發(fā)布時(shí)間：2018-06-11 16:21

  本文選題：孕早期 + 超聲異常指標(biāo)�。� 參考：《中國(guó)醫(yī)學(xué)前沿雜志(電子版)》2017年02期

【摘要】：目的探討孕早期不同超聲異常指標(biāo)在篩查胎兒染色體異常中的臨床價(jià)值。方法選取2006年4月至2016年4月于本院產(chǎn)檢的孕早期(孕11~14周)孕婦為研究對(duì)象,超聲檢查發(fā)現(xiàn)胎兒異常孕婦147例,所有孕婦均行羊水與絨毛染色體核型分析。統(tǒng)計(jì)分析不同超聲異常指標(biāo)對(duì)應(yīng)的胎兒染色體異常檢出率。結(jié)果孕早期超聲異常指標(biāo)包括心臟畸形、全身皮膚水腫、鼻骨異常、靜脈導(dǎo)管a波倒置、頸部淋巴水囊瘤、頸部透明層(nuchal translucency,NT)增厚及臍膨出。心臟畸形的染色體異常檢出率為80.00%(8/10),以18-三體與21-三體為主;全身皮膚水腫的染色體異常檢出率為68.00%(17/25),以18-三體、45,X、21-三體為主;鼻骨異常的染色體異常檢出率為75.00%(6/8),以18-三體、21-三體為主;靜脈導(dǎo)管a波倒置的染色體異常檢出率為71.43%(5/7),以21-三體、18-三體、45,X為主;頸部淋巴瘤的染色體異常檢出率為66.67%(6/9),以45,X、21-三體為主;NT增厚的染色體異常檢出率為37.80%(31/82),以21-三體、45,X、18-三體為主;臍膨出的染色體異常檢出率為66.67%(4/6),以21-三體、45,X、18-三體為主。結(jié)論心臟畸形、全身皮膚水腫、NT增厚、頸部淋巴水囊瘤是染色體異常檢出率最高的4種孕早期超聲異常指征。同時(shí)合并與染色體異常相關(guān)的早孕期超聲異常指征越多,染色體異常檢出率越高。
[Abstract]:Objective to investigate the clinical value of different ultrasound abnormal indexes in early pregnancy in screening fetal chromosome abnormalities. Methods from April 2006 to April 2016, 147 pregnant women with fetal abnormalities were examined in our hospital from April 2006 to April 2016. The chromosome karyotypes of amniotic fluid and villi were analyzed in all pregnant women. The detection rate of fetal chromosomal abnormalities corresponding to different ultrasonic abnormalities was statistically analyzed. Results in early pregnancy, the abnormal indexes of ultrasound included cardiac malformation, systemic skin edema, abnormal nasal bone, inversion of a wave of venous catheter, cervical lymphatic sac tumor, thickening of transparent layer of neck (NTN) and umbilical herniation. The detection rate of chromosomal abnormality in cardiac malformation was 80.005 / 10, mainly in 18-trisomy and 21-trisomy, in the case of systemic skin edema, the detection rate of chromosome abnormality was 68.00 / 25, and that of 18-trisomy was 45X / 21- trisomy. The detection rate of abnormal chromosome in nasal bone was 75.00 / 8, mainly in 18-trisomy 21- trisomy, 71.43A wave inversion was 71.43T / 7, in 21-trisomy 18-trisomy 45X; The detection rate of chromosomal abnormality in cervical lymphoma was 66.67 / 60.The detection rate of chromosome abnormality with NT thickening was 37.80 / 82, that of 21- trisomy 45 was mainly trisomy 18, that of umbilical exudation was 66.674r-1 / 6, and that of trisomy 21- trisomy was 45X / 18- trisomy 45.The detection rate of chromosomal abnormality was 66.674r-1 / 6m, and that of T-trisomy 45-trisomy was 66.674r-1 / 69.The detection rate of chromosomal abnormality was 37.80m / 82a, 45.5X / 18-trisomy was dominant. Conclusion Cardiac malformation, systemic skin edema and NT thickening, cervical lymphoid sac tumor are the highest detection rate of chromosomal abnormalities in early pregnancy. At the same time, the more signs of abnormal ultrasound in early pregnancy associated with chromosomal abnormalities, the higher the detection rate of chromosomal abnormalities.
【作者單位】： 湖南省婦幼保健院超聲科;
【分類(lèi)號(hào)】：R714.5;R445.1

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本文編號(hào)：2005913