發(fā)布時間：2018-03-20 03:28

  本文選題：血液透析　切入點：心血管疾病　出處：《山西醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:通過觀察高通量血液透析對透析患者VEGF及ET-1水平的影響,以便更好地保護透析患者血管內(nèi)皮功能,從而使心血管疾病的風(fēng)險降低,為高通量血液透析的應(yīng)用提供有利證據(jù)。方法:選擇2015年9月至2016年10月于山西醫(yī)科大學(xué)第一醫(yī)院血凈中心行規(guī)律血液透析治療的患者70例,符合入選標準的有40例,分為A組與B組,A組:低通量血液透析;B組:高通量血液透析,每組20例患者,兩個組都每周3次規(guī)律進行血液透析治療,每次4個小時,治療6個月。測定兩個組在治療6個月前后血清中Scr、BUN、UA、VEGF及ET-1的水平。觀察兩個組在治療前與治療后各指標的變化情況。經(jīng)正態(tài)性檢驗,均數(shù)±標準差(x±S)描述符合正態(tài)分布的數(shù)據(jù)。配對t檢驗用于自身對照,LSD法用于組間兩兩的比較,卡方檢驗用于分類計數(shù)資料的組間比較,分析P0.05統(tǒng)計學(xué)差異有顯著性。結(jié)果:1.對兩組患者的年齡、性別、原發(fā)病進行比較,結(jié)果未見差別(P0.05);2.兩組患者血Scr、BUN、UA、VEGF及ET-1在治療前無差別(P0.05);3.治療6個月后,A、B組血清Scr、BUN、UA、VEGF、ET-1均比6個月前有改變,具有統(tǒng)計學(xué)差異(P0.05);4.治療6個,A、B組的血清Scr、BUN、UA均降低,且兩組6個月前后差值無顯著差別(P0.05);5.治療6個月后,與A組比較,B組可明顯降低血清中VEGF及ET-1水平,兩者具有顯著差別(P0.01)。結(jié)論:在清除血清Scr、BUN、UA等方面,高通量血液透析與低通量血液透析有相同的優(yōu)勢,但高通量血液透析可以明顯降低血清VEGF及ET-1的水平,從而有助于改善血管內(nèi)皮功能,減少心血管疾病,延長患者壽命。
[Abstract]:Objective: to observe the effect of high flux hemodialysis on the levels of VEGF and ET-1 in dialysis patients in order to protect vascular endothelial function and reduce the risk of cardiovascular disease. Methods: from September 2015 to October 2016, 70 patients who were treated with regular hemodialysis in Xuejing Center, first Hospital of Shanxi Medical University, met the inclusion criteria. The patients were divided into two groups: group A and group B: low flux hemodialysis group B: high flux hemodialysis with 20 patients in each group. The two groups received regular hemodialysis three times a week for 4 hours. After 6 months of treatment, the serum levels of Scr-BUNU UAA and ET-1 in the two groups were measured before and after 6 months of treatment. The changes of the indexes before and after treatment in the two groups were observed. Mean 鹵standard deviation x 鹵S) is used to describe data consistent with normal distribution. Paired t test is used for comparison between two groups by self-control LSD method, and chi-square test is used for comparison of classified counting data. Results: 1. The age, sex and primary disease of the two groups were compared. Results there was no significant difference between the two groups (P < 0.05). There was no difference between the two groups before treatment. After 6 months of treatment, the serum levels of Scr-BUNU UAV VEGFFN-1 in group A were all changed compared with those before 6 months, and there was statistical difference between the two groups (P 0.05), and the serum levels of Scr-BUNA in group A were lower than those in group A (P < 0.05), and the levels of ET-1 in group A were significantly lower than those in group A (P < 0.05) after 6 months of treatment. There was no significant difference in the difference between the two groups before and after 6 months. After 6 months of treatment, the serum levels of VEGF and ET-1 in group B were significantly lower than those in group A. High flux hemodialysis has the same advantages as low flux hemodialysis, but high flux hemodialysis can obviously reduce the levels of serum VEGF and ET-1, thus help to improve vascular endothelial function, reduce cardiovascular disease and prolong the life span of patients.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R692.5

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