背景載脂蛋白E基因(APOE)多態(tài)性與血脂譜和心血管疾病有關(guān);然而,這些關(guān)系因種族而異。載脂蛋白E有E2、E3、E4這3個(gè)亞型,分別由ε2,ε3和ε4這3個(gè)等位基因編碼。E3是漢族人群中最常見的亞型,E2是最少見的亞型。除載脂蛋白E外,高敏感性C-反應(yīng)蛋白(hs-CRP)和N-端前B型利鈉肽(NT-proBNP)近來也作為心血管疾病的新型危險(xiǎn)因素。然而載脂蛋白E的基因多態(tài)性與這些心血管疾病危險(xiǎn)因素之間是否具有關(guān)聯(lián)性,仍尚不清楚。目的本研究首次對(duì)漢族人群進(jìn)行了研究,評(píng)估了載脂蛋白E基因多態(tài)性的分布及其與急性冠狀動(dòng)脈綜合征(ACS)、血脂譜及其他心臟代謝風(fēng)險(xiǎn)因素的關(guān)系。同時(shí),我們研究hs-CRP和NT-proBNP與APOE基因型的關(guān)系方法本前瞻性研究納入800名漢族受試者,其中ACS212例,非ACS者588例。對(duì)rs7412和rs429358基因型進(jìn)行了TaqMan分析,這兩個(gè)變異型決定APOE等位基因的ε2,ε3和ε4等位基因。結(jié)果ε2、ε3和ε4的頻數(shù)分別占總體樣本的3.8%,76.9%和19.3%。ACS與載脂蛋白E4亞型有關(guān)。非急性冠脈綜合征組載脂蛋白ε4攜帶者總膽固醇水平高于...

【文章頁(yè)數(shù)】：68 頁(yè)

【學(xué)位級(jí)別】：碩士

【文章目錄】：
Abbreviation
摘要
Abstract
1.Introduction
    1.1 Can APOE genotype be used as a screening test for cardiovascular diseases?
    1.2 Association between APOE gene variations and plasma levels of high sensitive C-reactive protein(hs-CRP)
    1.3 The association of CRP and APOE polymorphism NT-pro BNP
2.Methodology
    2.1 Study Site
    2.2 Study design
    2.3 Study population
    2.4 Inclusion criteria
    2.5 Diagnostic criteria
    2.6 Exclusion Criteria
    2.7 Data collection
    2.8 Biochemical analyses
    2.9 Determination of APOE isoforms
    2.10 Definition of clinical components
    2.11 Statistical examinations
3.Result
    3.1 Characteristics of ACS and non-ACS patients
    3.2 Lipid profile and APOE polymorphism in non-ACS and ACS patients
    3.3 Association between other cardio-metabolic risk factors and APOE allele
4.Discussion
    4.1 Allelic distribution of APOE in Han Chinese
    4.2 Association of APOE polymorphism with the lipid profile
        4.2.1 Non ACS group
        4.2.2 ACS group
    4.3 Association of APOE polymorphism with ACS
    4.4 Association of APOE polymorphism with other cardio-metabolic risk Factors
5.Conclusions
6.References
7.Review of literature
    7.1 APOE gene
    7.2 Gene variants of APOE
    7.3 APOEisoform and its influence on lipid metabolism
    7.4 Structure of APOEIsoform
    7.5 Dispersal of APOE on lipoproteins
    7.6 Effect of APOE isoforms on lipoprotein
    7.7 APOE polymorphism and its impact on blood lipid level in Han Chinese
    7.8 The association of Apo E gene polymorphism to Acute Coronary Syndrome in Han Chinese
    7.9 Relation between APOE gene polymorphism and major adverse cardiovascular events inpatients with ACS
        Mechanism of APOE allele in increasing the risk of CAD
    7.10 Association between APOE gene variations and plasma levels of Hs-CRP
    7.11 References for Review of literature
Resume
ACKNOWLEDGEMENTS



本文編號(hào)：3834320