本文關(guān)鍵詞：保婦康栓治療宮頸炎合并HPV感染的臨床研究，由筆耕文化傳播整理發(fā)布。

保婦康栓治療宮頸炎合并HPV感染的臨床研究

【摘要】 目的 探討保婦康栓治療宮頸炎合并人乳頭瘤病毒(HPV)感染的確切療效。方法 選取2008年1月至2010年1月在開(kāi)封市中醫(yī)院婦科門(mén)診確診的宮頸炎合并HPV感染≥2年患者作為觀察病例，按照隨機(jī)、對(duì)照的原則分為治療組和對(duì)照組，其中治療組76例，保婦康栓陰道用藥，對(duì)照組60例，干擾素栓陰道用藥，兩組均2周為1療程，均用藥3個(gè)療程，療程結(jié)束后2周內(nèi)復(fù)診，對(duì)兩組治療前后婦科檢查及雜交捕獲二代(HC Ⅱ)、液基細(xì)胞學(xué)(TCT)檢測(cè)結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果 兩組HPV(RLU/CO值)療效比較P=0.434＞0.05，兩組療效相當(dāng)；兩組宮頸炎(TCT積分+宮頸糜爛積分)療效比較P=0.045＜0.05，治療組療效優(yōu)于對(duì)照組。結(jié)論 保婦康栓療效確切，具有抗HPV感染、抗菌、消炎的作用，值得在臨床推廣應(yīng)用。

【Abstract】 Objective To study the exact clinical efficiency of Baofukang uppository in treating cervicitis combined with human papillomavirus (HPV) infection.Methods The patients sufferd from cervicitis with HPV infection persisted ≥2years,between January 2008 to January 2011 at TCM Hospital of Kaifeng City,were randomly divided into treatment group and control group,the treatment group included 76 patients were given Baofukang uppository,the control group included 60 patients were given Ganraosu uppository.Both group were treated for 2 weeks as a course,and every group was treated for 3 courses,2 weeks later after 3 courses,all the patients came back accepted gynecological examination,TCT and HC Ⅱ test,and the changes of gynecological examination,TCTand HC Ⅱ test before and after treaiment were observed and analyed respectively.Results The effect of HPV between treatment group had no significant difference(P=0.434＞0.05).As asignificant difference was demonstrated between the two groups in cervicitis index(TCT index and cervical erosion index)(P=0.434＞0.05),There was much better effect in test gongp than control group.Conclusion Baofukang uppository has anti-HPV infection,anti-Bacterial,anti-inflammatory efficacy,which exact clinical efficiency was suitable for clinical application.

【Key words】 cervicitis;human papillomavirus;chinese medicine;Baofukang uppository

宮頸炎是已婚婦女的常見(jiàn)病、多發(fā)病，合并人乳頭瘤病毒(human papillomavirus,簡(jiǎn)稱(chēng)HPV)感染成為宮頸癌發(fā)生的必要病因之一［1］，30歲以上持續(xù)性(≥2年)HPV感染的婦女是宮頸癌的高危人群［2］。目前，對(duì)HPV感染的治療，主要是西藥干擾素栓劑的局部使用，具有一定的臨床療效。

中成藥保婦康栓主要含冰片及莪術(shù)油等抗腫瘤細(xì)胞和抗病毒的成分，目前臨床廣泛用于宮頸炎、陰道炎的治療［3］。我們進(jìn)行此項(xiàng)研究的目的是驗(yàn)證保婦康栓陰道局部用藥的抗HPV確切療效，為臨床應(yīng)用保婦康栓治療宮頸HPV感染提供有力的證據(jù)。

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  本文關(guān)鍵詞：保婦康栓治療宮頸炎合并HPV感染的臨床研究，由筆耕文化傳播整理發(fā)布。