發(fā)布時(shí)間：2017-12-28 05:37

  本文關(guān)鍵詞：連續(xù)性血液凈化對(duì)SAP患者RAAS及炎癥因子的影響　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年04期 　論文類型：期刊論文

  更多相關(guān)文章： 連續(xù)性血液凈化 重癥急性胰腺炎 腎素-血管緊張素-醛固酮系統(tǒng) 炎癥因子

【摘要】：目的探討連續(xù)性血液凈化對(duì)重癥急性胰腺炎(SAP)患者腎素-血管緊張素-醛固酮系統(tǒng)(RAAS)及炎癥因子的影響。方法選取在該院住院治療的重癥急性胰腺炎患者64例,隨機(jī)分為治療組和對(duì)照組。治療組在接受基礎(chǔ)治療的同時(shí)接受連續(xù)性血液凈化治療,對(duì)照組接受基礎(chǔ)治療,比較兩組患者主要癥狀、指標(biāo)恢復(fù)正常時(shí)間及治療有效率的差異。比較兩組患者治療前和治療后1、3和7 d時(shí)各RAAS指標(biāo)和各炎癥因子的差異。結(jié)果治療組患者治療后腹痛、惡心、C反應(yīng)蛋白(CRP)、血清淀粉酶(AMS)恢復(fù)正常時(shí)間均低于對(duì)照組,且差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療組總的有效率(31例,91.18%)高于對(duì)照組(21例,70.0%),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組在治療后各RAAS指標(biāo)與治療前比較均降低,治療組在治療后1和3 d時(shí)的血管緊張素Ⅰ、血管緊張素Ⅱ、腎素、醛固酮均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組在治療后各炎癥因子與治療前比較均降低,治療組在治療后1、3和7 d時(shí)的白細(xì)胞介素6(IL-6)、白細(xì)胞介素8(IL-8)、CRP均低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);治療組在治療后1和3 d時(shí)的腫瘤壞死因子α(TNF-α)低于對(duì)照組,且差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論連續(xù)性血液凈化治療重癥急性胰腺炎患者,在改善RAAS和炎癥因子激活以及療效方面均優(yōu)于基礎(chǔ)治療。
[Abstract]:Objective to investigate the effects of continuous blood purification on the renin angiotensin aldosterone system (RAAS) and inflammatory factors in patients with severe acute pancreatitis (SAP). Methods 64 patients with severe acute pancreatitis hospitalized in the hospital were randomly divided into the treatment group and the control group. The treatment group received continuous blood purification treatment while receiving basic treatment. The control group received basic treatment. The difference between the two groups of patients' main symptoms, indicators returned to normal time and the effective rate of treatment were compared. The differences of RAAS and inflammatory factors were compared between the two groups of patients before and after treatment and 1, 3 and 7 d after treatment. The results of treatment of abdominal pain, nausea, C reaction protein groups after treatment (CRP), serum amylase (AMS) recovery time were lower than the control group, and the difference was statistically significant (P0.05); the total effective rate of treatment group (31 cases, 91.18%) was higher than the control group (21 cases, 70%), with statistical significance the difference (P0.05). The two groups after treatment in the RAAS index before treatment were decreased in the treatment group after treatment of 1 and 3 D of angiotensin, angiotensin II, renin and aldosterone were lower than the control group, the difference was statistically significant (P0.05); the two group after treatment compared with the treatment of various inflammatory factors the decreased IL-2 in the treatment group after treatment 1, 3 and 7 d in 6 (IL-6), interleukin 8 (IL-8) and CRP were lower than the control group, the difference was statistically significant (P0.05); the treatment group after treatment in the 1 and 3 D of tumor necrosis factor alpha (TNF- alpha) lower than that of the control group, and the difference was statistically significant (P0.05). Conclusion continuous blood purification in patients with severe acute pancreatitis is better than basic treatment in improving the activation and efficacy of RAAS and inflammatory factors.
【作者單位】： 南陽(yáng)醫(yī)學(xué)高等�？茖W(xué)校第一附屬醫(yī)院普通外科;南陽(yáng)醫(yī)學(xué)高等�？茖W(xué)校第一附屬醫(yī)院腫瘤內(nèi)科;
【分類號(hào)】：R459.5
【正文快照】： 重癥急性胰腺炎(severe acute pancreatitis,SAP)是臨床常見的危急重癥,在多種復(fù)雜病因的影響下,患者的胰腺發(fā)生自我消化,引起局部炎癥、感染和壞死,并伴有全身炎癥反應(yīng)、多器官功能損害,常因病情復(fù)雜、進(jìn)展迅速而導(dǎo)致較高的死亡率。在病程進(jìn)展過(guò)程中,細(xì)胞因子、炎癥因子的異

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本文編號(hào)：1344796