本文關(guān)鍵詞：基于大鼠皮層微電刺激反饋的閉環(huán)控制系統(tǒng)實現(xiàn)　出處：《浙江大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

  更多相關(guān)文章： 皮層微電刺激 信息反饋 腦機接口 閉環(huán)控制

【摘要】：腦機接口技術(shù)旨在實現(xiàn)大腦和外界環(huán)境之間地直接信息交互,為殘疾患者重建運動或感覺功能提供一種潛在的解決方案。目前主要的腦機接口技術(shù)是利用大腦的神經(jīng)信號控制外部機械設(shè)備,外界信息多用視覺或聽覺等自然感覺進行反饋。這類反饋方式的缺點在于:(1)患者聽覺或視覺輸入有損傷時(失聰或失明)無法提供必要的信息反饋;(2)某些觸覺信息(如溫度、物體表面粗糙度等)無法用視覺反饋進行替代。因此嘗試在神經(jīng)信號控制外部設(shè)備時,將外界信息以皮層微電刺激形式反饋回大腦,構(gòu)成閉環(huán)控制系統(tǒng),有利于實驗動物對外部設(shè)備進行更精確地控制,實現(xiàn)大腦與外界之間直接進行信息雙向交互。本文以大鼠為研究對象,以皮層微電刺激作為信息反饋方式構(gòu)建閉環(huán)控制系統(tǒng)為研究目標(biāo),提出了大鼠利用神經(jīng)元發(fā)放狀態(tài)控制機械手,并以不同電流強度電刺激反饋外界溫度的實驗方案。實驗探究了大鼠對不同參數(shù)電刺激輸入的區(qū)分能力,實現(xiàn)了大鼠利用腦電控制機械手運動,同時完成了皮層微電刺激在腦機接口中的應(yīng)用研究,驗證了將電刺激作為信息反饋方式的可行性以及電刺激信息反饋的有效性。具體內(nèi)容包括:1)搭建了基于大鼠皮層微電刺激反饋的閉環(huán)控制研究平臺。平臺可實時采集大鼠行為學(xué)信號和神經(jīng)元發(fā)放信息,進行在線分析處理,控制外部設(shè)備運動狀態(tài),同時對實驗結(jié)果進行實時可視化顯示。2)分別進行了基于大鼠的腦→機控制實驗以及機→腦的皮層微電刺激區(qū)分實驗,為后期進行皮層微電刺激在腦機接口的應(yīng)用研究奠定基礎(chǔ)。首先進行了電刺激區(qū)分訓(xùn)練,從行為學(xué)和電生理兩個角度探究了大鼠對不同電流強度電刺激的區(qū)分能力,驗證了電刺激作為信息輸入方式的可行性。其次進行了大鼠利用神經(jīng)元發(fā)放狀態(tài)控制機械手的實驗任務(wù),分析了大鼠對運動皮層神經(jīng)元發(fā)放率的調(diào)節(jié)能力。3)進行了皮層微電刺激反饋在腦機接口中的應(yīng)用研究。在大鼠利用腦電控制機械手的同時將外界不同溫度以皮層微電刺激形式反饋給大鼠。通過對大鼠行為學(xué)結(jié)果地分析,探究閉環(huán)控制系統(tǒng)的可行性以及電刺激在其中的信息反饋作用。本文的特點在于將不同電流強度的皮層微電刺激與外界溫度建立對應(yīng)關(guān)系,實現(xiàn)了基于大鼠的閉環(huán)控制系統(tǒng),幫助實驗對象與外界環(huán)境進行更好地信息交互,同時也為殘障患者的運動和感覺功能重建提出了一種新的思路,具有重要的臨床研究意義。
[Abstract]:Brain computer interface technology to achieve between brain and external environment to direct information, provide a potential solution for the reconstruction of disability in patients with motor or sensory function. The interface technology of brain computer is the main use of neural signals to control external devices of the brain, outside information by vision or hearing natural sensory feedback. Feedback the disadvantage of this type is: (1) patients with auditory or visual input damage (deaf or blind) can not provide the necessary information feedback; (2) some tactile information (such as temperature, surface roughness etc.) cannot use visual feedback instead. So try in neural signals to control external devices, will the external information in the cortex electrical stimulation form feedback to the brain, a closed-loop control system for experimental animal, more precise control of external equipment, between the brain and the outside world directly Information interactive. In this paper, the rats as the research object, the cortical electrical stimulation as a way to build information feedback loop control system as the research object, put forward using rat neuron state control manipulator, and different current intensity stimulation experiment outside temperature feedback. Experimental exploration of the rats to distinguish the ability of different electric stimulation parameters input, the EEG of rats using motion control of manipulator, and completed the application in brain-computer interface micro electric cortical stimulation, electrical stimulation will be verified as the feedback method of the feasibility and effectiveness of the stimulation of information feedback. The specific contents include: 1) build the closed loop of rat cortical electrical stimulation feedback control research platform based on real time acquisition behavior of rats and neuron signal information, on-line analysis processing, control department Preparation of the state of motion, and the experimental results in real time visualization of.2) were carried out based on the brain, experimental machine, machine control and cortical brain stimulation between experimental rats, micro electrical stimulation is applied in the study of brain computer interfaces and lay the foundation for the later cortex. Electrical stimulation training was first distinguished from. Two aspects of behavioral and electrophysiological studies on rats ability to distinguish different current intensity of electrical stimulation, electrical stimulation is verified the feasibility of the information input method. Secondly, the rats with neuronal firing experiment task state control of the manipulator, analyzes the rat firing rate adjustment ability of.3 on motor cortex neurons) the cortex electrical stimulation feedback application in brain computer interface. In rats by simultaneous EEG to control the manipulator to the outside world at different temperatures in the cortex electrical stimulation to form feedback Rat. The rat behavioral results analysis, explore the feasibility and the closed-loop control system of electrical stimulation feedback in the information. This article is characterized by the current strength of the different cortical electrical stimulation and the outside temperature to establish the correspondence between the closed loop control system based on experimental rats, help object with the outside world the environment for better information interaction, but also put forward a new idea for the motor and sensory function reconstruction of disabled patients, has important clinical significance.

【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：TP273;R49

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