本文選題：原發(fā)性三叉神經(jīng)痛　切入點(diǎn)：靜息態(tài)　出處：《安徽醫(yī)科大學(xué)學(xué)報(bào)》2017年07期

【摘要】：目的利用功能性核磁共振成像(f MRI)技術(shù)評(píng)估三叉神經(jīng)痛患者處于靜息狀態(tài)下大腦自發(fā)性功能活動(dòng)變化。方法選擇原發(fā)性三叉神經(jīng)痛(ITN)患者組26例,健康對(duì)照組22例,受試者靜息態(tài)下進(jìn)行功能性核磁共振掃描。利用DPARSF軟件對(duì)圖像進(jìn)行處理,得到兩組人員的全腦平均低頻振幅率(mf ALFF)值。使用SPM12和SPSS 17.0軟件分析數(shù)據(jù)。結(jié)果兩組受試人員在年齡、受教育程度和男女比例上差異無統(tǒng)計(jì)學(xué)意義;ITN患者組部分腦區(qū)mf ALFF值明顯高于健康對(duì)照組,分別是:左側(cè)枕中回(BA18)、枕下回(BA19)、三角部額下回(BA47)、梭狀回(BA37)、小腦腳1區(qū)、距狀裂周圍皮層、中央旁回,右側(cè)背外側(cè)額上回(BA8),差異有統(tǒng)計(jì)學(xué)意義(P0.01)。結(jié)論 ITN患者多個(gè)相關(guān)腦區(qū)的mf ALFF值增高,提示患者在靜息狀態(tài)下,部分腦區(qū)的活動(dòng)改變可能與疼痛的調(diào)節(jié)或感覺的整合有關(guān)。
[Abstract]:Objective to evaluate the changes of spontaneous brain function in patients with trigeminal neuralgia by functional magnetic resonance imaging (fMRI) technique. Methods 26 patients with primary trigeminal neuralgia and 22 healthy controls were selected. The subjects were scanned by functional nuclear magnetic resonance (fMRI) under resting state. The mean low frequency amplitude rate of the whole brain was obtained by using DPARSF software. The data were analyzed by SPM12 and SPSS 17.0 software. There was no significant difference in education level and ratio between men and women. The values of MF ALFF in some brain regions in ITN group were significantly higher than those in healthy control group. They were: left middle occipital gyrus BA18, inferior occipital gyrus 19, triangle inferior frontal gyrus BA47, fusiform gyrus BA37, cerebellar foot 1. There was significant difference in the paracentral cortex, paracentral gyrus and right dorsolateral superior frontal gyrus (P 0.01). Conclusion the increase of MF ALFF in several related brain regions in ITN patients suggests that the patients are in resting state. Changes in activity in parts of the brain may be related to pain regulation or sensory integration.
【作者單位】： 安徽醫(yī)科大學(xué)口腔醫(yī)學(xué)院;安徽醫(yī)科大學(xué)第一附屬醫(yī)院疼痛科;安徽醫(yī)科大學(xué)第一附屬醫(yī)院放射科;安徽醫(yī)科大學(xué)基礎(chǔ)醫(yī)學(xué)院生理學(xué)教研室;
【基金】：國家自然科學(xué)基金(編號(hào):81271162) 國家級(jí)大學(xué)生創(chuàng)新創(chuàng)業(yè)訓(xùn)練計(jì)劃項(xiàng)目(編號(hào):201510366027)
【分類號(hào)】：R745.11
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本文編號(hào)：1690138