發(fā)布時(shí)間：2018-06-28 00:52

  本文選題：肝臟 + 纖維化　； 參考：《現(xiàn)代生物醫(yī)學(xué)進(jìn)展》2017年05期

【摘要】：目的:探討Strain Histogram組織彌散度成像技術(shù)在慢性肝損傷程度無創(chuàng)診斷中的臨床價(jià)值。方法:應(yīng)用Strain Histogram組織彌散度成像技術(shù)定量檢測(cè)180例慢性肝炎(病毒性肝炎105例,非病毒性肝炎75例)患者肝臟彈性特征值,對(duì)照病理,分析肝臟彈性特征值與肝纖維化及肝臟炎癥程度的相關(guān)性。結(jié)果:180例慢性肝炎患者LF指數(shù)用于判斷輕度與中重度纖維化的診斷界值為2.785,LF指數(shù)越大,纖維化程度越重,靈敏度76.6%,特異度48.9%;LF指數(shù)用于判斷輕度與中重度炎癥的診斷界值為2.925,LF指數(shù)越大,炎癥程度越重,靈敏度73.2%,特異度56.8%。105例病毒性肝炎患者LF指數(shù)用于判斷輕度與中重度纖維化的診斷界值為2.975,LF指數(shù)越大,纖維化程度越重,靈敏度69.2%,特異度67.1%;LF指數(shù)用于判斷輕度與中重度炎癥的診斷界值為2.915,LF指數(shù)越大,炎癥程度越重,靈敏度80.0%,特異度57.8%。75例非病毒性肝炎患者LF指數(shù)與肝纖維化和炎癥程度不具有相關(guān)性。結(jié)論:LF指數(shù)可以反映肝臟纖維化及炎癥程度,診斷靈敏度高,LF指數(shù)越大,肝纖維化及炎癥程度越重。
[Abstract]:Objective: to evaluate the clinical value of histogram tissue diffusion imaging in noninvasive diagnosis of chronic liver injury. Methods: the characteristic values of liver elasticity in 180 patients with chronic hepatitis (105 patients with viral hepatitis and 75 patients with non-viral hepatitis) were detected by histogram tissue diffusion imaging. To analyze the correlation between the characteristic value of liver elasticity and the degree of liver fibrosis and inflammation. Results the LF index of 180 patients with chronic hepatitis was used to determine the diagnostic threshold of mild and moderate fibrosis. The larger the LF index was, the more the degree of fibrosis was. Sensitivity 76. 6. The specificity of LF index is 48. 9%. The diagnostic threshold of mild and moderate to severe inflammation is 2. 925% LF index is higher, the degree of inflammation is more serious. Sensitivity 73.2%, specificity 56.8%. 105 patients with viral hepatitis, LF index was used to judge mild and moderate fibrosis. The diagnostic threshold value of LF index was 2.975%. The higher the LF index was, the more serious the fibrosis degree was. The sensitivity 69.2%, the specificity 67.1% LF index is used to judge the mild and moderate severe inflammation, the greater the diagnostic threshold value is 2.915% LF index, the more severe the inflammation degree. The sensitivity was 80.0 and the specificity was 57.8%. There was no correlation between LF index and the degree of liver fibrosis and inflammation in 75 patients with non-viral hepatitis. Conclusion the higher the sensitivity of diagnosis, the greater the degree of liver fibrosis and inflammation.
【作者單位】： 解放軍第三0二醫(yī)院超聲科;
【基金】：解放軍302醫(yī)院創(chuàng)新基金項(xiàng)目(YNKT2012033)
【分類號(hào)】：R575;R445.1

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