本文選題：乙型肝炎 + HBV��； 參考：《臨床和實(shí)驗(yàn)醫(yī)學(xué)雜志》2017年03期

【摘要】：目的探討乙型肝炎患者病毒復(fù)制指標(biāo)(HBV DNA)與乙肝標(biāo)志物及肝功能的關(guān)系。方法對(duì)68例乙型肝炎患者采用電化學(xué)發(fā)光法檢測(cè)血清中的乙型肝炎e抗體(HBe Ab)、核心抗體(HBc Ab)、e抗原(HBe Ag)、表面抗體(HBs Ab)、表面抗原(HBs Ag)水平。采用實(shí)時(shí)熒光定量法檢測(cè)血清中的HBV DNA水平,采用全自動(dòng)生化儀檢測(cè)血清中的天門冬氨酸氨基轉(zhuǎn)移酶(AST)、丙氨酸氨基轉(zhuǎn)移酶(ALT)和膽堿酯酶(CHE)。結(jié)果 HBs Ag/HBe Ag/HBc Ab陽(yáng)性組(大三陽(yáng)組)患者血清中的HBV DNA陽(yáng)性率以及定量結(jié)果高于其他組(P0.05);HBe Ag陽(yáng)性組中HBVDNA的陽(yáng)性表達(dá)率高于HBe Ag陰性組中HBV DNA的陽(yáng)性表達(dá)率(P0.05);HBV DNA載量≤10~3、10~3HBV DNA載量106、HBV DNA載量≥106的患者間血清AST和ALT水平差異有統(tǒng)計(jì)學(xué)意義(P0.05),隨著HBVDNA載量的增加血清AST和ALT顯著增加;但三組間的CHE差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論乙型肝炎患者HBV DNA水平和乙肝患者的病毒復(fù)制情況、炎癥程度有著密切的聯(lián)系,但需要與乙肝標(biāo)志物結(jié)合才能更加客觀和準(zhǔn)確的評(píng)價(jià)患者的病情變化和嚴(yán)重程度。
[Abstract]:Objective to investigate the relationship between HBV DNA and HBV markers and liver function in patients with hepatitis B. Methods 68 patients with hepatitis B were detected by electrochemiluminescence assay (ECL) to detect the levels of HBe Aban, HBe Agn, HBs Abn, HBeAg and HBeAg in the serum of 68 patients with hepatitis B. The levels of HBV DNA in serum were detected by real-time fluorescence quantitative method. Aspartate aminotransferase (ASTT), alanine aminotransferase (alt) and cholinesterase (CHEE) in serum were detected by automatic biochemical instrument. Results the positive rate and quantitative results of HBV DNA in serum of patients with HBs Ag / HBe / HBc Ab positive group were higher than those in other groups (P 0.05 + HBe Ag positive group) than those in HBe Ag negative group (P 0.05) and the positive rate of HBV DNA loaded with HBV DNA was higher than that in HBe Ag negative group. There was significant difference in serum AST and alt levels between patients with HBV DNA load 鈮，

本文編號(hào)：1992774