發(fā)布時間：2018-03-06 03:22

  本文選題：磁共振成像　切入點：高強度聚焦超聲　出處：《吉林大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:通過研究子宮肌瘤動態(tài)增強磁共振成像(Dynamic Contrast Enhanced MRI,DCE-MRI)定量參數(shù)與治療效果的相關(guān)性,探討定量參數(shù)對子宮肌瘤高強度聚焦超聲(High Intensity Focused Ultrasound,HIFU)療效即時評價的應(yīng)用價值。材料與方法:根據(jù)納入和排除標(biāo)準(zhǔn)收集子宮肌瘤HIFU治療的13個病例,應(yīng)用Philips Achieva 3.0T磁共振,在治療前1天內(nèi)、治療后1天內(nèi)行MRI平掃及DCE-MRI檢查。應(yīng)用Omni-Kinetics(GE Healthcare)軟件依據(jù)雙室Tofts模型得到各定量參數(shù)值。根據(jù)治療后DCE-MRI的影像表現(xiàn)分為完全消融組和不完全消融組。先采用Mann-Whitney U檢驗,然后(1)采用配對樣本t檢驗比較各參數(shù)治療前后的差異;(2)應(yīng)用方差分析比較兩組間各參數(shù)的差異;(3)應(yīng)用Spearman秩相關(guān)分析研究定量參數(shù)與不同分組間的關(guān)聯(lián)。結(jié)果:(1)HIFU治療后,Ktrans、Kep、Ve均明顯減低,差異具有統(tǒng)計學(xué)意義(p0.05),Vp變化不明顯。(2)除Vp_(治療前-治療后)外,治療前所有定量參數(shù)與治療后的定量參數(shù)差值(即治療前-治療后)與分組無相關(guān)性(P0.05)。(3)兩組中Ktrans_(治療后)、Ve_(治療后)及Ktrans_(變化率)、Ve_(變化率)與分組情況呈相關(guān)性,其中Ktrans_(治療后)、Ve_(治療后)與分組呈正相關(guān),相關(guān)系數(shù)分別為r=0.713和0.757;Ktrans_(變化率)、Ve_(變化率)與分組呈負(fù)相關(guān),且相關(guān)性更顯著,相關(guān)系數(shù)均為r=-0.802。結(jié)論:子宮肌瘤HIFU術(shù)后的即時療效評價可以應(yīng)用DCE-MRI定量參數(shù),定量參數(shù)值對臨床預(yù)后的指導(dǎo)具有參考價值。
[Abstract]:Objective: through the study of enhanced magnetic resonance imaging of uterine leiomyoma (Dynamic Contrast Enhanced dynamic MRI, DCE-MRI) correlation between quantitative parameters and treatment effect, explore the quantitative parameters of Hysteromyoma with high intensity focused ultrasound (High Intensity, Focused Ultrasound, HIFU) application effect of immediate evaluation. Materials and methods: according to inclusion and exclusion criteria 13 cases collection of HIFU in the treatment of uterine fibroids, the application of Philips Achieva 3.0T MRI, in 1 days before treatment, after treatment 1 days after the MRI scan and DCE-MRI examination. The application of Omni-Kinetics (GE Healthcare) software based on double chamber Tofts model get the quantitative parameter values. According to DCE-MRI findings after treatment divided into complete ablation group and no complete ablation group. Using Mann-Whitney U test, and (1) the difference before and after the paired sample t test to compare the parameters of therapy; (2) analyzed by variance analysis 涓ょ粍闂村悇鍙傛暟鐨勫樊寮，

本文編號：1573130