本文選題：肝病　切入點：真菌　出處：《中華醫(yī)院感染學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的觀察肝病住院患者真菌感染情況,并分析其藥敏結(jié)果。方法選擇醫(yī)院2011年1月-2015年12月收集標(biāo)本中培養(yǎng)出真菌1 000例住院肝病患者進行研究,收集患者的真菌培養(yǎng)結(jié)果及藥敏試驗結(jié)果。結(jié)果 1000例肝病患者分離出1410株真菌中,酵母樣真菌1189株占84.3%,絲狀真菌221株占15.7%;1189株酵母樣真菌中,痰及咽拭子感染737株占62.0%,胸腹水和尿感染分別為146株占12.3%和140株占11.8%;221株絲狀真菌中,痰及咽拭子感染202株占91.4%。酵母樣真菌中,對氟康唑、伊曲康唑、兩性霉素和伏立康唑的耐藥率分別為12.1%、2.3%、0.3%和1.9%;絲狀真菌中,對氟康唑、良性霉素、伊曲康唑和伏立康唑的耐藥率分別為93.7%、16.7%、5.9%和4.5%;酵母樣真菌對氟康唑、伊曲康唑、良性霉素和伏立康唑的耐藥率均低于絲狀真菌(P0.05)。結(jié)論住院肝病患者以酵母樣真菌感染為主,白假絲酵母菌的感染率最高,且對抗真菌藥的耐藥率均低于熱帶假絲酵母菌。
[Abstract]:Objective to observe the fungal infection in inpatients with liver disease and to analyze its drug sensitivity. Methods from January 2011 to December 2015, 1 000 cases of fungal infection were collected from hospital and studied. Results of the 1410 fungi isolated from 1000 patients with liver disease, 1189 were yeast like fungi, and 221 filamentous fungi accounted for 15.7 and 1189 yeast-like fungi, respectively. 737 strains of sputum and pharynx swabs accounted for 62.0%, 12.3% strains of hydrothorax and 140 strains of urine infection accounted for 11.8% of filamentous fungi, and 202 strains of sputum and pharynx swabs infection accounted for 91.4%. In yeast fungi, p-fluconazole and itraconazole were found. The resistance rates of amphotericin to fluconazole, benign mycin, itraconazole and voriconazole in filamentous fungi were 93. 7% and 4. 5%, respectively. The resistance rates of yeast-like fungi to fluconazole, itraconazole, and entraconazole were 93. 7% and 4. 5%, respectively. The drug resistance rates of benign mycin and voleconazole were lower than that of P0.050.Conclusion the infection rate of Saccharomyces albicans is the highest and the resistance rate of antifungal agents is lower than that of Candida tropicalis.
【作者單位】： 浙江省麗水市中醫(yī)院檢驗科;麗水市疾病預(yù)防控制中心;
【基金】：浙江省醫(yī)藥衛(wèi)生科技計劃基金資助項目(2014KBY318)
【分類號】：R575;R446.5

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相關(guān)期刊論文 前8條

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本文編號：1570404