本文選題：奇異變形桿菌 + 耐藥率��； 參考：《中國消毒學(xué)雜志》2017年10期

【摘要】：目的了解奇異變形桿菌的臨床分布與耐藥情況,為臨床合理用藥提供依據(jù)。方法通過細菌鑒定、藥敏試驗等方法,對上海市第五人民醫(yī)院2012—2015年臨床分離的奇異變形桿菌進行分析。結(jié)果共分離奇異變形桿菌226株,主要來源于尿液(45%)、痰液(22%)和膿液(16%)。2012-2015年奇異變形桿菌ESBLs陽性率分別為22.5%、43.5%、28.6%和51.7%,呈總體上升趨勢。產(chǎn)超廣譜β內(nèi)酰胺酶(ESBLs)菌株對β-內(nèi)酰胺類、氨基糖苷類、喹諾酮類和磺胺類抗菌藥物的耐藥率高于非產(chǎn)ESBLs菌株。奇異變形桿菌較為敏感的抗菌藥物為亞胺培南、美羅培南、頭孢哌酮/舒巴坦(2%),哌拉西林/他唑巴坦(2%),頭孢美唑(3%)。結(jié)論隨著ESBLs株檢出率上升,臨床分離的奇異變形桿菌對β-內(nèi)酰胺類、氨基糖苷類、喹諾酮類和磺胺類抗菌藥物的耐藥率也呈現(xiàn)上升,應(yīng)加強對奇異變形桿菌的耐藥監(jiān)控,科學(xué)合理用藥。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of Proteus mirabilis and to provide evidence for rational drug use. Methods Proteus mirabilis isolated from 2012 to 2015 in Shanghai Fifth people's Hospital was analyzed by bacteria identification and drug sensitivity test. Results A total of 226 strains of Proteus mirabilis were isolated. The positive rates of Proteus mirabilis ESBLs were 22.5% and 51.7%, respectively, in the period of 2012-2015. The positive rates of Proteus mirabilis were 43.528.6% and 51.7%, respectively, and the positive rates of Proteus mirabilis were 22.5% and 51.7%, respectively. The resistance rate of extended-spectrum 尾 -lactamase producing strains to 尾 -lactams, aminoglycosides, quinolones and sulfonamides was higher than that of non-producing ESBLs strains. The sensitive antimicrobial agents of Proteus mirabilis were imipenem, meropenem, cefoperazone / sulbactam, piperacillin / tazobactam and cefmetazolium. Conclusion with the increase of the detection rate of ESBLs strains, the resistance of Proteus mirabilis to 尾 -lactams, aminoglycosides, quinolones and sulfonamides also increased, so the resistance monitoring of Proteus mirabilis should be strengthened. Scientific and rational use of drugs.
【作者單位】： 上海市第五人民醫(yī)院;
【基金】：復(fù)旦大學(xué)附屬上海市第五人民醫(yī)院科研課題(2016WYQJ04)
【分類號】：R446.5

【相似文獻】

相關(guān)期刊論文 前10條

1 徐向東;馮志山;李仲興;;不產(chǎn)硫化氫的奇異變形桿菌引起傷口感染1例報告[J];張家口醫(yī)學(xué)院學(xué)報;1992年02期

2 夏佩瑩;;糞、尿中分離的奇異變形桿菌對泌尿系統(tǒng)的致病性[J];國外醫(yī)學(xué)(微生物學(xué)分冊);1987年02期

3 應(yīng)春妹;何澄;汪雅萍;葉楊芹;張灝e，

本文編號：1846038