本文選題：NAT反應(yīng)性 + 獻(xiàn)血者歸隊　； 參考：《中國輸血雜志》2017年07期

【摘要】：目的實驗探討NAT反應(yīng)性獻(xiàn)血者歸隊的方法和可行性。方法挑選2012年-2014年ELISA無反應(yīng)性NAT反應(yīng)性獻(xiàn)血者,獲其知情同意后召回收集血樣。先進(jìn)行常規(guī)ELISA(HBs Ag、抗-HCV、抗-HIV和抗-TP)和NAT(HBV-DNA、HCV-RNA和HIV-RNA)檢測。若均為無反應(yīng)性的,再繼續(xù)進(jìn)行高靈敏度的化學(xué)發(fā)光法補(bǔ)充試驗(HBs Ag、HBe Ag、抗-HBs、抗-HBc、抗-HBe、抗-HCV、抗-HIV)。結(jié)果召回獻(xiàn)血者30人,經(jīng)檢測仍為ELISA無反應(yīng)性NAT反應(yīng)性的11例,擬建議永久屏蔽;ELISA、NAT均為無反應(yīng)性的19例,化學(xué)發(fā)光法檢測89.5%為抗-HBc和/或抗-HBe反應(yīng)性(12例抗-HBc、抗-HBe均反應(yīng)性,5例抗-HBe反應(yīng)性)�？�-HBc或抗-HBe反應(yīng)性存在感染風(fēng)險,擬建議永久屏蔽。2例所有項目均無反應(yīng)性,擬建議可以考慮歸隊。結(jié)論 NAT反應(yīng)性獻(xiàn)血者歸隊有其必要性和現(xiàn)實意義,但為血液安全考慮,應(yīng)建立1個謹(jǐn)慎的適合中國人群的NAT反應(yīng)性獻(xiàn)血者歸隊方案。
[Abstract]:Objective to explore the method and feasibility of NAT reactive blood donors. Methods ELISA nonreactive NAT donors were selected from 2012 to 2014 and recalled to collect blood samples with their informed consent. Routine ELISA(HBs Ag, anti-HCV, anti-HIV and anti-TP-) and Nat HBV-DNA HCV-RNA and HIV-RNA were first detected. If all of them were nonreactive, the high sensitivity chemiluminescence supplementation test (HBs Ag-HBe, anti-HBs, anti-HBc, anti--HBe, anti-HCV, anti-HIVP) was carried out. Results Thirty blood donors were recalled, 11 of them were still ELISA nonreactive NAT reactivity, 19 of them were suggested to be permanently shielded from EISANAT. By chemiluminescence assay, 12 cases of anti-HBc and / or anti-HBe reactivity were detected by chemiluminescence assay, and 5 cases of anti-HBe reactivity were detected by anti-HBe reactivity. Anti-HBc or anti-HBe reactivity is at risk of infection. It is suggested that all items should be permanently shielded. Conclusion it is necessary and practical for NAT reactive blood donors to return to China, but for the sake of blood safety, it is necessary to establish a prudent scheme for NAT reactive blood donors in China.
【作者單位】： 上海市血液中心;
【分類號】：R446.6
，

本文編號：1884331