本文關(guān)鍵詞：一種基于生物準(zhǔn)則的IMRT方案優(yōu)化方法　出處：《計(jì)算機(jī)應(yīng)用研究》2017年05期 　論文類型：期刊論文

  更多相關(guān)文章： 調(diào)強(qiáng)放射治療 生物準(zhǔn)則 L-BFGS-B 腫瘤控制率 正常組織并發(fā)癥概率

【摘要】：針對調(diào)強(qiáng)放射治療方案優(yōu)化中,物理準(zhǔn)則無法準(zhǔn)確描述生物組織在非均勻劑量分布下的生物反應(yīng)的問題,提出了基于生物準(zhǔn)則的方案優(yōu)化方法。首先根據(jù)病人各組織的劑量約束條件,建立基于生物準(zhǔn)則的方案優(yōu)化目標(biāo)函數(shù);然后采用L-BFGS-B算法求解方案優(yōu)化問題。實(shí)驗(yàn)結(jié)果表明,在保證靶區(qū)劑量覆蓋率的同時,相較于基于物理準(zhǔn)則的方案優(yōu)化方法,該方案優(yōu)化后的危及器官并發(fā)癥概率下降6.86%;相較于采用L-BFGS算法進(jìn)行方案優(yōu)化,該方案優(yōu)化后的危及器官并發(fā)癥概率下降1.30%。分析實(shí)驗(yàn)結(jié)果可得,將生物因子引入方案優(yōu)化,能夠更精確地反映組織的生物效應(yīng);采用L-BFGS-B算法能夠快速、精確地求解方案優(yōu)化問題。
[Abstract]:In the optimization of intensity modulated radiotherapy (IMRT) regimen, the physical criteria can not accurately describe the biological reaction of biological tissues under non-uniform dose distribution. In this paper, a scheme optimization method based on biological criteria is proposed. Firstly, according to the dose constraint conditions of each patient's tissues, the objective function of program optimization based on biological criteria is established. Then the L-BFGS-B algorithm is used to solve the optimization problem. The experimental results show that the target dose coverage is guaranteed, and the scheme optimization method based on physical criterion is compared. The risk of organ complications after optimization was decreased by 6.86%. Compared with the L-BFGS algorithm, the probability of organ complications decreased by 1.30%. The experimental results were analyzed and the biological factors were introduced into the optimization scheme. Can more accurately reflect the biological effects of tissue; Using L-BFGS-B algorithm can solve the optimization problem quickly and accurately.
【作者單位】： 中北大學(xué)電子測試技術(shù)國家重點(diǎn)實(shí)驗(yàn)室;中北大學(xué)儀器科學(xué)與動態(tài)測試教育部重點(diǎn)實(shí)驗(yàn)室;東南大學(xué)影像科學(xué)與技術(shù)實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(61271357) 山西省自然科學(xué)基金資助項(xiàng)目(2015011046) 中北大學(xué)2013年�？茖W(xué)基金計(jì)劃資助項(xiàng)目
【分類號】：R730.55
【正文快照】： 0引言調(diào)強(qiáng)放射治療[1](intensity modulated radiation therapy,IM-RT)方案優(yōu)化通過調(diào)整照射野的參數(shù),使高劑量區(qū)的形狀與靶區(qū)形狀達(dá)到基本一致,同時盡可能地減少靶區(qū)周圍的危及器官(organ at risk,OAR)及正常組織所接受的放射劑量,從而達(dá)到提高腫瘤放射治療精確度及降低正常，

本文編號：1390144