本文選題：尿毒癥 + 高通量血液透析�。� 參考：《海南醫(yī)學(xué)院學(xué)報(bào)》2017年06期

【摘要】：目的:研究高通量和低通量血液透析對(duì)尿毒癥患者體內(nèi)毒副代謝產(chǎn)物及細(xì)胞因子的影響。方法:選擇在我院接受高通量血液透析治療的50例尿毒癥患者和接受低通量血液透析治療的140例尿毒癥患者分別作為高通量組和低通量組。透析前和透析后分別采集血清,測(cè)定毒副代謝產(chǎn)物、鈣磷代謝指標(biāo)以及細(xì)胞因子的含量。結(jié)果:透析后3個(gè)月時(shí),兩組血清中Ca含量與透析前比較無(wú)顯著性差異,BUN、Scr、β2-MG、sTfR、P、PTH、AKP的含量均顯著低于透析前;透析后3個(gè)月時(shí),高通量組血清中BUN、Scr、Ca的含量與低通量組比較無(wú)顯著性差異,β2-MG、sTfR、P、PTH、AKP、TNF-α、IL-1β、IL-6、IL-8、IL-10的含量顯著低于低通量組。結(jié)論:與低通量血液透析相比較,高通量血液透析治療尿毒癥能夠更為有效地清除中分子、大分子毒素的清除效果并糾正鈣磷代謝紊亂、減輕微炎癥狀態(tài)。
[Abstract]:Aim: to study the effects of high-and low-flux hemodialysis on toxic by-metabolites and cytokines in patients with uremia. Methods: 50 patients with uremia and 140 patients with uremia treated with low flux hemodialysis were selected as high flux group and low flux group respectively. Serum samples were collected before and after dialysis, and the contents of toxic metabolites, calcium and phosphorus metabolites and cytokines were measured. Results: at 3 months after dialysis, there was no significant difference in serum Ca content between the two groups compared with that before dialysis. The contents of BUNC Scrand 尾 2-MGG TfRU PTHN AKP were significantly lower than those before dialysis, and at 3 months after dialysis, there was no significant difference between the two groups. There was no significant difference between the high flux group and the low flux group in the content of BUNGN Scrcr Ca, but the content of 尾 2 MGN TfRU PPTHN TNF- 偽 and IL-1 尾 IL 6, IL 8 and IL 8 IL-10 was significantly lower than that in the low flux group. The results showed that there was no significant difference between the high flux group and the low flux group. Conclusion: compared with low-flux hemodialysis, high-throughput hemodialysis can effectively remove mesomolecules and macrotoxins, correct the disorder of calcium and phosphorus metabolism, and alleviate the microinflammation.
【作者單位】： 河北省滄州中西醫(yī)結(jié)合醫(yī)院腎病科;
【基金】：河北省重點(diǎn)科技攻關(guān)基金資助項(xiàng)目(05463)~~
【分類號(hào)】：R692.5

【相似文獻(xiàn)】

相關(guān)期刊論文 前8條

1 龔德華,季大璽,謝紅浪,徐斌,劉蕓,黎磊石,祁曉萍,許瑞吉;高低通量透析中患者血漿細(xì)胞因子及內(nèi)毒素水平的研究[J];中國(guó)危重病急救醫(yī)學(xué);2001年01期

2 田淑俠;劉春萍;封文媛;;高低通量血液透析膜清除溶質(zhì)能力的臨床對(duì)比[J];中國(guó)藥物經(jīng)濟(jì)學(xué);2013年S3期

3 唐瑞秀,馮婉貞;高通量和低通量透析器復(fù)用效果觀察[J];透析與人工器官;2005年02期

4 陸瑩;狄偉南;;高、低通量血液透析對(duì)尿毒癥病人透析質(zhì)量的比較[J];中國(guó)血液流變學(xué)雜志;2006年03期

5 栗明;蔣更如;;高低通量血液透析膜清除溶質(zhì)能力的比較[J];中國(guó)組織工程研究與臨床康復(fù);2007年31期

6 周紅衛(wèi);謝愷慶;廖松;伍民生;覃香芬;;前稀釋高容量聯(lián)機(jī)血液濾過(guò)與低通量血液透析清除效果的前瞻性交叉研究[J];實(shí)用醫(yī)學(xué)雜志;2006年17期

7 陶建瓴;孫陽(yáng);李雪梅;李航;王玉英;李學(xué)旺;;低通量聚砜膜進(jìn)行血液透析對(duì)患者血清炎癥因子、C反應(yīng)蛋白、脂蛋白(a)和β_2微球蛋白的影響[J];中國(guó)醫(yī)學(xué)科學(xué)院學(xué)報(bào);2009年03期

8 ;[J];;年期

相關(guān)會(huì)議論文 前1條

1 王質(zhì)剛;;透析膜吸附功能[A];血液凈化透析膜與透析液研究進(jìn)展及質(zhì)量控制學(xué)習(xí)班講義[C];2005年

相關(guān)碩士學(xué)位論文 前1條

1 王艷璇;低通量聚砜膜進(jìn)行血液透析對(duì)患者血清IL-1β、IL-6、C反應(yīng)蛋白、補(bǔ)體C_3、C_4及中性粒細(xì)胞、單核細(xì)胞、血小板的影響[D];中國(guó)醫(yī)科大學(xué);2010年

，

本文編號(hào)：1875524