【摘要】：超高場(chǎng)磁共振成像系統(tǒng)是基于大型超導(dǎo)技術(shù)產(chǎn)生的超強(qiáng)穩(wěn)態(tài)磁場(chǎng)環(huán)境下的磁共振系統(tǒng)。相比傳統(tǒng)的磁共振成像系統(tǒng),主要特點(diǎn)是成像分辨率高。因此可以借助其更為精細(xì)的磁共振成像結(jié)果進(jìn)行醫(yī)學(xué)、物理、化學(xué)以及相關(guān)交叉學(xué)科的研究。由于超高場(chǎng)磁共振成像系統(tǒng)的主磁體磁場(chǎng)強(qiáng)度高,所以,相對(duì)于低場(chǎng)系統(tǒng),其射頻功放、梯度功放以及射頻線圈技術(shù)等都需要不同程度的改進(jìn)。超高場(chǎng)磁共振成像系統(tǒng)的發(fā)展實(shí)際上是在主磁體強(qiáng)度不斷增加的引領(lǐng)下,相關(guān)技術(shù)的同步發(fā)展。本文的主要工作都是基于中科院強(qiáng)磁場(chǎng)中心的9.4 T超高場(chǎng)磁共振成像系統(tǒng)下完成的,主要包括四部分:一,針對(duì)超高場(chǎng)下磁共振成像的小型哺乳動(dòng)物成像應(yīng)用、微型離體組織成像應(yīng)用和高分辨率成像應(yīng)用,設(shè)計(jì)出相應(yīng)的射頻線圈;二,針對(duì)射頻線圈優(yōu)化方法的研究,基于傳統(tǒng)鳥(niǎo)籠線圈技術(shù)基礎(chǔ),在超高場(chǎng)條件下,通過(guò)改變導(dǎo)體表面形狀來(lái)探索有效的射頻線圈優(yōu)化方案;三,針對(duì)磁共振成像系統(tǒng)下掃描過(guò)程中的樣品微量注射的精確控制,基于虛擬儀器LabVIEW設(shè)計(jì)研發(fā)了一套實(shí)時(shí)視頻監(jiān)控系統(tǒng),四,針對(duì)如何使磁共振成像系統(tǒng)掃描操作和激光器運(yùn)行協(xié)調(diào)一致,設(shè)計(jì)了一套基于LabVIEW的多模塊開(kāi)關(guān)控制系統(tǒng)。對(duì)于射頻線圈改進(jìn)技術(shù)的研究,主要采用了基于有限元的方法對(duì)射頻線圈電磁場(chǎng)分布進(jìn)行分析和仿真,采用耐高功率、低功耗的電容元件,不同形狀的導(dǎo)體材料,3D打印材料以及非磁性支撐材料進(jìn)行不同參數(shù)的新型射頻線圈的制作,利用活體哺乳動(dòng)物、離體生物組織以及生理鹽水等多種被測(cè)樣品在網(wǎng)絡(luò)分析儀和9.4T磁共振平臺(tái)下進(jìn)行了參數(shù)測(cè)試和成像實(shí)驗(yàn)。針對(duì)實(shí)時(shí)視頻監(jiān)控系統(tǒng)和開(kāi)關(guān)系統(tǒng)的設(shè)計(jì),主要基于LabVIEW軟件平臺(tái)進(jìn)行編程,利用NI數(shù)據(jù)采集卡作為控制平臺(tái)和設(shè)備之間的交互,采用計(jì)算機(jī)和網(wǎng)絡(luò)分析儀在9.4T磁共振平臺(tái)下進(jìn)行試驗(yàn)驗(yàn)證。本文的主要研究充分結(jié)合實(shí)際應(yīng)用,在超高場(chǎng)平臺(tái)下開(kāi)展,通過(guò)對(duì)研究方法、研究過(guò)程和實(shí)驗(yàn)結(jié)果進(jìn)行了深入論述,為以后的超高場(chǎng)磁共振成像射頻線圈技術(shù)和相關(guān)附加應(yīng)用的進(jìn)一步發(fā)展提供有效參考。
[Abstract]:Ultra-high field magnetic resonance imaging system is a magnetic resonance system based on super steady magnetic field produced by large superconducting technology. Compared with the traditional magnetic resonance imaging system, the main characteristic is the high imaging resolution. Therefore, medical, physical, chemical and related interdisciplinary research can be carried out with the help of its more detailed magnetic resonance imaging results. Because of the high magnetic field intensity of the main magnet in the ultra-high field magnetic resonance imaging system, the RF power amplifier, gradient power amplifier and RF coil technology need to be improved in varying degrees compared with the low field system. The development of ultra-high field magnetic resonance imaging system is actually the synchronous development of related technologies under the guidance of the increasing strength of the main magnet. The main work of this paper is based on the 9.4 T ultra-high field magnetic resonance imaging system of the strong magnetic field center of the Chinese Academy of Sciences, which mainly includes four parts: first, the corresponding RF coils are designed for the small mammal imaging applications, the micro in vitro tissue imaging applications and the high resolution imaging applications of magnetic resonance imaging in ultra high field; Second, according to the research of RF coil optimization method, based on the traditional birdcage coil technology, the effective RF coil optimization scheme is explored by changing the conductor surface shape under the condition of ultra-high field. Third, aiming at the accurate control of sample microinjection in the scanning process of magnetic resonance imaging system, a set of real-time video monitoring system is designed and developed based on virtual instrument LabVIEW. Fourth, a multi-module switching control system based on LabVIEW is designed to make the scanning operation of magnetic resonance imaging system consistent with the operation of laser. For the research of RF coil improvement technology, the electromagnetic field distribution of RF coil is analyzed and simulated based on finite element method. The new RF coil with different parameters is fabricated by high power resistance, low power consumption capacitance element, conductor material with different shape, 3D printing material and non-magnetic supporting material, and the living mammals are used to fabricate the new RF coil with different parameters. The parameters and imaging experiments of in vitro biological tissues and saline were carried out under the network analyzer and 9.4T magnetic resonance platform. Aiming at the design of real-time video surveillance system and switching system, it is mainly programmed based on LabVIEW software platform. NI data acquisition card is used as the interaction between the control platform and the device, and the computer and network analyzer are used to verify the experiment under 9.4T magnetic resonance platform. In this paper, the main research is fully combined with practical application, carried out under the ultra-high field platform, through the research methods, research process and experimental results are discussed in depth, which provides an effective reference for the further development of ultra-high field magnetic resonance imaging RF coil technology and related additional applications in the future.
【學(xué)位授予單位】：中國(guó)科學(xué)技術(shù)大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：O482.531;TN948.6

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