本文關(guān)鍵詞： 近紅外光譜 接觸壓力 光學(xué)參數(shù) 漫反射　出處：《光譜學(xué)與光譜分析》2017年10期 　論文類型：期刊論文

【摘要】：人體成分無創(chuàng)光譜檢測過程中,測量條件特別是探頭壓力造成的組織形變在一定程度上影響光譜測量結(jié)果。利用物理模型與仿真方法,定量分析了探頭接觸壓力作用下皮膚組織應(yīng)變,及光學(xué)參數(shù)與漫反射光譜變化。首先,在多層皮膚組織物理復(fù)合模型基礎(chǔ)上,結(jié)合生物組織固液兩相組成特性,定量分析了壓力作用下各層皮膚組織形變大小以及成分變化。該模型將皮膚力學(xué)模型簡化為固態(tài)彈性結(jié)構(gòu)及包含于其中的牛頓流體,利用有限元方法,分別模擬不同壓力作用下多層皮膚組織應(yīng)變大小及時間特性,并根據(jù)各層組織體積及水含量變化,定量計(jì)算其散射系數(shù)及吸收系數(shù)改變。然后,利用Monte Carlo方法模擬壓力作用前后光在組織中傳輸過程,定量分析了探頭壓力對漫反射光譜中所包含人體成分檢測有效信息的影響。實(shí)驗(yàn)結(jié)果表明,在光纖探頭接觸壓力作用下,人體皮膚組織中真皮層厚度變小,自由水體積減小,引起散射特性及光子傳輸路徑改變,使得漫反射光譜中所包含的有效光譜信息下降。該研究結(jié)果為優(yōu)化人體漫反射光譜測量策略,提高測量準(zhǔn)確性以及重復(fù)性提供了參考。
[Abstract]:In the process of noninvasive spectral measurement of human components, the measurement conditions, especially the tissue deformation caused by probe pressure, affect the results of spectral measurement to some extent. The physical model and simulation method are used. Quantitative analysis of skin tissue strain, optical parameters and diffuse reflectance spectrum changes under the contact pressure of probe. Firstly, based on the multi-layer skin tissue physical composite model, combined with biological tissue solid-liquid two-phase composition characteristics. Quantitative analysis of skin tissue deformation and composition changes under pressure. The skin mechanics model is simplified as solid elastic structure and Newtonian fluid contained in it, and finite element method is used. The strain and time characteristics of multi-layer skin under different pressures were simulated, and the scattering coefficient and absorption coefficient were calculated quantitatively according to the changes of tissue volume and water content in each layer. Monte Carlo method was used to simulate the propagation of light in tissues before and after pressure. The effect of probe pressure on the effective information of human body component detection contained in diffuse reflectance spectrum was quantitatively analyzed. The experimental results showed that the thickness of dermis in human skin tissue decreased under the contact pressure of optical fiber probe. The decrease of free water volume leads to the change of scattering characteristics and photon transmission path, which results in the decrease of the effective spectral information contained in diffuse reflectance spectroscopy. The results of this study are to optimize the measurement strategy of human diffuse reflectance spectrum. The accuracy and repeatability of measurement are improved.
【作者單位】： 天津大學(xué)精密測試技術(shù)及儀器國家重點(diǎn)實(shí)驗(yàn)室;天津大學(xué)精密儀器與光電子工程學(xué)院;
【基金】：國家自然科學(xué)基金項(xiàng)目(81401454,81471698,81671727) 中國博士后科學(xué)基金項(xiàng)目(2013M541174) 中國博士后國際交流計(jì)劃(20140066) 天津市應(yīng)用基礎(chǔ)與前沿技術(shù)研究計(jì)劃(16JCZDJC31200) 國家(863)高技術(shù)研究發(fā)展計(jì)劃(012AA022602)資助
【分類號】：O657.33;R443
【正文快照】： 引　言　　人體成分無創(chuàng)檢測研究中,漫反射光譜方法具有無創(chuàng)傷、測量方便、可應(yīng)用于多成分體系等優(yōu)點(diǎn),在生物光學(xué)研究以及臨床醫(yī)學(xué)中得到廣泛應(yīng)用[1-3]。實(shí)際應(yīng)用中,漫反射光譜檢測系統(tǒng)常采用光纖與待測組織直接接觸的測量方式,光纖探頭以一定壓力作用于皮膚組織,來消除運(yùn)動偽，

本文編號：1451540