本文選題：灌注加權(quán)成像　切入點(diǎn)：肝纖維化　出處：《放射學(xué)實(shí)踐》2017年11期 　論文類型：期刊論文

【摘要】：目的:分析大鼠肝纖維化、肝硬化磁共振灌注成像(MR-PWI)參數(shù)特征,評(píng)價(jià)PWI對(duì)肝纖維化、肝硬化病理分級(jí)的價(jià)值。方法:清潔級(jí)SD大鼠100只,體重約150~200g,雄性。將大鼠隨機(jī)分為2組,對(duì)照組(n=16),實(shí)驗(yàn)組(n=84);實(shí)驗(yàn)組腹腔定點(diǎn)注射硫代乙酰胺(TAA),對(duì)照組同期腹腔注射相同劑量生理鹽水。建模成功后實(shí)驗(yàn)組和對(duì)照組分批次進(jìn)行肝臟常規(guī)磁共振掃描及PWI掃描。依據(jù)病理結(jié)果將肝臟損傷分為5組:肝纖維化0期(對(duì)照組)、肝纖維化Ⅰ期(S1),肝纖維化Ⅱ期(S2),肝纖維化Ⅲ期(S3),肝硬化結(jié)節(jié)期(S4),然后分析灌注參數(shù)與病理分級(jí)的相關(guān)性。結(jié)果:共69只大鼠(實(shí)驗(yàn)組57只,對(duì)照組12只)成功獲取PWI圖像并進(jìn)行灌注參數(shù)測(cè)量,成功率69%(69/100)。各期門(mén)靜脈諸灌注參數(shù)之間差異有統(tǒng)計(jì)學(xué)意義(P0.05),各期肝實(shí)質(zhì)諸灌注參數(shù)之間差異有統(tǒng)計(jì)學(xué)意義(P0.001)。門(mén)靜脈TTP及WOR與肝纖維化分級(jí)之間存在相關(guān)性(r=0.420、-0.464,P0.001)。肝實(shí)質(zhì)TTP及WIR與肝纖維化分級(jí)之間存在相關(guān)性(r=0.424、-0.488,P0.001)。結(jié)論:MR-PWI參數(shù)與大鼠肝纖維化、肝硬化的分級(jí)有一定相關(guān)性。MR-PWI對(duì)評(píng)價(jià)肝纖維化分期具有一定的臨床價(jià)值。
[Abstract]:Objective: to analyze the characteristics of Mr perfusion imaging (MR-PWI) parameters of hepatic fibrosis and cirrhosis in rats and to evaluate the value of PWI in hepatic fibrosis and pathological grading of cirrhosis. Methods: 100 SD rats of clean grade, weighing about 150 ~ 200g, were randomly divided into two groups. The control group (n = 16) and the experimental group (n = 84) were given intraperitoneal injection of acetamide thioacetamide (TAA) and the same dose of normal saline at the same time. After the model was successfully established, the rats in the experimental group and the control group were scanned by routine magnetic resonance imaging (MRI) and PWI scan in different batches. According to the pathological results, liver injury was divided into 5 groups: hepatic fibrosis stage 0 (control group), hepatic fibrosis stage 鈪，

本文編號(hào)：1571752