【摘要】：目的探索血氧水平依賴(BOLD)、體素內(nèi)不相干運(yùn)動(dòng)(IVIM)、動(dòng)脈自旋標(biāo)記(ASL)磁共振技術(shù)研究小腿肌肉缺血灌注的可行性。方法對(duì)15名健康志愿者的一側(cè)大腿根部給予不同程度壓力,分別在加壓前(P_0),收縮壓基礎(chǔ)上20 mmHg(P_(20))、收縮壓基礎(chǔ)上40 mmHg(P_(40))和釋放壓力后(Precovery)在3.0 T磁共振掃描儀上進(jìn)行雙小腿BOLD、IVIM和ASL成像。通過相應(yīng)后處理軟件對(duì)加壓腿和對(duì)側(cè)未加壓小腿脛骨前肌、腓骨長肌、比目魚肌、腓腸肌的BOLD-T_2~*值、IVIM-f值和ASL-BF值進(jìn)行測量。通過經(jīng)皮氧分壓儀在成像區(qū)域測得4種狀態(tài)下的經(jīng)皮氧分壓(TcPO_2)值作為對(duì)比參考。結(jié)果 4種不同狀態(tài)下,加壓側(cè)小腿肌肉BF值、f值和T_2~*值都具有統(tǒng)計(jì)學(xué)意義(P0.05),但脛骨前肌f值沒有統(tǒng)計(jì)學(xué)意義。在P_(20)和P_(40)這兩種狀態(tài)下,加壓側(cè)小腿肌肉BF值和T_2~*值均明顯低于加壓前(P0.008)而f值均高于加壓前。在P_(40)狀態(tài)下,加壓側(cè)和對(duì)照側(cè)相比,除脛骨前肌T_2~*值無統(tǒng)計(jì)學(xué)意義外,其余肌肉BF值、f值和T_2~*值具有顯著性差異。在P_(20)狀態(tài)下加壓側(cè)和對(duì)照側(cè)相比,兩組腓腸肌的BF值和T_2~*值存在顯著性差異。釋放壓力后所有的值趨向基線值。BF值和T_2~*值與TcPO_2呈正相關(guān)(分別ρ=0.465,P=0.001、ρ=0.522,P0.001〗)。f值與TcPO_2呈負(fù)相關(guān)(ρ=-0.351,P=0.018)。結(jié)論 ASL-BF、BOLDT_2~*、IVIM-f值的變化可以評(píng)估小腿肌肉血流灌注情況,BF值和T_2~*值與TcPO_2值具有正相關(guān)性而f值與TcPO_2值具有負(fù)相關(guān)性。
[Abstract]:Objective to explore the feasibility of using spin-labeled (IVIM), artery spin-labeled (ASL) magnetic resonance technique to study the myocardial ischemia and perfusion of calf muscles in (BOLD), voxel dependent blood oxygen level. Methods 15 healthy volunteers were subjected to different degrees of pressure on the root of one thigh. BOLD,IVIM and ASL were performed on the 30-T MRI scanner before compression, 20 mmHg on the basis of systolic pressure (40 mmHg (P40) on the basis of P20), systolic blood pressure and 40 mmHg (P40) on the basis of P20), systolic blood pressure, respectively) on 3.0T MRI scanner. The BOLD-T_2~* values of tibial anterior muscle, fibula longus muscle, soleus muscle and gastrocnemius muscle were measured by corresponding post-processing software. The transdermal oxygen partial pressure (TcPO_2) values in four states were measured by the transdermal oxygen partial pressure meter in the imaging region as a reference. Results in the four different states, the BF value and the T _ 2 value of the leg muscles in the compression side were statistically significant (P0.05), but the f value of the tibial anterior muscle was not statistically significant. Under the condition of P20 and P40, the values of BF and T _ 2T _ 2 * of the leg muscles in the compression side were significantly lower than those before compression (P 0.008), and the f values were higher than those before compression. Under P40 condition, there was significant difference in BF value between the compression side and the control side, except for the tibial anterior muscle T _ 2T _ 2 *, and there was a significant difference between the BF value and T _ 2T _ 2 value of the other muscles. There was a significant difference in BF value and T _ 2T value of gastrocnemius muscle between the pressurized side and the control side in P20 state. All values after release of pressure tended to baseline value. BF value and T _ 2C _ (2) * value were positively correlated with TcPO_2 (蟻 ~ (0.465U) P ~ (0.001), 蟻 ~ (0. 522) P ~ (0.001). F values were negatively correlated with TcPO_2 (蟻 ~ (-0.351g) P ~ (0.018). Conclusion the changes of ASL-BF,BOLDT_2~*,IVIM-f value can be used to evaluate the blood perfusion of calf muscle. There is a positive correlation between BF value and TcPO_2 value, but a negative correlation between f value and TcPO_2 value.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬仁濟(jì)醫(yī)院放射科;
【基金】：上海市重點(diǎn)學(xué)科建設(shè)項(xiàng)目資助(編號(hào):S30203) 上海高校示范性全英語課程建設(shè)基金資助項(xiàng)目(滬教委高[2015]15號(hào))
【分類號(hào)】：R445.2;R543.5

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