本文選題：宮頸癌　切入點：擴散加權(quán)成像　出處：《臨床放射學雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的通過分析正常宮頸及宮頸癌組織的多b值擴散加權(quán)成像(DWI)及動態(tài)增強(DCE-MRI)掃描的特點,探討其對宮頸癌分期及監(jiān)測宮頸癌放化療療效的價值。方法搜集經(jīng)活檢證實的中晚期宮頸癌患者40例(腺癌12例,鱗癌28例),進行常規(guī)MRI、多b值DWI和動態(tài)增強掃描。使用單因素方差分析法對比宮頸癌放化療前后的多組不同b值時測得的表觀擴散系數(shù)(ADC)值;采用卡方檢驗的Fisher確切概率法對比宮頸癌放化療前后動態(tài)增強時間-信號強度曲線(TIC)類型,并對比宮頸癌與正常宮頸三層結(jié)構(gòu)的TIC類型。結(jié)果 12例腺癌和28例鱗癌的多b值平均ADC值差異具有統(tǒng)計學意義(各組P0.05)。40例宮頸癌患者的TIC分布Ⅰ型2例,Ⅱ型31例,Ⅲ型7例;正常宮頸黏膜Ⅰ型33例,Ⅱ型7例;正常宮頸結(jié)合帶Ⅰ型31例,Ⅱ型9例,正常宮頸肌層Ⅰ型35例,Ⅱ型5例。宮頸癌與正常宮頸組織的TIC類型分布差異具有統(tǒng)計學意義(χ~2=83.708,P0.05);常規(guī)MRI聯(lián)合多b值DWI和動態(tài)增強掃描對宮頸癌的診斷分期與臨床分期的符合率為97.5%;宮頸癌放化療前后的ADC值差異具有統(tǒng)計學意義(t=30.315,P0.05);宮頸癌治療前后的TIC分布差異有統(tǒng)計學意義(χ~2=52.051,P0.05)。結(jié)論多b值DWI聯(lián)合動態(tài)增強檢查可以提高宮頸癌的分期準確率,并對監(jiān)測宮頸癌放化療療效有重要價值。
[Abstract]:Objective to analyze the features of DWI and DCE-MRI in normal cervix and cervical carcinoma. To evaluate its value in staging cervical cancer and monitoring the curative effect of radiotherapy and chemotherapy on cervical cancer. Methods 40 patients with advanced cervical cancer (adenocarcinoma 12 cases) confirmed by biopsy were collected. Twenty-eight patients with squamous cell carcinoma were examined with conventional MRI, multi-b DWI and dynamic contrast-enhanced scan. The apparent diffusion coefficient (ADCC) of cervical cancer before and after radiotherapy and chemotherapy was compared by univariate variance analysis. The exact probability method of Fisher based on chi-square test was used to compare the type of dynamic enhancement time-signal intensity curve before and after radiotherapy and chemotherapy for cervical cancer. Results there were significant differences in the mean ADC values of multiple b values between 12 cases of adenocarcinoma and 28 cases of squamous cell carcinoma (P0.050.40 cases of cervical cancer, 2 cases of type 鈪，

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