本文選題：骨腫瘤　切入點(diǎn)：轉(zhuǎn)運(yùn)常數(shù)　出處：《臨床放射學(xué)雜志》2017年08期

【摘要】：目的探討定量動(dòng)態(tài)增強(qiáng)(DCE)MRI對(duì)骨腫瘤良惡性的鑒別診斷價(jià)值。方法選取2014年7月至2016年2月河南省腫瘤醫(yī)院骨腫瘤患者61例(其中良性組21例,惡性組40例)并行DCE-MRI檢查,分別計(jì)算兩組患者的相關(guān)參數(shù):容量轉(zhuǎn)運(yùn)常數(shù)(K~(trans))、速率常數(shù)(K_(ep))、血管外細(xì)胞外間隙容積分?jǐn)?shù)(V_e)及1分鐘內(nèi)初始曲線下面積(iAUC),并進(jìn)行獨(dú)立樣本t檢驗(yàn)分析,隨后應(yīng)用受試者工作特征曲線(ROC)找出兩組的鑒別切點(diǎn),并計(jì)算有統(tǒng)計(jì)學(xué)差異的各指標(biāo)診斷惡性骨腫瘤的敏感度、特異度、準(zhǔn)確率、陽(yáng)性預(yù)測(cè)值、陰性預(yù)測(cè)值。結(jié)果 K~(trans)、K_(ep)、iAUC在良、惡性組間差異有統(tǒng)計(jì)學(xué)意義(P0.05),ROC曲線下面積(AUC)分別為0.802、0.802、0.693,K~(trans)、K_(ep)、iAUC的最佳診斷切點(diǎn)值分別為0.570(min~(-1))、2.467(min~(-1))、14.13,定量參數(shù)中K~(trans)0.570(min~(-1)),K_(ep)2.467(min~(-1)),iAUC14.13作為惡性骨腫瘤的診斷標(biāo)準(zhǔn),敏感度為92.5%、75.0%、80.0%,特異度為57.1%、71.4%、52.3%,準(zhǔn)確率80.3%、73.4%、70.5%,陽(yáng)性預(yù)測(cè)值80.4%、83.3%、76.2%,陰性預(yù)測(cè)值80.0%、60.0%、57.9%。V_e在良性組、惡性組間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論定量DCE-MRI可以用于骨腫瘤良惡性的鑒別診斷,其中K~(trans)、K_(ep)、iAUC為有鑒別價(jià)值的參數(shù)。
[Abstract]:Objective to evaluate the value of quantitative dynamic contrast enhanced Mr imaging (DCE-MRI) in differential diagnosis of benign and malignant bone tumors.Methods from July 2014 to February 2016, 61 patients with bone tumor (21 benign and 40 malignant) were examined by DCE-MRI.The relevant parameters of the two groups were calculated respectively: volume transport constant, rate constant, extracellular space volume fraction, and area under the initial curve within one minute.Then the discriminant point of the two groups was found by using the operating characteristic curve of the subjects, and the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the indexes with statistical difference in the diagnosis of malignant bone tumor were calculated.緇撴灉 K~(trans),K_(ep),iAUC鍦ㄨ壇,鎭舵，

本文編號(hào)：1714035