加,β、Ep、AC、PWVβ值改變程度加劇(P0.05);觀察組心功能參數(shù)LVEDD、LVESD值高于對(duì)照組,LVEF值低于對(duì)照組,隨著冠脈病變程度增加,LVEDD、LVESD、LVEF值改變程度加劇(P0.05);觀察組的內(nèi)皮功能指標(biāo)ET-1、vWF水平高于對(duì)照組,NO水平低于對(duì)照組,隨著冠脈病變程度增加,ET-1、vWF、NO水平改變程度加劇(P0.05)。冠心病患者頸動(dòng)脈超聲參數(shù)β、Ep、AC、PWVβ值與心功能參數(shù)、內(nèi)皮功能指標(biāo)水平均呈直接相關(guān)關(guān)系。結(jié)論:冠心病患者頸動(dòng)脈粥樣硬化的超聲參數(shù)水平與病變嚴(yán)重程度直接相關(guān),可作為早期病情判斷的無創(chuàng)、可靠手段。
[Abstract]:Objective: to investigate the ultrasonic features of carotid atherosclerosis and its correlation with severity of coronary heart disease. Methods: 180 cases of coronary heart disease treated in our hospital were divided into three groups according to the degree of coronary artery stenosis: 50 cases in single vessel group, 72 cases in double vessel group and 58 cases in three vessel group. Another 50 healthy people who were examined in our hospital at the same time were taken as control group. Carotid artery ultrasound was used to detect carotid atherosclerosis parameters, heart color Doppler ultrasound was used to detect cardiac function parameters, and enzyme linked immunosorbent assay (ELISA) was used to detect serum endothelial function. The relationship between carotid ultrasound parameters and cardiac function and endothelial function was analyzed by Pearson test. Results: the parameters of carotid artery ultrasound 尾 and Ep,AC,PWV 尾 in the observation group were higher than those in the control group, and the changes of 尾 and Ep,AC,PWV 尾 were aggravated with the increase of coronary artery lesion (P0.05), the LVEDD,LVESD value of cardiac function parameter in the observation group was higher than that in the control group, and the LVEF value was lower than that in the control group. With the increase of coronary lesions, the change of LVEDD,LVESD,LVEF increased (P0.05); the ET-1,vWF level of endothelial function in the observation group was higher than that of the control group, and the level of NO was lower than that of the control group. With the increase of the severity of coronary artery lesion, the ET-1,vWF,NO level was increased (P0.05). Carotid ultrasound parameters 尾 and Ep,AC,PWV 尾 were directly correlated with cardiac function and endothelial function in patients with coronary heart disease. Conclusion: the ultrasonic parameters of carotid atherosclerosis in patients with coronary heart disease are directly related to the severity of the disease and can be used as a noninvasive and reliable method for early diagnosis of the disease.
【作者單位】： 鄭州大學(xué)第五附屬醫(yī)院超聲診斷科;
【基金】：陜西省教育廳基金項(xiàng)目(12JK0701)~~
【分類號(hào)】：R541.4;R445.1

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