發(fā)布時間：2018-04-25 23:34

  本文選題：純鎂 + 超聲微弧氧化��； 參考：《佳木斯大學(xué)》2015年碩士論文

【摘要】：純鎂由于其密度、楊氏模量與人骨接近,又具有可降解性、適當(dāng)?shù)膹?qiáng)度和良好的生物活性,使之成為最具有發(fā)展?jié)摿Φ纳镝t(yī)用材料,也成為了國內(nèi)外可降解骨內(nèi)固定修復(fù)材料的研究熱點(diǎn)。但純鎂在體內(nèi)存在著降解速度過快的弊端,和骨組織的生長不能很好地達(dá)到匹配,因而限制了純鎂在臨床領(lǐng)域的應(yīng)用。對純鎂進(jìn)行表面改性是解決此問題最行之有效的方法之一。在純鎂表面制備超聲微弧氧化(簡稱UMAO)涂層,可改善其耐蝕性,但是純鎂UMAO涂層存在的微孔仍可使腐蝕介質(zhì)到達(dá)鎂基體而將基體腐蝕。因此,針對這一問題,本文采用超聲微弧氧化技術(shù)在純鎂表面制備出UMAO涂層,再進(jìn)行植酸、植酸-絲素蛋白(簡稱SF)、NaOH-硅烷偶聯(lián)劑(簡稱SCA)-SF不同的后處理,并對相關(guān)后處理工藝參數(shù)進(jìn)行了優(yōu)化,實(shí)現(xiàn)調(diào)控了涂層的可降解性及生物活性。本實(shí)驗(yàn)對涂層的微觀形貌、元素組成、官能團(tuán)構(gòu)成、結(jié)合強(qiáng)度、耐磨性、潤濕性、耐蝕性及體外Hank's浸泡生物活性進(jìn)行了研究,具體結(jié)論如下:采用不同濃度的植酸對純鎂UMAO涂層進(jìn)行后處理,可發(fā)現(xiàn):隨著植酸濃度的升高,UMAO涂層微孔數(shù)量減少,無碎裂現(xiàn)象,涂層更加均勻致密,覆蓋度提高,表面覆蓋羥基和磷酸基,涂層的結(jié)合強(qiáng)度、耐磨性、耐蝕性等均有所改善,經(jīng)過Hank's溶液浸泡后,涂層發(fā)生了降解,并與Ca、P等元素結(jié)合,生成新的物質(zhì)-類骨磷灰石。其中植酸的處理濃度為7.5g/L時為最佳。用7.5g/L植酸處理的UMAO涂層經(jīng)過SF不同時間的處理后,可發(fā)現(xiàn):隨著SF溶液處理時間的延長,涂層的孔洞數(shù)量逐漸減少,涂層更加致密,涂層的結(jié)合強(qiáng)度、耐磨性、潤濕性、耐蝕性等均有提高,經(jīng)過Hank's溶液浸泡3天時即有新的物質(zhì)-類骨磷灰石生成。其中,SF溶液的處理時間為1.5h時為最佳。對UMAO涂層進(jìn)行NaOHSCA-SF不同的時間處理后,可發(fā)現(xiàn):隨著SF處理時間的延長,涂層的孔隙被填充的越來越均勻致密,平整度也越來越好,且涂層的結(jié)合強(qiáng)度、耐磨性、潤濕性、耐蝕性等均有所提高。純鎂UMAO涂層經(jīng)植酸、植酸-SF、SCA-SF處理發(fā)生化學(xué)反應(yīng)生成的新物質(zhì)或發(fā)生各物質(zhì)之間的相互作用,有效地填充了UMAO涂層的孔隙,阻擋了腐蝕介質(zhì)到達(dá)基體,并成膜,達(dá)到調(diào)控涂層可降解性的目的,同時,由于絲素蛋白具有良好的生物相容性,也提高了復(fù)合涂層的生物活性。綜合比較,UMAONaOH-SCA-SF/1.5h處理的復(fù)合涂層具有最優(yōu)異的性能。
[Abstract]:Pure magnesium, due to its density, Young's modulus and human bone, has biodegradability, appropriate strength and good biological activity, making it the most promising biomedical material. It has also become the research hotspot of degradable bone internal fixation materials at home and abroad. However, the degradation rate of pure magnesium in vivo is too fast, and the growth of bone tissue can not match well, which limits the application of pure magnesium in clinical field. Surface modification of pure magnesium is one of the most effective methods to solve this problem. Ultrasonic micro-arc oxidation (UMAO) coating on pure magnesium surface can improve its corrosion resistance, but the micropore of pure magnesium UMAO coating can still make the corrosion medium reach magnesium substrate and corrode the substrate. Therefore, in order to solve this problem, the UMAO coating was prepared on the surface of pure magnesium by ultrasonic micro-arc oxidation, and then the phytic acid, phytic acid-silk fibroin (SCA)-SF) coupling agent (SCA)-SF) was used for different post-treatment. The process parameters were optimized to control the biodegradability and bioactivity of the coating. The microstructure, composition of elements, composition of functional groups, binding strength, wear resistance, wettability, corrosion resistance and bioactivity of Hank's immersion in vitro were studied. The specific conclusions are as follows: after treatment of pure magnesium UMAO coating with different concentrations of phytic acid, it can be found that with the increase of phytic acid concentration, the number of micropores in UMAO coating decreases, there is no fragmentation, the coating is more uniform and compact, and the coverage is improved. The bonding strength, wear resistance and corrosion resistance of the coating were improved. After soaking in Hank's solution, the coating was degraded and combined with CaOP-like elements to form a new substance, bone-like apatite. The best treatment concentration of phytic acid was 7.5g/L. After the UMAO coating treated with 7.5g/L phytic acid was treated with SF for different time, it was found that with the prolongation of the treatment time of SF solution, the number of holes in the coating gradually decreased, the coating became denser, the bonding strength, wear resistance and wettability of the coating were increased. The corrosion resistance was improved and a new substance, bone-like apatite, was formed after soaking in Hank's solution for 3 days. The best treatment time is 1.5 h. After NaOHSCA-SF treatment of UMAO coating at different time, it can be found that with the prolongation of SF treatment time, the pores of the coating are more and more uniform and compact, the flatness is better and better, and the bonding strength, wear resistance and wettability of the coating are also improved. Corrosion resistance has been improved. Pure magnesium UMAO coating was treated with phytic acid, phytic acid -SFNSCA-SF to produce new substances or interaction between them, which effectively filled the pores of UMAO coating, prevented corrosion medium from reaching the substrate, and formed film. The biodegradability of the coating was controlled and the bioactivity of the composite coating was improved because of the good biocompatibility of silk fibroin. The composite coating treated with UMAO NaOH-SCA-SF / 1.5 h has the best performance.
【學(xué)位授予單位】：佳木斯大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2015
【分類號】：TG174.44

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