本文選題：乳腺腫瘤 + 超聲檢查�。� 參考：《中國(guó)臨床醫(yī)學(xué)影像雜志》2017年05期

【摘要】：目的:初步探討超聲造影時(shí)間-強(qiáng)度曲線(xiàn)(TIC)在三陰性乳腺癌(TNBC)鑒別診斷中的應(yīng)用價(jià)值。方法:以病理及免疫組化結(jié)果為金標(biāo)準(zhǔn),分析126例患者共126個(gè)病灶及其周?chē)M織的超聲造影TIC。結(jié)果:TNBC病灶增強(qiáng)強(qiáng)度及曲線(xiàn)下面積均大于非TNBC(P0.001),其ROC曲線(xiàn)下面積分別為0.857,0.807,初步界定當(dāng)病灶增強(qiáng)強(qiáng)度11.99時(shí),其為T(mén)NBC可能性大(靈敏度88%,特異度80%),當(dāng)病灶曲線(xiàn)下面積684.31時(shí),其為T(mén)NBC可能性大(靈敏度60%,特異度95%);TNBC組周?chē)M織與非TNBC組周?chē)M織對(duì)比,其基礎(chǔ)強(qiáng)度較低,增強(qiáng)強(qiáng)度較大(P0.05);與周?chē)M織比較,TNBC組病灶的峰值強(qiáng)度、增強(qiáng)強(qiáng)度、上升支斜率、峰值減半差值時(shí)間、曲線(xiàn)下面積大于周?chē)M織,兩兩比較有統(tǒng)計(jì)學(xué)差異(P0.05),但不同于非TNBC,其始增時(shí)間、達(dá)峰時(shí)間、基礎(chǔ)強(qiáng)度與周?chē)M織比較無(wú)明顯差異。結(jié)論:應(yīng)用TIC定量分析可在一定程度上幫助鑒別TNBC與非TNBC。
[Abstract]:Objective: to evaluate the value of time intensity curve (TIC) in differential diagnosis of triple negative breast cancer. Methods: TICs of 126 lesions and surrounding tissues in 126 patients were analyzed by using pathological and immunohistochemical results as gold standard. Results both the enhancement intensity and the area under the curve were larger than those of the non-TNBCU (P 0.001), and the areas under the ROC curve were 0.857 / 0.807, respectively. It was preliminarily defined that when the enhancement intensity of the lesion was 11.99, it was more likely to be TNBC (sensitivity 88%, specificity 80%), and when the area under the focus curve was 684.31, The results showed that there was a great possibility of TNBC (sensitivity 60%, specificity 95%). Compared with non-TNBC group, the basic strength was lower and the enhancement intensity was larger (P 0.05), and the peak intensity, enhancement intensity and ascending branch slope were higher than those in the surrounding tissue. The area under the curve was larger than that of the surrounding tissue, and the difference was statistically significant (P 0.05), but different from that of non-TNBC, there was no significant difference in initial increase time, peak reaching time and base strength between the two groups. Conclusion: quantitative analysis of TIC can help to distinguish TNBC from non TNBC to some extent.
【作者單位】： 廣西壯族自治區(qū)人民醫(yī)院超聲科;
【基金】：廣西科學(xué)研究與技術(shù)開(kāi)發(fā)計(jì)劃項(xiàng)目(No.桂科攻14124004-1-13) 廣西醫(yī)藥衛(wèi)生自籌經(jīng)費(fèi)計(jì)劃課題(No.Z2016585)
【分類(lèi)號(hào)】：R445.1;R737.9

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