本文選題：海馬　切入點(diǎn)：磁共振成像　出處：《中國(guó)醫(yī)學(xué)影像學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：目的通過比較Freesurfer和基于體素的形態(tài)學(xué)測(cè)量軟件(VBM8)分別與手動(dòng)測(cè)量海馬體積的相關(guān)性和一致性,探討能夠代替手動(dòng)分割海馬體積及腦部結(jié)構(gòu)的自動(dòng)測(cè)量方法。資料與方法分別收集青年(20~40歲)受試者67例、老年(60~80歲)受試者75例,全腦MRI掃描后分別使用手動(dòng)分割、導(dǎo)入Freesurfer和VBM8中獲得海馬體積,應(yīng)用Pearson相關(guān)分析和組內(nèi)相關(guān)系數(shù)(ICC)分別統(tǒng)計(jì)Freesurfer和VBM與手動(dòng)測(cè)量的相關(guān)性,用Bland-Altman散點(diǎn)圖分析一致性。結(jié)果 Freesurfer、VBM與手動(dòng)測(cè)量的相關(guān)性較高,青年組Freesurfer和VBM左右兩側(cè)r值分別為0.633、0.679和0.666、0.703,老年組r值分別為0.627、0.765和0.663、0.708;而ICC有明顯差異,Freesurfer測(cè)得青年組(ICC=0.377、0.502)老年組(ICC=0.307、0.459);但總體上ICC_(VBM)ICC_(Freesurfer),右側(cè)海馬體積左側(cè)。由Bland-Altman散點(diǎn)圖顯示VBM與手動(dòng)測(cè)量的一致性高于Freesurfer。結(jié)論 Freesurfer可局限性地用于青年受試海馬體積測(cè)量;而VBM較Freesurfer可更準(zhǔn)確地代替手動(dòng)分割以測(cè)量成人海馬體積,可應(yīng)用于海馬相關(guān)臨床疾病或?qū)嶒?yàn)所需要的體積測(cè)量。
[Abstract]:Objective to compare the correlation and consistency between Freesurfer and VBM8, a morphometric software based on voxel, and to measure hippocampal volume manually. To explore an automatic measurement method that can replace manual segmentation of hippocampal volume and brain structure. The data and methods were collected from 67 young subjects aged 20 to 40 years and 75 elderly subjects aged 6080 years. The whole brain was divided into two groups by manual segmentation after MRI scanning. The hippocampal volume was obtained by introducing Freesurfer and VBM8. The correlation of Freesurfer and VBM with manual measurement was analyzed by Pearson correlation analysis and intragroup correlation coefficient, and the consistency was analyzed by Bland-Altman scatter plot. Results the correlation between Pearson correlation and manual measurement was higher. The r values of left and right sides of Freesurfer and VBM in the young group were 0.633n 0.679 and 0.666U 0.703, respectively, and the values of the aged group were 0.62770.65 and 0.663U 0.708, respectively, while the ICC values were 0.3770.502.There was a significant difference in ICC between the young group and the young group (0.3070.502), but on the whole, the ICCV-BMICC+ / Freesurfera and the left side of the right hippocampus. The VBM and the left side of the right hippocampus were shown by the Bland-Altman scatter plot. Conclusion Freesurfer can be used to measure hippocampal volume in young people. VBM can replace manual segmentation to measure adult hippocampal volume more accurately than Freesurfer. It can be used to measure the volume of hippocampal clinical diseases or experiments.
【作者單位】： 重慶醫(yī)科大學(xué)解剖學(xué)教研室;重慶醫(yī)科大學(xué)附屬第一醫(yī)院放射科;
【分類號(hào)】：R445.2;R741

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