本文關(guān)鍵詞： 內(nèi)生真菌 雜色曲霉 喹諾唑啉酮 鹵蟲致死活性 抗菌活性　出處：《中國抗生素雜志》2017年04期 　論文類型：期刊論文

【摘要】：從分離自紅樹林植物欖李新鮮葉片中的內(nèi)生真菌雜色曲霉Aspergillus versicolor MA-229的發(fā)酵產(chǎn)物中分離得到新化合物1(22-epi-aflaquinolone B)和4個(gè)4-苯基-3,4-二氫喹啉酮類化合物(2~5)以及4個(gè)喹諾唑啉酮類化合物(6~9)。通過核磁共振和質(zhì)譜等技術(shù)對化合物的結(jié)構(gòu)進(jìn)行了鑒定,并且通過X-射線單晶衍射實(shí)驗(yàn)確定了化合物1的絕對構(gòu)型。這些化合物均表現(xiàn)出不同程度的鹵蟲致死活性和抗菌活性,其中新化合物1有明顯的鹵蟲致死活性(LD50值為1.73μmol/L),與陽性對照活性相當(dāng)。化合物1對農(nóng)業(yè)病害菌小麥全蝕病菌(Gaeumannomyces graminis)也具有一定的抑制活性(MIC值為32μg/mL),化合物6對農(nóng)業(yè)病害菌小麥赤霉病菌(Fusarium graminearum)有較好的抑制活性(MIC值為16μg/mL)。
[Abstract]:From the fermentation products of endophytic fungi, Aspergillus versicolor MA-229, isolated from fresh leaves of mangrove plant Elemulus elematis, a new compound, 1P22-epi-aflaquinolone B) and 4 4-phenyl-3-4-dihydroquinolone compounds-2-5) and 4 quinoxolinones were isolated from the fermentation products of Aspergillus specialis, Aspergillus versicolor MA-229, from the fresh leaves of the mangrove plant. The structures of the compounds were identified by NMR and mass spectrometry. The absolute configuration of compound 1 was determined by X-ray single crystal diffraction. The LD50 value of the new compound 1 was 1.73 渭 mol / L ~ (-1), which was similar to that of the positive control. Compound 1 also had a certain inhibitory activity to the agricultural disease bacterium, Gaeumannomyces graminis, and the MIC value of compound 6 to agriculture was 32 渭 g / m ~ (-1). Fusarium graminearum (Fusarium graminearum) had a good inhibitory activity and the MIC value was 16 渭 g / mL 路L ~ (-1).
【作者單位】： 中國科學(xué)院海洋研究所實(shí)驗(yàn)海洋生物學(xué)重點(diǎn)實(shí)驗(yàn)室;青島海洋科學(xué)與技術(shù)國家實(shí)驗(yàn)室海洋生物學(xué)與生物技術(shù)功能實(shí)驗(yàn)室;
【基金】：國家自然科學(xué)基金(No.31270403)
【分類號】：S476.1
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本文編號：1542654