本文關(guān)鍵詞： VX腫瘤 肌肉 磁共振成像 彌散加權(quán)成像　出處：《廣東醫(yī)學(xué)》2017年09期 　論文類型：期刊論文

【摘要】：目的評(píng)價(jià)不同b值條件下所得VX2腫瘤和肌肉組織的表觀彌散系數(shù)(ADC)值的差異,并比較腫瘤和肌肉組織間各種ADC值的差別,以探討可鑒別兩者的有效ADC值計(jì)算方法。方法在15只新西蘭兔大腿接種VX2腫瘤,3周后對(duì)其行動(dòng)態(tài)對(duì)比劑增強(qiáng)磁共振成像(DCE-MRI)和多b值彌散加權(quán)成像(DWI);由b=0、50、100 s/mm~2的DWI生成ADC_(low);由b=400、600、800 s/mm~2的DWI生成ADC_(high)。根據(jù)增強(qiáng)早期DCE-MRI在ADC_(low)和ADC_(high)圖選取感興趣區(qū)測量VX2腫瘤組織和肌肉組織的ADC_(low)和ADC_(high)值。比較VX2腫瘤組織及肌肉的ADC_(low)與ADC_(high)的差別;同時(shí)分析VX2腫瘤組織與肌肉組織之間ADC_(low)及ADC_(high)的差異,并比較其ROC曲線下面積。結(jié)果 VX2腫瘤組織的ADC_(low)及ADC_(high)分別為(1.378±0.203)×10~(-3)mm~2/s、(1.089±0.098)×10~(-3)mm~2/s,差異有統(tǒng)計(jì)學(xué)意義(P0.001);肌肉的ADC_(low)及ADC_(high)分別為(1.684±0.059)×10~(-3)mm~2/s、(1.538±0.053)×10~(-3)mm~2/s,差異有統(tǒng)計(jì)學(xué)意義(P0.001)。VX2腫瘤組織與肌肉之間的ADC_(low)及ADC_(high)的差異也均有統(tǒng)計(jì)學(xué)意義(P0.001);ADC_(high)與ADC_(low)的ROC曲線下面積分別為1.000和0.903,差異有統(tǒng)計(jì)學(xué)意義(P=0.023)。結(jié)論利用低b值DWI所得ADC值受灌注效應(yīng)的影響大,存活組織的ADC_(low)高于ADC_(high);對(duì)于細(xì)胞排列密集的軟組織腫瘤,ADC_(high)區(qū)別腫瘤和肌肉兩種組織的效能較高。
[Abstract]:Objective to evaluate the difference of apparent diffusion coefficient (ADC) of VX2 tumor and muscle tissue under different b values, and to compare the differences of ADC values between tumor and muscle tissue. To investigate the effective ADC value calculation method for differentiating the two. Methods dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and multi-b diffusion-weighted imaging (DWII) were performed in 15 New Zealand rabbits with VX2 tumor inoculated in their thighs for 3 weeks. The DWI of B400 / 600 / 800 s / mm / mm / 2 is used to produce high ADCS. According to the enhanced early DCE-MRI (ADCS) and ADCS / DCE-MRI (high) charts, the values of ADCS and ADCS in the area of interest are selected. The difference between the VX2 tumor tissue and the muscle is compared with that of the ADCS / ADCS. At the same time, the difference between VX2 tumor tissue and muscle tissue was analyzed. The area under the ROC curve was compared. Results the ADCStup level of VX2 tumor tissue was 1.378 鹵0.203) 脳 10 ~ (-3) mm ~ (-2) / s, the difference was statistically significant (P = 0.001). The difference was significant (P0.001). The difference between the two groups were as follows: (1. 684 鹵0. 059) 脳 10 ~ (10) 鹵0. 038 鹵0. 053) 脳 10 ~ (3) mm ~ (-2) s. The difference was statistically significant (P = 0. 001. VX2) and the difference between the two groups was significant (P = 0. 001. VX2). The area under the ROC curve was 1.000 and 0.903, respectively, and the difference was statistically significant. Conclusion the ADC value obtained by using DWI with low b value is greatly affected by the perfusion effect. The ADCC levels of surviving tissues were higher than those of ADCC cells, and the efficiency of differentiating tumor from muscle tissue was higher for soft tissue tumors with dense cell arrangement.
【作者單位】： 中山大學(xué)附屬第一醫(yī)院醫(yī)學(xué)影像科;中山市中醫(yī)院放射科;
【基金】：廣東省科技計(jì)劃項(xiàng)目(編號(hào):2012B031800071)
【分類號(hào)】：R445.2;R738
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本文編號(hào)：1525769