本文選題：急性心肌梗死　切入點(diǎn)：甲狀腺激素　出處：《中國(guó)老年學(xué)雜志》2017年22期 　論文類型：期刊論文

【摘要】：目的探討老年急性心肌梗死(AMI)患者甲狀腺激素及高敏C反應(yīng)蛋白(hs-CRP)水平變化及其檢測(cè)的臨床意義。方法 89例AMI患者作為AMI組,另選取健康體檢者80例作為對(duì)照組,比較兩組甲狀腺激素及hs-CRP水平;依據(jù)游離三碘甲狀腺原氨酸(FT3)三分位分為3組,比較3組性別、年齡、血糖、血脂、hs-CRP、心肌損傷標(biāo)志物、游離甲狀腺素(FT4)及促甲狀腺素(TSH)水平,并分析FT3、FT4、TSH及hs-CRP與其余指標(biāo)的相關(guān)性。結(jié)果 AMI組FT3水平顯著低于對(duì)照組,hs-CRP水平顯著高于對(duì)照組(P0.05);與高值組相比,中值組和低值組hs-CRP、肌酸激酶同工酶(CK-MB)和心肌肌鈣蛋白(c Tn)I水平均顯著降低,且低值組顯著低于中值組(P0.05);中值組和低值組TSH水平顯著高于高值組,且低值組顯著高于中值組(P0.05);FT3水平與hs-CRP、CK-MB、c Tn I水平呈顯著負(fù)相關(guān)(P0.05),FT4水平與c Tn I呈顯著負(fù)相關(guān)(P0.05),hs-CRP水平與總膽固醇(TC)、CK-MB、c Tn I水平呈顯著正相關(guān)(P0.05),TSH水平與上述指標(biāo)無相關(guān)性。結(jié)論老年AMI患者存在甲狀腺激素水平異常,且伴有hs-CRP水平升高,AMI患者FT3及hs-CRP可作為評(píng)估患者心肌損傷程度及預(yù)后的重要檢測(cè)指標(biāo)。
[Abstract]:Objective to investigate the changes of thyroid hormone and Gao Min C-reactive protein hs-CRP in elderly patients with acute myocardial infarction (AMI) and their clinical significance. Methods 89 patients with AMI as AMI group and 80 healthy persons as control group. The thyroid hormones and hs-CRP levels were compared between the two groups, and were divided into 3 groups according to free triiodothyronine FT3. The sex, age, blood glucose, blood lipid levels of hs-CRP, myocardial injury markers, free thyroxine FT4) and thyrotropin TSH were compared among the three groups. Results the level of FT3 in AMI group was significantly lower than that in control group (P 0.05), and was significantly higher than that in control group (P 0.05). The levels of hs-CRP, creatine kinase isoenzyme (CK-MBB) and cardiac troponin C Tn)I in the median group and the low value group were significantly lower than those in the median group and the low value group, and the levels of TSH in the median group and the low value group were significantly higher than those in the high value group. The low value group was significantly higher than the median group, the level of FT3 was significantly higher than that of the median group. There was a significant negative correlation between the level of hs-CRP, CK-MBN, c TnI, and the level of P0.05, FT4, and the level of c TnI. There was no significant positive correlation between the level of CRP and the level of total cholesterol, CK-MBc, TnI, and the level of TSH, which was not correlated with the above indexes. Conclusion there is abnormal thyroid hormone level in elderly patients with AMI. FT3 and hs-CRP can be used as an important index to evaluate the degree and prognosis of myocardial injury in patients with hs-CRP.
【作者單位】： 武漢市第三醫(yī)院光谷院區(qū)檢驗(yàn)科;湖北省腫瘤醫(yī)院核醫(yī)學(xué)科;
【分類號(hào)】：R446.1;R542.22

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