本文關(guān)鍵詞：替加環(huán)素對(duì)多藥耐藥鮑氏不動(dòng)桿菌微生物學(xué)清除率與治療效果的分析　出處：《中華醫(yī)院感染學(xué)雜志》2017年11期 　論文類型：期刊論文

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【摘要】：目的觀察替加環(huán)素治療多藥耐藥鮑氏不動(dòng)桿菌感染的效果,探討其在多藥耐藥鮑氏不動(dòng)桿菌治療中的價(jià)值。方法選取2014年9月-2015年9月在醫(yī)院接受替加環(huán)素聯(lián)合頭孢哌酮/舒巴坦治療的59例多藥耐藥鮑氏不動(dòng)桿菌肺炎患者為觀察組,僅接受頭孢哌酮/舒巴坦治療的63例患者為對(duì)照組,組間基礎(chǔ)資料(性別、體重、APACHEⅡ評(píng)分等)相比無顯著性差異,分析兩組患者治療前后血清炎性指標(biāo)的變化、臨床療效及病原菌清除效果。結(jié)果治療前兩組患者血清白細(xì)胞(WBC)、C-反應(yīng)蛋白(CRP)、一氧化氮(NO)、降鈣素原(PCT)表達(dá)量差異無統(tǒng)計(jì)學(xué)意義,治療后3d、7d時(shí),觀察組患者血清WBC、CRP、NO、PCT均顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療總有效率觀察組為79.66%高于對(duì)照組57.14%,差異有統(tǒng)計(jì)學(xué)意義(P0.05)、微生物學(xué)完全清除率觀察組明顯高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論替加環(huán)素能夠明顯降低多藥耐藥鮑氏不動(dòng)桿菌肺炎患者炎癥反應(yīng)程度,且有較高的病原菌清除效果,是多藥耐藥鮑氏不動(dòng)桿菌肺炎較為理想的抗菌藥物。
[Abstract]:Objective to observe the efficacy of tegicycline in the treatment of multidrug resistant Acinetobacter baumannii infection. To explore its value in the treatment of multidrug resistant Acinetobacter baumannii methods 59 cases of multidrug resistant abalone treated with tegacycline combined with cefoperazone / sulbactam from September 2014 to September 2015 were selected. Patients with Acinetobacter pneumoniae were treated as observation group. There was no significant difference in basic data (sex, body weight, Apache 鈪，

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