本文選題：人工耳蝸 + 脈沖激光　； 參考：《清華大學(xué)學(xué)報(bào)(自然科學(xué)版)》2017年10期

【摘要】：近年來(lái)以脈沖激光誘發(fā)聽(tīng)神經(jīng)響應(yīng)的研究逐步深入,然而目前國(guó)內(nèi)外對(duì)于光刺激聽(tīng)神經(jīng)的機(jī)理研究尚未有定論。該文利用仿真軟件COMSOL Multiphysics研究了三維模型脈沖激光刺激耳蝸產(chǎn)生的光熱現(xiàn)象和光聲現(xiàn)象,同時(shí)結(jié)合活體豚鼠實(shí)驗(yàn)結(jié)果分析了光刺激聽(tīng)神經(jīng)的機(jī)理。結(jié)果顯示:仿真中光刺激聽(tīng)神經(jīng)產(chǎn)生了溫升,也引發(fā)了光聲效應(yīng);活體動(dòng)物實(shí)驗(yàn)中光刺激在藥物急性致聾的豚鼠中誘發(fā)出復(fù)合聽(tīng)神經(jīng)動(dòng)作電位。結(jié)果分析表明:光刺激耳蝸產(chǎn)生的響應(yīng)更可能是光聲效應(yīng)和光熱效應(yīng)共同作用的結(jié)果。
[Abstract]:In recent years, the response of auditory nerve induced by pulsed laser has been studied step by step. However, the mechanism of optical stimulation of auditory nerve has not been concluded at home and abroad.In this paper, the photothermal and photoacoustic phenomena produced by three-dimensional pulsed laser stimulation of cochlea were studied by COMSOL Multiphysics, and the mechanism of photostimulation of auditory nerve was analyzed in combination with the experimental results of guinea pigs in vivo.The results showed that photostimulation of auditory nerve produced temperature rise and photoacoustic effect, and in vivo animal experiment, photostimulation induced compound auditory nerve action potential in guinea pigs with acute deafness induced by drugs.The results showed that the response of the cochlea stimulated by light was more likely to be the result of the combination of photoacoustic effect and photothermal effect.
【作者單位】： 清華大學(xué)深圳研究生院生物醫(yī)學(xué)工程研究中心;清華大學(xué)生物醫(yī)學(xué)工程系;深圳信息職業(yè)技術(shù)學(xué)院電子與通信學(xué)院;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(31271056,81401539)
【分類(lèi)號(hào)】：R764;TP391.9

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