本文關(guān)鍵詞： 非神經(jīng)精神性紅斑狼瘡 彌散張量成像 基于纖維束示蹤的空間統(tǒng)計(jì) 概率性纖維追蹤 結(jié)構(gòu)網(wǎng)絡(luò) 圖論分析　出處：《南方醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：神經(jīng)精神性狼瘡(neuropsychiatric systemic lupus erythematosus,NPSLE)是當(dāng)系統(tǒng)性紅斑狼瘡累及中樞及周圍神經(jīng)系統(tǒng)時(shí)產(chǎn)生的并發(fā)癥。在NPSLE發(fā)病早期,沒有出現(xiàn)神經(jīng)精神性臨床癥狀時(shí)被稱為非神經(jīng)精神性狼瘡(non-NPSLE)。近年研究發(fā)現(xiàn)non-NPSLE患者的大腦已經(jīng)出現(xiàn)了腦結(jié)構(gòu)和腦功能的異常,其中白質(zhì)受損被認(rèn)為是相對(duì)重要的因素。彌散張量成像(diffusion tensor imaging,DTI)是能夠無(wú)創(chuàng)性地獲取白質(zhì)中神經(jīng)纖維走行及髓鞘信息的影像學(xué)技術(shù)。本文利用兩種基于DTI的分析方法,研究non-NPSLE患者與正常對(duì)照組(healthy control,HC)之間白質(zhì)結(jié)構(gòu)的差異。第一部分研究是利用基于DTI的纖維束示蹤空間統(tǒng)計(jì)(tract-based spatial statistics,TBSS)方法分析腦白質(zhì)微結(jié)構(gòu)。實(shí)驗(yàn)選用經(jīng)過納入及排除標(biāo)準(zhǔn)篩選后的29例non-NPSLE女性患者與29例女性志愿者作為兩組被試采集圖像數(shù)據(jù)。通過FSL軟件的標(biāo)準(zhǔn)處理步驟與流程,計(jì)算得到兩組被試自身的部分各向異性(fractional anisotropy,FA)骨架圖,再對(duì)FA骨架圖進(jìn)行組間全腦顯著性差異的統(tǒng)計(jì)學(xué)分析。實(shí)驗(yàn)結(jié)果顯示:與HC組相比,non-NPSLE組的FA值主要在胼壿體體部、胼胝體壓部、胼胝體膝部、雙側(cè)前放射冠、雙側(cè)上縱束、雙側(cè)上放射冠、雙側(cè)外囊、右側(cè)丘腦后輻射等位置顯著降低。結(jié)果提示患者組的大腦白質(zhì)完整性降低,白質(zhì)髓鞘的微小結(jié)構(gòu)以及軸突可能存在異常。第二部分的研究是利用基于DTI的腦網(wǎng)絡(luò)分析方法研究白質(zhì)結(jié)構(gòu)網(wǎng)絡(luò),使用概率性纖維束追蹤技術(shù)以及圖論分析探究患者組全腦水平上的白質(zhì)連接以及網(wǎng)絡(luò)拓?fù)鋵傩缘漠惓�。腦網(wǎng)絡(luò)分析方法的基本流程為:數(shù)據(jù)預(yù)處理;基于標(biāo)準(zhǔn)AAL模板劃分大腦為90個(gè)功能腦區(qū);使用概率性纖維束追蹤重建白質(zhì)纖維,構(gòu)建結(jié)構(gòu)網(wǎng)絡(luò)矩陣;計(jì)算網(wǎng)絡(luò)的各項(xiàng)拓?fù)淞慷?統(tǒng)計(jì)學(xué)分析。實(shí)驗(yàn)結(jié)果為:(1)non-NPSLE組的全局網(wǎng)絡(luò)效率與局部網(wǎng)絡(luò)效率顯著降低,特征路徑長(zhǎng)度顯著增加,反映網(wǎng)絡(luò)的信息整合及交換能力受損;(2)當(dāng)節(jié)點(diǎn)的度為度量參數(shù)時(shí),non-NPSLE組的中樞節(jié)點(diǎn)分布改變;(3)non-NPSLE組的節(jié)點(diǎn)效率在右島蓋部額下回、右三角部額下回以及左內(nèi)側(cè)和旁扣帶腦回處顯著降低,節(jié)點(diǎn)的度在右島蓋部額下回、左右內(nèi)側(cè)和旁扣帶回、右梭狀回、右楔前葉處顯著降低,節(jié)點(diǎn)的度在左眶部額上回、左枕下回處顯著增加,這些腦區(qū)涉及語(yǔ)言功能、視覺功能以及默認(rèn)網(wǎng)絡(luò)等功能;(4)non-NPSLE組的網(wǎng)絡(luò)全局效率、局部效率以及部分異常腦區(qū)的節(jié)點(diǎn)效率和度與疾病活動(dòng)指數(shù)具有顯著負(fù)相關(guān);(5)non-NPSLE組出現(xiàn)一個(gè)連接顯著降低的子網(wǎng)絡(luò)以及兩個(gè)連接顯著增強(qiáng)的子網(wǎng)絡(luò)。本文中兩項(xiàng)基于DTI的研究發(fā)現(xiàn):non-NPSLE患者的白質(zhì)纖維束完整性在部分區(qū)域出現(xiàn)顯著性降低;白質(zhì)連接網(wǎng)絡(luò)的拓?fù)浣Y(jié)構(gòu)與HC有顯著差異。研究結(jié)果為進(jìn)一步研究NPSLE早期的發(fā)病機(jī)制提供影像學(xué)依據(jù)。
[Abstract]:Neuropsychiatric systemic lupus erythematosus. NPSLE is a complication that occurs when systemic lupus erythematosus is involved in the central and peripheral nervous systems. Patients without neuropsychiatric symptoms are referred to as non-neuropsychiatric lupus (non-NPSLEs). In recent years, it has been found that the brain of patients with non-NPSLE has abnormal brain structure and function. The white matter damage is considered to be a relatively important factor. Diffusion Zhang Liang imaging diffusion tensor imaging. DTI) is an imaging technique that can obtain the information of nerve fiber walking and myelin sheath in white matter in a noninvasive way. Two analysis methods based on DTI are used in this paper. To study healthy control in non-NPSLE patients and normal controls. The first part of the study was to use tract-based spatial statistics based on tracer space of fiber bundle based on DTI. TBSS). Methods the microstructures of white matter were analyzed. Twenty-nine female non-NPSLE patients and 29 female volunteers were selected as two groups to collect image data by FS. The standard processing steps and processes of L software. Two groups of partial anisotropic fractional anisotropic FAA skeleton diagrams were obtained. Compared with HC group, the FA value of non-NPSLE group was mainly located in callosal body and corpus callosum. The genu of corpus callosum, bilateral anterior radiative corona, bilateral superior longitudinal bundle, bilateral superior coronal, bilateral external capsule and right posterior thalamic radiation were significantly decreased. The results indicated that the integrity of the white matter of the cerebrum was decreased in the patients group. The microstructures and axons of the white matter myelin sheath may be abnormal. The second part is to study the white matter structure network using the brain network analysis method based on DTI. Probabilistic fiber bundle tracing technique and graph theory analysis were used to explore the white matter connection and the abnormal topological properties of the network at the whole brain level in the patient group. The basic process of the brain network analysis method was as follows: data preprocessing; The brain was divided into 90 functional brain regions based on standard AAL template. Using probabilistic fiber bundles to track and reconstruct white matter fibers, structure network matrix was constructed. Calculate the topological metrics of the network; The experimental results showed that the global network efficiency and local network efficiency of the non-NPSLE group were significantly decreased, and the length of the characteristic path was significantly increased. The information integration and exchange ability of the network is damaged; (2) the distribution of central nodes in non-NPSLE patients was changed when the degree of nodes was a metric parameter. In the non-NPSLE group, the nodal efficiency was significantly decreased in the inferior frontal gyrus of the right tegmental part, the inferior frontal gyrus of the right triangular part and the left medial and accessory cingulate gyrus, and the degree of the node was in the inferior frontal gyrus of the right tegmental part. The left and right medial and accessory cingulate gyrus, right fusiform gyrus, right anterior cuneate lobe decreased significantly, the degree of nodes in left orbital superior frontal gyrus and left inferior occipital gyrus increased significantly. Visual function and default network function; In non-NPSLE group, the global network efficiency, local efficiency and node efficiency and degree of some abnormal brain regions were negatively correlated with disease activity index. 5). In the non-NPSLE group, there is a subnetwork with significantly reduced connections and two significantly enhanced subnetworks. Two DTI based studies in this paper found that:. The integrity of white matter fiber bundle in non-NPSLE patients decreased significantly in some areas. The topological structure of the white matter junction network is significantly different from that of HC. The results provide imaging evidence for further study of the pathogenesis of NPSLE in the early stage.
【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：TP391.41;R593.241;R747.9

【參考文獻(xiàn)】

相關(guān)期刊論文 前4條

1 嚴(yán)雪嬌;李瑋;王亞蓉;李強(qiáng);李永斌;朱佳;陳佳杰;王瑋;;短期戒斷的海洛因成癮者大腦白質(zhì)完整性的DTI研究[J];磁共振成像;2015年02期

2 鐘智輝;余太慧;王雷;陽(yáng)維;馮美燕;盧振泰;陳武凡;馮衍秋;;一種用于膝關(guān)節(jié)軟骨T2值測(cè)量的自動(dòng)分區(qū)方法[J];南方醫(yī)科大學(xué)學(xué)報(bào);2013年06期

3 梁夏;王金輝;賀永;;人腦連接組研究:腦結(jié)構(gòu)網(wǎng)絡(luò)和腦功能網(wǎng)絡(luò)[J];科學(xué)通報(bào);2010年16期

4 陳武凡;;并行磁共振成像的回顧、現(xiàn)狀與發(fā)展前景[J];中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào);2005年06期

相關(guān)博士學(xué)位論文 前1條

1 譚相良;非神經(jīng)精神性狼瘡患者腦靜息下多模態(tài)磁共振成像研究[D];南方醫(yī)科大學(xué);2015年

，

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